Quality of life in patients with age-related macular degeneration: results from the VISION study

Leys, Anita; Zlateva, Gergana; Shah, Sonali; Patel, Manju

doi:10.1038/sj.eye.6702900

Cited by 32 publications

(17 citation statements)

References 25 publications

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“…The NEI VFQ-25 composite scores observed in the present study were lower than those reported for patients with PDR, SMD, or Behçet's disease in other studies (8,18,19) . Our patients were younger than those in other studies; therefore, young individuals may experience a greater impact on their QOL with permanent vision loss due to trauma than with other diseases.…”

Section: Discussioncontrasting

confidence: 55%

Vision-related quality of life in patients after ocular penetrating injuries

Yüksel¹,

Türkçü²,

ahin³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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Section: Discussioncontrasting

confidence: 55%

Vision-related quality of life in patients after ocular penetrating injuries

Yüksel¹,

Türkçü²,

ahin³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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“…Pharmacotherapy with pegaptanib, ranibizumab, and intravitreal aflibercept have all demonstrated significant improvements in QoL composite score on the NEI VFQ-25, indicating overall improvement in the respondent’s visual health and related functional capacities 13,14,25,26. Other benefits, such as a reduction in the incidence of depression or a decrease in injuries due to falls (a major hazard of vision loss), may also be reflected in improved QoL scores 3,12.…”

Section: Resultsmentioning

confidence: 99%

Assessing quality of life in the treatment of patients with age-related macular degeneration: clinical research findings and recommendations for clinical practice

Yuzawa¹,

Fujita²,

Tanaka³

et al. 2013

OPTH

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BackgroundThe importance of incorporating quality-of-life (QoL) assessments into medical practice is growing as health care practice shifts from a “disease-based” to a “patient-centered” model. The prevalence of age-related macular degeneration (AMD) is increasing in today’s aging population. The purpose of this paper is: (1) to discuss, by reviewing the current literature, the impact of AMD on patients’ QoL and the utility of QoL assessments in evaluating the impact of AMD and its treatment; and (2) to make a recommendation for incorporating QoL into clinical practice.MethodsWe conducted a PubMed and an open Internet search to identify publications on the measurement of QoL in AMD, as well as the impact of AMD and the effect of treatment on QoL. A total of 28 articles were selected.ResultsAMD has been found to cause a severity-dependent decrement in QoL that is comparable to systemic diseases such as cancer, ischemic heart disease, and stroke. QoL impairment manifests as greater social dependence, difficulty with daily living, higher rates of clinical depression, increased risk of falls, premature admission to nursing homes, and suicide. The National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) is the most widely used eye disease-specific QoL instrument in AMD. It has been shown to correlate significantly with visual acuity (VA). QoL reflects aspects of AMD including psychological well-being, functional capacity, and the ability to perform patients’ valued activities, which are not captured by a single, numerical VA score.ConclusionThe literature shows that the adverse impact of AMD on QoL is comparable to serious systemic disease. Eye disease-specific instruments for measuring QoL, such as the NEI VFQ-25, have shown a significant correlation of QoL decrement with measures of disease severity, as well as significant QoL improvement with treatment. The NEI VFQ-25 and other validated instruments provide a wide-ranging assessment of vision-related functioning that is important to patients and complementary to VA measurement. We strongly recommend the incorporation of QoL assessment into routine clinical practice.

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“…They have been validated by a variety of studies showing they are useful tools in assessing vision-specific quality of life [4–8]. NEI VFQ-25 is demonstrated to be sensitive to the influence of age related macular degeneration (AMD) [9, 10], glaucomatous field loss [11], cataract [12], Behcet uveitis [13], after penetrating keratoplasty for keratoconus [14], after retinal detachment surgery [15], vitrectomy [16], diabetic retinopathy [17], strabismus [18], multiple sclerosis [19], osteoporotic fractures, and low vision from any cause [20]. The correlations with clinical markers of disease severity provide evidence of clinical validity for the measure.…”

Section: Introductionmentioning

confidence: 99%

Vision Related Quality of Life in Patients with Keratoconus

Kurna

Altun

Gencaga

et al. 2014

Journal of Ophthalmology

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Purpose. The purpose of this study is to evaluate the vision related quality of life in patients with keratoconus by using the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25). Methods. Thirty patients presented with keratoconus (keratoconus group) and 30 healthy patients (control group) were included in this study. Twenty patients were using rigid gas permeable and 10 patients were not using contact lenses in keratoconus group. High and low contrast visual acuity and mean K values of the patients were recorded. Each subject completed the 25-item NEI-VFQ-25. Results. All subscales of NEI-VFQ-25 were lower in the keratoconus patients. The difference was more evident in the subscales of general vision, ocular pain, near vision, vision-specific mental health, vision-specific role difficulties, and peripheral vision (P < 0.05). Overall composite score was 75.2 ± 17.2 in the keratoconus group and 93.2 ± 5.6 in the control group (P = 0.00). Contact lens wearers had higher best corrected visual acuity in comparison with noncontact lens wearers (P = 0.028). Patients with low visual acuity (logMAR > 0.4) in the better eye had lower distance vision, social functioning, mental health, and role difficulties. Meanwhile, patients with low visual acuity (logMAR > 0.4) in the worse eye had lower general health scores (P < 0.05). Conclusions. Vision related quality of life was worse in keratoconus patients. Success in the contact lens usage and maintaining higher visual acuity may improve vision related quality of life.

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Quality of life in patients with age-related macular degeneration: results from the VISION study

Cited by 32 publications

References 25 publications

Vision-related quality of life in patients after ocular penetrating injuries

Vision-related quality of life in patients after ocular penetrating injuries

Assessing quality of life in the treatment of patients with age-related macular degeneration: clinical research findings and recommendations for clinical practice

Vision Related Quality of Life in Patients with Keratoconus

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