Quality of life in nonfunctioning pituitary macroadenoma patients before and after surgical treatment

Tanemura, Eriko; Nagatani, Tetsuya; Aimi, Yuri; Kishida, Yugo; Takeuchi, Kazuhito; Wakabayashi, Toshihiko

doi:10.1007/s00701-012-1473-3

Cited by 28 publications

(31 citation statements)

References 31 publications

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“…21 Tanemura et al concluded that patients experience a decrease in physical scores 1 month after the operation while experiencing an increase in mental scores. 28 They further reported that by 6 months patients recover to the level of the normal population in physical scores and remain stable in increased mental scores. Both of these studies were conducted on patients who underwent a pure endoscopic transsphenoidal approach.…”

Section: Sf-36 Progressionmentioning

confidence: 94%

“…Patients with pituitary adenomas report diminished QOL both before 16,28 and after treatment. 7,28,29 Factors related to a decrease in self-reported QOL include radiotherapy, pituitary surgery, and pituitary deficiencies as well as disease-specific effects of having a pituitary adenoma.…”

Section: Sf-36 Progressionmentioning

confidence: 99%

“…7,28,29 Factors related to a decrease in self-reported QOL include radiotherapy, pituitary surgery, and pituitary deficiencies as well as disease-specific effects of having a pituitary adenoma. Studies have clearly documented hypersecreting disease-specific impairments, particularly in acromegaly and Cushing's patients.…”

Section: Sf-36 Progressionmentioning

confidence: 99%

“…To eliminate this issue, we chose to limit the current study to patients with nonfunctioning adenomas (NFAs). Furthermore, while prior studies have assessed patient QOL at different time points after endoscopic surgery, 8,20,21,28 no other studies to our knowledge have examined the differences in QOL and sinonasal outcomes of microscopic and endoscopic surgery for defined time points in a concurrent series of patients at the same institution.…”

mentioning

confidence: 99%

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Prospective comparison of sinonasal outcomes after microscopic sublabial or endoscopic endonasal transsphenoidal surgery for nonfunctioning pituitary adenomas

Pledger¹,

Elzoghby

Oldfield³

et al. 2016

JNS

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obJective Both endoscopic and microscopic transsphenoidal approaches are accepted techniques for the resection of pituitary adenomas. Although studies have explored patient outcomes for each technique individually, none have prospectively compared sinonasal and quality of life outcomes in a concurrent series of patients at the same institution, as has been done in the present study. methods Patients with nonfunctioning adenomas undergoing transsphenoidal surgery were assessed for sinonasal function, quality of life, and pain using the Sino-Nasal Outcome , the short form of the Nasal Obstruction Symptom Evaluation (NOSE) instrument, the SF-36, and a headache scale. Eighty-two patients undergoing either endoscopic (47 patients) or microscopic (35 patients) surgery were surveyed preoperatively and at 24-48 hours, 2 weeks, 4 weeks, 8 weeks, and 1 year after surgery. results Patients who underwent endoscopic and microscopic transsphenoidal surgery experienced a similar recovery pattern, showing an initial increase in symptoms during the first 2 weeks, followed by a return to baseline by 4 weeks and improvement beyond baseline functioning by 8 weeks. Patients who underwent endoscopic surgery experienced better sinonasal outcomes at 24-48 hours (SNOT total p = 0.015, SNOT rhinologic subscale [ssRhino] p < 0.001), 2 weeks (NOSE p = 0.013), and 8 weeks (SNOT total p = 0.032 and SNOT ssRhino p = 0.035). By 1 year after surgery, no significant differences in sinonasal outcomes were observed between the 2 groups. Headache scales at 1 year improved in all dimensions except duration for both groups (total result 73%, p = 0.004; severity 46%, p < 0.001; frequency 53%, p < 0.001), with 80% of either microscopic or endoscopic patients experiencing improvement or resolution of headache symptoms. Endoscopic and microscopic patients experienced reduced vitality preoperatively compared with US population norms and remained low postoperatively. By 8 weeks after surgery, both groups experienced significant improvements in mental health (13%, p = 0.005) and vitality (15%, p = 0.037). By 1 year after surgery, patients improved significantly in mental health (14%, p = 0.03), role physical (14%, p = 0.036), social functioning (16%, p = 0.009), vitality (22%, p = 0.002), and SF-36 total (10%, p = 0.024) as compared with preoperative measures. There were no significant differences at any time point between the 2 groups for the total SF-36 or for any of the 8 subscales. coNclusioNs Patients who underwent either an endoscopic or a microscopic approach experienced the greatest nasal symptoms at 2 weeks postoperatively and exhibited similar time courses of recovery in nasal, headache, and quality of life assessments. Although patients who underwent endoscopic surgery experienced significantly fewer nasal symptoms during the first 8 weeks, by 1 year after surgery, there were no significant differences between the 2 groups.

