Quality of Life in Inflammatory Bowel Disease

Love, Jonathan; Irvine, E. Jan; Fedorak, Richard

doi:10.1097/00004836-199201000-00005

Cited by 186 publications

(91 citation statements)

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“…A significant number of patients with IBD consider that their quality of life is adversely affected by their disease (13) . This has been corroborated by studies indicating reduced quality of life compared with an age-and sex-matched population (27) . Health related quality of life studies provide insights into the influence of IBD on patient's lives, and the potential impact on professional and personal productivity.…”

Section: Introductionmentioning

confidence: 57%

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

Magalhães¹,

Castro²,

Carvalho³

et al. 2014

Arq. Gastroenterol.

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-Context -Inflammatory bowel disease causes physical and psychosocial consequences that can affect the health related quality of life. Objectives -To analyze the relationship between clinical and sociodemographic factors and quality of life in inflammatory bowel disease patients. Methods -Ninety two patients with Crohn's disease and 58 with ulcerative colitis, filled in the inflammatory bowel disease questionnaire (IBDQ-32) and a questionnaire to collect sociodemographic and clinical data. The association between categorical variables and IBDQ-32 scores was determined using Student t test. Factors statistically significant in the univariate analysis were included in a multivariate regression model. Results -IBDQ-32 scores were significantly lower in female patients (P<0.001), patients with an individual perception of a lower co-workers support (P<0.001) and career fulfillment (P<0.001), patients requiring psychological support (P = 0.010) and pharmacological treatment for anxiety or depression (P = 0.002). A multivariate regression analysis identified as predictors of impaired HRQOL the female gender (P<0.001) and the perception of a lower co-workers support (P = 0.025) and career fulfillment (P = 0.001). Conclusion -The decrease in HRQQL was significantly related with female gender and personal perception of disease impact in success and social relations. These factors deserve a special attention, so timely measures can be implemented to improve the quality of life of patients. HEADINGS -Inflammatory bowel diseases. Crohn disease. Ulcerative colitis. Quality of life. Questionnaires.

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Section: Introductionmentioning

confidence: 57%

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

Magalhães¹,

Castro²,

Carvalho³

et al. 2014

Arq. Gastroenterol.

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“…Disease-specific quality of life was assessed with the German version of the Inflammatory Bowel Disease Questionnaire (IBDQ) [48,49,50,51]. Its 32 items are grouped into four dimensions, namely Bowel Function, Emotional Status, Systemic Symptoms, Social Function.…”

Section: Methodsmentioning

confidence: 99%

Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis

Elsenbruch¹,

Langhorst²,

Popkirowa

et al. 2005

Psychother Psychosom

157

114

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Background: The aim of this study was to investigate the effects of mind-body therapy on neuroendocrine and cellular immune measures, health-related quality of life and disease activity in patients with ulcerative colitis (UC) in remission. Methods: Thirty UC patients in remission or with low disease activity were randomly assigned to an intervention group (n = 15) or a usual-care waiting control group (n = 15). Intervention consisted of a structured 60-hour training program over 10 weeks which included stress management training, moderate exercise, Mediterranean diet, behavioral techniques and self-care strategies. Quality of life, perceived stress and disease activity were assessed with standardized questionnaires (IBDQ, SF-36, PSS, CAI). In addition, the distribution of circulating lymphocytes and lymphocyte subsets as well as the β-adrenergic modulation of TNF-α production in vitro were analyzed. Urine catecholamines and plasma cortisol, prolactin and growth hormone were measured pre- and postinterventionally, and were compared with a healthy control group (n = 10). Results: In response to therapy, patients in the intervention group showed significantly greater improvement in the SF-36 scale Mental Health and the Psychological Health Sum score compared with changes observed in the usual-care waiting control group. Patients in the intervention group showed significantly greater improvement on the IBDQ scale Bowel Symptoms compared with the control group. However, no significant group differences in circulating lymphocyte subsets or endocrine parameters were observed in response to therapy. In addition, no significant effects of intervention on either the basal levels of TNF-α or the suppressive action of the β-adrenergic agonist isoproterenol on TNF-α production were observed. Conclusion: Mind-body therapy may improve quality of life in patients with UC in remission, while no effects of therapy on clinical or physiological parameters were found, which may at least in part be related to selective patient recruitment.

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“…[21][22][23] Several patient-reported outcome measures have been developed for IBD with the goal of quantifying the holistic effects of these conditions, but they lack coverage with respect to adherence attitudes. 24,25 The objective of this study was to understand patients' attitudes toward adherence in order to help inform a conceptual model of patients' barriers to adherence. tion was 7 years, and 13 out of 27 were also on maintenance immunomodulators or biologics because of prior moderate to severe disease.…”

Section: What This Study Addsmentioning

confidence: 99%

Barriers to Mesalamine Adherence in Patients with Inflammatory Bowel Disease: A Qualitative Analysis

Devlen¹,

Beusterien²,

Yen³

et al. 2014

JMCP

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Quality of Life in Inflammatory Bowel Disease

Cited by 186 publications

References 0 publications

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis

Barriers to Mesalamine Adherence in Patients with Inflammatory Bowel Disease: A Qualitative Analysis

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