Quality of life in long-term oral cancer survivors: an 8-year prospective study in China

Yan, Ying-Bin; Li, Meng; Liu, Zi-Quan; Xu, Jiabin; Liu, Hao; Shen, Jun; Zhang, Xuewei; Peng, Xin; Mao, Chi

doi:10.1016/j.oooo.2016.09.006

Cited by 18 publications

(30 citation statements)

References 34 publications

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“…Extrapolating these results, patients with retroperitoneal sarcoma exhibited a temporal increasing trend of QOL scores post-surgery and returned to baseline. Similar results have also been reported in other malignancies such as peritoneal carcinomatosis and oral cancers [ 23 , 24 , 27 , 28 ].…”

Section: Discussionsupporting

confidence: 88%

“…Extrapolating these results, patients with retroperitoneal sarcoma exhibited a temporal increasing trend of QOL scores postsurgery and returned to baseline. Similar results have also been reported in other malignancies such as peritoneal carcinomatosis and oral cancers [23,24,27,28]. Our study has several limitations, including the retrospective nature, small sample size and different followup time points of included patients.…”

Section: Discussionsupporting

confidence: 84%

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Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population

Lim

Ong

Skanthakumar

et al. 2020

Health Qual Life Outcomes

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Background: Retroperitoneal sarcoma represents 15% of sarcomas. The mainstay of treatment is surgery where a majority of patients require multi-visceral resections that may significantly impact their quality of life (QOL) following surgery. Studies in other cancers have shown that QOL may not be significantly impacted after radical or extensive surgery. However, there are limited studies examining the QOL specifically in patients with retroperitoneal sarcoma. In this pilot study, we retrospectively evaluated the QOL of patients with retroperitoneal sarcoma. Methods: 32 out of 90 patients who underwent surgical intervention for retroperitoneal sarcoma in National Cancer Centre Singapore from January 1999 to August 2018 who were alive and on follow-up were included in this study. EORTC-QLQ-C30 was administered to the patients. Results: The median age of our patients was 59 years (range, 35-84), and median time from surgery to the implementation of questionnaire was 2.5 years (range, 0.05-9.6). Younger patients had significantly better differences in global health, physical and role functioning scores as compared to older individuals. Female patients reported higher global health, physical, emotional and social functioning scores than males. Patients who were more than 2 years post-surgery exhibited better QOL scores as compared to those who had more recent surgery. Our patients had comparable global health and functioning scores compared to a reference group of outpatient cancer patients at our institution. Conclusions: Our pilot study investigating the QOL of patients with retroperitoneal sarcoma has shown that patients need to be followed up for at least 2 years following surgery to evaluate their QOL. In general, they achieved better functioning scores when compared with other cancer patients. These findings support the need for larger-scale prospective studies to further evaluate the QOL of these patients.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 84%

Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population

Lim

Ong

Skanthakumar

et al. 2020

Health Qual Life Outcomes

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“…Patients who completed radiotherapy less than 22 months earlier had a poorer quality of life on the physical pain domain than those who had completed therapy more than 22 months earlier. Researchers have evaluated quality of life at different times after the end of therapy in oral and oropharyngeal cancer survivors, and report improvements in the period of one to 8 years, although this pattern is not linear over time . Yan et al evaluated patients for 8 years and noted that long‐term survivors, in general, had quality of life improved, but some treatment‐related problems persisted.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have evaluated quality of life at different times after the end of therapy in oral and oropharyngeal cancer survivors, and report improvements in the period of one to 8 years, although this pattern is not linear over time . Yan et al evaluated patients for 8 years and noted that long‐term survivors, in general, had quality of life improved, but some treatment‐related problems persisted. In that study, most long‐term survivors had early‐stage tumor and were not treated with radiotherapy, unlike the sample analyzed in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Yan et al evaluated patients for 8 years and noted that long‐term survivors, in general, had quality of life improved, but some treatment‐related problems persisted. In that study, most long‐term survivors had early‐stage tumor and were not treated with radiotherapy, unlike the sample analyzed in the present study. This might help explain the difference between the results found in both studies and suggests that long‐term follow‐up of the patient who was treated with radiotherapy is necessary.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and sociodemographic factors associated with oral health‐related quality of life in survivors of head and neck cancer

et al. 2020

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Background: Factors related to head and neck cancer and the treatment of the disease can affect quality of life. The aim of this study was to determine factors associated with the severity of impact on oral health-related quality of life (OHRQoL) in survivors of head and neck cancer using a multivariate analysis. Methods: This cross-sectional study evaluated 90 volunteers who had completed radiotherapy at least 3 months earlier. OHRQoL was assessed using oral health impact profile (OHIP-14) and the data were analyzed using robust variance poisson regression models. Results: The mean total OHIP-14 score was 23.98 ± 12.55. Patients with hyposalivation had 56% higher (worse) mean OHIP-14 total scores (CI:1.11-2.18) and patients with advanced stage tumors had 31% higher mean OHIP-14 total scores (CI:1.03-1.66) in multivariate analyses.Conclusion: OHRQoL of survivors of head and neck cancer experienced a negative impact following radiotherapy. The impact was associated with hyposalivation and advanced stage tumors. K E Y W O R D Shead and neck neoplasms, radiotherapy, quality of life, xerostomia, oral health

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Long‐term health‐related quality of life in head and neck cancer survivors: A large multinational study

Taylor,

Amdal,

Bjordal

et al. 2024

Intl Journal of Cancer

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Head and neck cancer (HNC) patients suffer from a range of health‐related quality of life (HRQoL) issues, but little is known about their long‐term HRQoL. This study explored associations between treatment group and HRQoL at least 5 years' post‐diagnosis in HNC survivors. In an international cross‐sectional study, HNC survivors completed the European Organization for Research and Treatment of Cancer (EORTC) quality of life core questionnaire (EORTC‐QLQ‐C30) and its HNC module (EORTC‐QLQ‐H&N35). Meaningful HRQoL differences were examined between five treatment groups: (a) surgery, (b) radiotherapy, (c) chemo‐radiotherapy, (d) radiotherapy ± chemotherapy and neck dissection and (e) any other surgery (meaning any tumour surgery that is not a neck dissection) and radiotherapy ± chemotherapy. Twenty‐six sites in 11 countries enrolled 1105 survivors. They had a median time since diagnosis of 8 years, a mean age of 66 years and 71% were male. After adjusting for age, sex, tumour site and UICC stage, there was evidence for meaningful differences (10 points or more) in HRQoL between treatment groups in seven domains (Fatigue, Mouth Pain, Swallowing, Senses, Opening Mouth, Dry Mouth and Sticky Saliva). Survivors who had single‐modality treatment had better or equal HRQoL in every domain compared to survivors with multimodal treatment, with the largest differences for Dry Mouth and Sticky Saliva. For Global Quality of Life, Physical and Social Functioning, Constipation, Dyspnoea and Financial Difficulties, at least some treatment groups had better outcomes compared to a general population. Our data suggest that multimodal treatment is associated with worse HRQoL in the long‐term compared to single modality.

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Quality of life in long-term oral cancer survivors: an 8-year prospective study in China

Cited by 18 publications

References 34 publications

Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population

Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population

Clinical and sociodemographic factors associated with oral health‐related quality of life in survivors of head and neck cancer

Long‐term health‐related quality of life in head and neck cancer survivors: A large multinational study

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