Quality of life in multiple sclerosis: The differential impact of motor and cognitive fatigue

Ruban, Sabina David; Hilt, Claudia; Petersen, Thor

doi:10.1177/2055217321996040

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…Fatigue is defined as a subjective lack of physical and/or mental energy. MS-related fatigue is divided into physical and cognitive ( 4 ). Physical fatigue, defined as a decline in motor performance during sustained muscle activity, is caused by physical exhaustion and results from muscle weakness.…”

Section: Introductionmentioning

confidence: 99%

“…Physical fatigue, defined as a decline in motor performance during sustained muscle activity, is caused by physical exhaustion and results from muscle weakness. Cognitive fatigue is defined as a decline in performance during cognitive activity, which results from difficulty with concentration, memory loss, and emotional instability ( 4 – 8 ). Cognitive fatigue starts independently from the physical disability in the early stages of MS and may be present already in the prediagnostic phase of the disease ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

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Co-occurrence of Fatigue and Depression in People With Multiple Sclerosis: A Mini-Review

et al. 2022

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Fatigue and depression are common conditions diagnosed in people with multiple sclerosis (MS). Fatigue defined as subjective lack of physical and/or mental energy is present in 35–97% of people with MS, who classify it as one of the most serious symptoms interfering with daily activities and influencing the quality of life. Depression is diagnosed in about 50% of people with MS. Since fatigue and depression frequently coexists, it may be quite hard to differentiate them. Primary fatigue and primary depression in MS are caused by inflammatory, oxidative/nitrosative, and neurodegenerative processes leading to demyelination, axonal damage, and brain atrophy. In people with MS and comorbid fatigue and/or depression there is reported increased serum and cerebrospinal fluid concentration of inflammatory mediators such as tumor necrosis factor, interleukins (IL-1a, IL-1b, IL-6), interferon γ and neopterin. Moreover, the brain atrophy of prefrontal, frontal, parietotemporal regions, thalamus, and basal ganglia was observed in people with MS with fatigue and/or depression. The secondary fatigue and secondary depression in people with MS may be caused by emotional factors, sleep disorders, pain, the coexistence of other diseases, and the use of medications. In some studies, the use of disease-modifying therapies positively influenced fatigue, probably by reducing the inflammatory response, which proves that fatigue and depression are closely related to immunological factors. In this mini-review, the pathogenesis, methods of evaluation and differentiation, and possible therapies for fatigue and depression in MS are discussed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Co-occurrence of Fatigue and Depression in People With Multiple Sclerosis: A Mini-Review

et al. 2022

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“…MS-related fatigue is divided into physical and cognitive fatigue [ 5 ]. Physical fatigue results from physical exhaustion due to muscle weakness [ 6 ]. Cognitive fatigue can already be present before MS is diagnosed and is defined as a deterioration in cognitive activities resulting from a loss of concentration and memory or emotional instability [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Neurogenic Lower Urinary Tract Symptoms, Fatigue, and Depression—Are There Correlations in Persons with Multiple Sclerosis?

Jaekel,

Watzek,

Nielsen

et al. 2023

Biomedicines

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The symptoms of multiple sclerosis (MS) frequently include fatigue, depression, and neurogenic lower urinary tract symptoms (LUTS), causing severe burdens on affected individuals. The relationships between these symptoms have not been intensively researched and there are no studies on the detailed influence of the different neurogenic LUTS. We aimed to investigate the relationships between fatigue, depression, and neurogenic LUTS as recorded in bladder diaries by persons with MS. We analyzed the bladder diaries of 274 people and their scores on the Fatigue Scale for Motor and Cognitive Functions and the Centre for Epidemiologic Studies Depression Scale (German version). The neurogenic LUTS were defined as urgency, reduced voided volume, increased standardized voiding frequency, nocturia, and urinary incontinence. Those suffering from incontinence, nocturia, reduced voided volume, or urgency had higher fatigue scores compared to those without these symptoms. Those with nocturia showed significantly higher scores for depression. The severity of urgency and voided volume had the greatest effect on the severity of individuals’ fatigue and depression levels. With increasing urgency, the risk of clinically significant fatigue and depression was expected to increase. Urgency and voided volume correlated most with fatigue and depression. A prospective longitudinal study investigating fatigue/depression after the successful treatment of neurogenic LUTS is needed to clarify causality and offer possible treatment options for fatigue and depression.

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Relationship between disability and psychiatric outcome in multiple sclerosis patients and its determinants

Hassan,

Darwish,

Ahmed

et al. 2023

Egypt J Neurol Psychiatry Neurosurg

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Background Multiple sclerosis (MS) is an inflammatory demyelinating central nervous system disease with diverse clinical manifestations. The present study aimed to compare the psychiatric outcomes of MS patients with full ambulatory versus impaired ambulatory function and identify the potential risk factors for disability in MS. Seventy MS patients were classified into two groups based on their Expanded Disability Status Scale (EDSS) scores, Group A: full ambulatory (EDSS ≤ 4.5) (N = 48), Group B: impaired ambulatory (EDSS ≥ 5) (N = 22). All participants were evaluated by the Socioeconomic Scale, Hamilton Anxiety Scale, Hamilton Depression Scale, Brief Psychiatric Rating Scale, and The Pittsburgh Sleep Quality Index. Results In the total cohort (N = 70), females represented (77.1%). The mean age was 31.16 ± 6.46, the mean age of onset was 26 ± 6.083, and the mean disease duration was 5.33 ± 3.653 years which was less in Group A than in Group B. Relapsing–remitting multiple sclerosis (RRMS) was the most common presentation (80%), representing 93.6% of Group A. Group A reported more severe depression and anxiety, while Group B had more poor sleep quality. Correlation analysis showed increased relapses, progressive-relapsing multiple sclerosis (PRMS), cervical or dorsal plaques, sensory or motor manifestations, and precipitancy increased disability, while RRMS type decreased disability. Conclusions Full ambulatory MS patients had high anxiety and depression, while impaired ambulatory MS patients had poor sleep quality. Associated factors for disability were frequent relapses, plaque location, MS subtype, sphincter, and sensory symptoms. Trial registration clinicaltrials.gov, NCT05029830. Registered: September 01, 2021, https://clinicaltrials.gov/ct2/show/NCT05029830

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Quality of life in multiple sclerosis: The differential impact of motor and cognitive fatigue

Cited by 3 publications

References 36 publications

Co-occurrence of Fatigue and Depression in People With Multiple Sclerosis: A Mini-Review

Co-occurrence of Fatigue and Depression in People With Multiple Sclerosis: A Mini-Review

Neurogenic Lower Urinary Tract Symptoms, Fatigue, and Depression—Are There Correlations in Persons with Multiple Sclerosis?

Relationship between disability and psychiatric outcome in multiple sclerosis patients and its determinants

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