Quality of Life in Patients with Uraemic Xerosis and Pruritus

Szepietowski, Jacek C.; Balaskas, Elias V.; Taube, Klaus-Michael; Taberly, Alain; Dupuy, P

doi:10.2340/00015555-1075

Cited by 56 publications

(22 citation statements)

References 3 publications

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“…29,30 Its mean prevalence of 72% in our cohort is in keeping with those earlier results. Xerosis cutis is caused by atrophy of sweat- and sebaceous-glands and disturbed dermal hydration, at times attributed to the use of diuretics.…”

Section: Review Of Findingssupporting

confidence: 93%

Edema, Hyperpigmentation, Induration

et al. 2016

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Skin changes are common in patients on dialysis. This study focused on putative associations of specific skin findings with comorbidities and mortality.We performed a retrospective analysis of data from 508 patients on maintenance hemodialysis therapy in 7 centers in the German State of North Rhine Westphalia. Data had been collected by interview, from patient files, and from targeted physical examination in an earlier prospective study screening hemodialysis patients for the presence of nephrogenic systemic fibrosis. While on dialysis, patients’ extremities had been examined for any of the following: edematous skin at the lower extremities, hyperpigmentation, induration, and xerosis cutis. Our present data analyses focused on associated mortality and comorbidities.Five hundred eight patients (median age 71 years, range 20.0–95.9; n = 292 men) had agreed to participate in the initial study: 48% (n = 243) were diabetics and 46% (n = 232) had been diagnosed with coronary heart disease. On examination, 86% of patients (n = 439) presented with at least 1 of the prespecified skin changes. Skin edema (n = 89; 18%), hyperpigmentation (n = 74; 15%), and induration (n = 9; 2%) were independently associated with increased mortality over 24 months (P < 0.002, P < 0.030, and P < 0.020, respectively).In our study, prespecified skin changes indicated an increased mortality risk in patients on chronic hemodialysis. Routinely assessing the skin of dialysis patients represents a simple, reliable, and cost effective means of identifying those at greatest risk.

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Section: Review Of Findingssupporting

confidence: 93%

Edema, Hyperpigmentation, Induration

et al. 2016

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“…The patients who reported pruritus experienced a greater impact on QoL compared to non-pruritic ESRD patients ( p < 0.001). The investigators found that age and pruritus intensity, but not xerosis, independently contributed to DLQI deterioration ( p < 0.001) (Szepietowski et al 2011).…”

Section: End-stage Renal Diseasementioning

confidence: 99%

“…(Chen 2012;Finlay and Khan 1994). Investigators have used DLQI to evaluate the impact of pruritus on QoL in multiple studies, including research into ESRD (Szepietowski et al 2011) and vitiligo (Silverberg and Silverberg 2013). A pediatric version of the DLQI, the Children's Dermatology Life Quality Index (CDLQI), has been created as well.…”

Section: Instruments To Measure the Impact Of Pruritus On Qolmentioning

confidence: 99%

Pruritus Epidemiology and Quality of Life

Leader¹,

Carr²,

Chen³

2015

Handbook of Experimental Pharmacology

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The burden of chronic pruritus is increasingly recognized as significant worldwide. As wet-laboratory researchers investigate the pathophysiology of chronic pruritus, epidemiologists and health services researchers are quantifying the impact of pruritus by incidence, prevalence, and quality of life measures. Outcomes researchers are also investigating factors that may predict chronic pruritus incidence and severity. Such efforts will direct resources for research, public health intervention, and clinical care.

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“…Thus, damage to the skin among ESRD patients receiving dialysis or renal replacement therapy is most likely due to UP. In addition to these anatomical consequences, UP has a major impact on the sleep quality and the psychosocial and social wellbeing of the patients91011. With continuous research in the basic health sciences, the UP prevalence has declined compared to the past.…”

mentioning

confidence: 99%

An Observational Longitudinal Study Investigating the Effectiveness of 75 mg Pregabalin Post-Hemodialysis among Uremic Pruritus Patients

Khan

Goh

et al. 2016

Sci Rep

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A prospective, observational, longitudinal study was conducted to assess the effectiveness of 75 mg pregabalin (PG) post-hemodialysis (pHD) for treatment-resistant uremic pruritus (UP). A total of forty-five patients completed the entire six week follow-up. At the baseline assessment, the majority of the patients were distressed by the UP frequency and intensity. Sleep (mean = 3.30 ± 1.1), leisure/social activities (mean = 2.90 ± 0.80) and distribution (mean = 2.92 ± 0.34) were the three domains that were primarily effected by the UP. Overall, further reduction in the 5D-itching scale (IS) was noted at day 42, which confirmed a sustained (B = −12.729, CI −13.257 to −12.201, p < 0.001) relief of pruritus severity among patients with treatment-resistant pruritus. Patients with a higher serum calcium level had a score difference of +1 from the other patients (B = 1.010, p = 0.061). There was a reduction of 12 points compared to the baseline 5D-IS for each patient on day 42 after using pregabalin 75 mg PD pHD for 42 days, which represented major relief. Among the demographic factors, only gender was significantly associated with the 5D-IS score.

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Quality of Life in Patients with Uraemic Xerosis and Pruritus

Cited by 56 publications

References 3 publications

Edema, Hyperpigmentation, Induration

Edema, Hyperpigmentation, Induration

Pruritus Epidemiology and Quality of Life

An Observational Longitudinal Study Investigating the Effectiveness of 75 mg Pregabalin Post-Hemodialysis among Uremic Pruritus Patients

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