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Section: Sf-36 Progressionmentioning

confidence: 94%

Section: Sf-36 Progressionmentioning

confidence: 99%

Section: Sf-36 Progressionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Prospective comparison of sinonasal outcomes after microscopic sublabial or endoscopic endonasal transsphenoidal surgery for nonfunctioning pituitary adenomas

Pledger¹,

Elzoghby

Oldfield³

et al. 2016

JNS

View full text Add to dashboard Cite

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“…A prospective Japanese study ( n = 30, 80% with impaired visual function) demonstrated that impaired preoperative visual function in NFPA correlated with worse SF‐36 scores (four of eight subscales) before surgery. After successful surgery, only one patient (3%) had visual impairment, and postoperatively SF‐36 scores (physical component summary) significantly improved . Another prospective study similarly reported significant postoperative improvements and restoration of vision‐related quality of life, in patients with NFPAs .…”

Section: Discussionmentioning

confidence: 89%

Health‐related quality of life in patients treated for nonfunctioning pituitary adenomas during the years 2000–2010

Karppinen

Ritvonen

Roine

et al. 2015

Clinical Endocrinology

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Prospective evaluation of multidimensional health‐related quality of life after endoscopic endonasal surgery for pituitary adenomas using the endoscopic endonasal sinus and skull base surgery questionnaire

Joustra

Dam

Vermeulen

et al. 2023

Laryngoscope Investig Oto

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Objective: Social functioning is an important factor in the evaluation of postoperative health-related quality of life (HRQoL) for pituitary adenoma patients. In a prospective cohort study multidimensional HRQoL of non-functioning (NFA) and functioning (FA) pituitary adenoma patients were evaluated following endoscopic endonasal surgery using the endoscopic endonasal sinus and skull base surgery questionnaire (EES-Q).Methods: Prospectively, 101 patients were included. The EES-Q was completed preoperatively and postoperatively (2 weeks, 3 months, 1 year). Sinonasal complaints were completed daily during the first week postoperatively. Preoperative and postoperative scores were compared. A generalized estimating equation (uni-and multivariate) analysis was performed to identify significant HRQoL changes related to selected covariates.Results: Two weeks postoperatively, physical (p < .05) and social (p < .05) HRQoL are worse and psychological (p < .05) HRQoL improved compared with preoperatively.Three months postoperatively, psychological HRQoL (p = .01) trended back to baseline and no differences in physical or social HRQoL were reported. One year postoperatively, psychological (p = .02) and social (p = .04) HRQoL improved while physical HRQoL remained stable. FA patients report a worse HRQoL preoperatively (social, p < .05) and 3 months postoperatively (social, p < .02 and psychological, p < .02).Sinonasal complaints peak in the first days postoperatively and gradually return to presurgical levels 3 months postoperatively. Conclusions:The EES-Q provides meaningful information on multidimensional HRQoL to improve patient-centred health care. Social functioning remains the most difficult area in which to achieve improvements. Despite the relatively modest sample size, there is some indication that the FA group continues to show a downward

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Quality of life in nonfunctioning pituitary macroadenoma patients before and after surgical treatment

Cited by 28 publications

References 31 publications

Prospective comparison of sinonasal outcomes after microscopic sublabial or endoscopic endonasal transsphenoidal surgery for nonfunctioning pituitary adenomas

Prospective comparison of sinonasal outcomes after microscopic sublabial or endoscopic endonasal transsphenoidal surgery for nonfunctioning pituitary adenomas

Health‐related quality of life in patients treated for nonfunctioning pituitary adenomas during the years 2000–2010

Prospective evaluation of multidimensional health‐related quality of life after endoscopic endonasal surgery for pituitary adenomas using the endoscopic endonasal sinus and skull base surgery questionnaire

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