Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors

Simrén, Magnus; Axelsson, Jenny; Gillberg, R; Abrahamsson, Hasse; Svedlund, Jan; Bjõrnsson, Einar

doi:10.1111/j.1572-0241.2002.05475.x

Cited by 341 publications

(186 citation statements)

References 26 publications

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“…The patients with CD had undergone one or more of the following resections for clinical reasons; ileocekal resection (16), small intesinal resections (4) and/or partial colectomy (4). Both the small and large bowel were involved in 11 cases, only small intestine in 5 cases and only colon in 3 cases.…”

Section: Subjectsmentioning

confidence: 99%

“…Enteric ganglionitis has been found in some patients with severe IBS (3) and IBS symptoms are more frequent in patients with Crohn´s disease (CD) and ulcerative colitis (UC) than in the general population (4). In CD and UC, proliferation and injurious changes have sporadically been described in enteric smooth muscles, enteric nerves and ICCs (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enteric ganglioneuritis and abnormal interstitial cells of Cajal

Ohlsson

Veress

Lindgren

et al. 2007

Inflammatory Bowel Diseases

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Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enteric ganglioneuritis and abnormal interstitial cells of Cajal

Ohlsson

Veress

Lindgren

et al. 2007

Inflammatory Bowel Diseases

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“…17 Such symptoms are thought to occur in approximately 30% to 50% of patients with inactive IBD, a considerably higher prevalence than in healthy control subjects. [8][9][10][11][12][13][14][15][16] These findings are of considerable interest as we attempt to deepen our understanding of the inactive IBD disease state.…”

Section: Introductionmentioning

confidence: 99%

“…However, recent reports suggest that IBD can manifest IBS-like symptoms such as diarrhea and abdominal pain, even after bowel inflammation has been eliminated and the patient has entered clinical remission or mucosal lesions have healed. [8][9][10][11][12][13][14][15][16] This has been attributed to the persistence of microinflammation in the mucosa and to increased permeability of the gastrointestinal mucosa. 17 Such symptoms are thought to occur in approximately 30% to 50% of patients with inactive IBD, a considerably higher prevalence than in healthy control subjects.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

Tomita

Kato

Takimoto

et al. 2016

J Neurogastroenterol Motil

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Background/AimsFew studies are available that have investigated the risk factors for overlapping irritable bowel syndrome (IBS)-like symptoms in patients with inactive inflammatory bowel disease (IBD). The present study has 3 objectives: (1) to assess the prevalence of IBS-like symptoms in Japanese patients with inactive IBD using Rome III criteria, (2) to examine the relationship of IBS-like symptoms to health related quality of life (HR-QOL), and (3) to investigate associations for developing IBS-like symptoms in patients with inactive IBD. MethodsIBS-like symptoms were evaluated using the Rome III questionnaire for functional gastrointestinal disorders. HR-QOL and hospital anxiety and depression scale were evaluated. Results IBS-like symptoms were found in 17.5% (7/40) of patients with inactive ulcerative colitis, 27.1% (29/107) of patients with inactive Crohn's disease (CD), and 5.3% (23/438) of healthy control subjects. The QOL level was significantly lower and anxiety score was significantly higher in inactive CD patients with IBS-like symptoms than in those without such symptoms (P = 0.003, P = 0.009). Use of anti-anxiety drugs was associated with the presence of IBS symptoms (P = 0.045). HR-QOL score was lower and anxiety score was higher in patients with inactive ulcerative colitis, but the difference was not statistically significant. ConclusionsThe prevalence of IBS-like symptoms in inactive IBD patients was significantly higher than in healthy controls. Inactive CD patients with IBS-like symptoms has low QOL and anxiety; suggesting that anxiety may be associated with symptom development in such patients.

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“…Even during periods of remission, patients' wellbeing and psychological functioning tend to be poorer in comparison with the normal population (Blondel-Kucharski et al, 2001;Graff et al, 2009). Impaired quality of life in IBD is associated with more relapses and additional medical complications, intensifying the disease process in a cycle of inflammation and psychological suffering (e.g., Levenstein, 2004;Simren et al, 2002).…”

Section: What Does This Study Add?mentioning

confidence: 99%

The longitudinal effects of emotion regulation on physical and psychological health: A latent growth analysis exploring the role of cognitive fusion in inflammatory bowel disease

Trindade

Ferreira

Pinto‐Gouveia

2017

British J Health Psychol

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Objective. This study thus aims to test differences between patients with inflammatory bowel disease (IBD) regarding IBD symptomatology, cognitive fusion, and psychological and physical health, as well as to explore whether the maladaptive emotion regulation process of cognitive fusion longitudinally impacts on the baseline and evolution of these outcomes over a period of 18 months.Design and methods. Participants include 116 IBD patients with a mean age of 36.76 (SD = 11.39) of both genders (69.83% females) that completed the self-report measures of interest in three different times, equally spaced 9 months apart, over a period of 18 months. Latent growth curve models were conducted using structural equation modelling to estimate the growth trajectory of the variables in study.Results. Inflammatory bowel disease symptomatology and cognitive fusion's levels were negatively associated with psychological health and physical health's baseline levels. Furthermore, IBD symptomatology did not influence the growth of psychological health, while cognitive fusion did (b = .30, p = .007). The same result was found for physical health (b = .26, p = .024). These findings indicate that individuals with higher levels of cognitive fusion present lower levels of psychological health and physical health that tend to further decrease over the time through the effects of this maladaptive emotion regulation process.Conclusions. This study implies that it is of crucial importance to include psychotherapeutic interventions in the health care of patients with IBD. If successful, these interventions could represent decreases in the cost of IBD treatment and in the use of drugs with adverse side effects, in addition to improving patients' mental health and quality of life. Further implications for clinical and research work are discussed. Statement of contributionWhat is already known on this subject?Research has demonstrated the impact of emotion regulation on both physical and mental health. Nevertheless, the longitudinal effects of the specific emotion regulation process of cognitive fusion on physical and psychological health have never been explored.

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Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors

Cited by 341 publications

References 26 publications

Enteric ganglioneuritis and abnormal interstitial cells of Cajal

Enteric ganglioneuritis and abnormal interstitial cells of Cajal

Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

The longitudinal effects of emotion regulation on physical and psychological health: A latent growth analysis exploring the role of cognitive fusion in inflammatory bowel disease

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