Quality of life in patients with treated and clinically stable Wilson's disease

Svetel, Marina; Pekmezović, Tatjana; Tomić, Aleksandra; Kresojević, Nikola; Potrebić, Aleksandra; Jesic, Rada; Kostić, Vladimir

doi:10.1002/mds.23608

Cited by 31 publications

(25 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Behavioral and personality disturbances could lead to serious social problems, including family difficulties (divorces, unemployment, or even criminal activity), as well as difficulties receiving medical care, including treatment, diagnosis, and rehabilitation (issues include verbal aggression and non-compliance with anti-copper treatment as well as other medical recommendations). 10 , 69 Behavioral and personality problems can negatively affect treatment outcomes in WD, so it is important to assess them at the beginning of treatment and monitor them. 10 However, there are currently no data informing the treatment of these disturbances in WD patients.…”

Section: Psychiatric Symptoms Of Wdmentioning

confidence: 99%

“…The symptoms and diagnosis of an illness as serious as WD can be a major stressor, often leading to significant life changes, difficulties with normal functioning, and can lead to a decline in social and material status. 69 Many patients with WD suffer from various forms of adjustment disorders, manifesting as a mixture of anxiety, depression, worry, insomnia and tension, but also irritability, anger and conduct disorders. 10 Simple interventions such as psychoeducation, supportive psychotherapy, cognitive-behavioral therapy (CBT) and support groups might help to reduce anxiety and tension, and facilitate the development of good coping strategies to adapt to the new life situation of chronic illness.…”

Section: Psychiatric Symptoms Of Wdmentioning

confidence: 99%

See 1 more Smart Citation

Psychiatric manifestations in Wilson’s disease: possibilities and difficulties for treatment

Litwin

Dušek

Szafrański³

et al. 2018

Therapeutic Advances in Psychopharmacology

View full text Add to dashboard Cite

Wilson’s disease (WD) is an inherited metabolic disorder related to disturbances of copper metabolism, and predominantly presents with liver and neuropsychiatric symptoms. In most cases it can be successfully treated with anti-copper agents, and both liver function and neuropsychiatric symptoms typically improve. Treatment guidelines for WD include recommendations for anti-copper treatment as well as for the treatment of liver failure symptoms. Recently, recommendations for treatment of the neurological symptoms of WD have also been proposed. Although most WD patients present with psychiatric symptoms at some stage of the disease, currently there are no guidelines for the treatment of the psychiatric manifestations. Treatment of the psychiatric symptoms of WD is often guided by general psychiatric experience, which typically glosses over the specificity of WD, and can result in severe neurological and/or hepatic complications. Here we review and discuss the possible treatments available for the mood disturbances, psychosis, behavioral and cognitive disorders that can occur in WD, as well as their efficacy.

show abstract

Section: Psychiatric Symptoms Of Wdmentioning

confidence: 99%

Section: Psychiatric Symptoms Of Wdmentioning

confidence: 99%

Psychiatric manifestations in Wilson’s disease: possibilities and difficulties for treatment

Litwin

Dušek

Szafrański³

et al. 2018

Therapeutic Advances in Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Recently, Svetel et al [93] carried on a cross-sectional study to identify clinical and demographic factors influencing health-related QoL in 60 treated, clinically stable patients with WD using a generic questionnaire, the Medical Outcomes Study Short-Form 36-Item Health Survey [SF-36]. The level of disability and grading of WD severity were assessed by the Global Assessment Scale for WD [GAS for WD]; cognitive impairment and depressive features were assessed respectively by the Mini Mental State Examination [MMSE] and the 21-item Hamilton Depression Rating Scale [HDRS].…”

Section: Resultsmentioning

confidence: 99%

Quality of Life and Psychiatric Symptoms in Wilson’s Disease: the Relevance of Bipolar Disorders

Carta

Mura²,

Sorbello³

et al. 2012

CPEMH

View full text Add to dashboard Cite

Introduction:Wilson’s disease is an inherited disorder caused by a gene located on chromosome 13, which involved copper transportation across cell membranes. The disease can cause a reduced incorporation of copper into ceruloplasmin resulting in accumulation of this metal in the liver, central nervous system, kidneys and other organs. The objective is to define the frequencies of psychiatric disorders in WD, the amount of impairment of Quality of Life [QoL] in patients with WD and the relevance of the psychiatric disorders in the QoL of people suffering by WD.Methods:This is a systematic review. The search of the significant articles was carried out in PubMed using specific key words.Results:Such other neurological diseases, WD is characterized by chronic course and need of treatments, impairment of functional outcomes and high frequency of psychiatric symptoms, although a specific association between Bipolar Disorders and WD was recently found. Despite this, since today few studies are carried on WD patients’ quality of life related to psychiatric symptoms. Some new reports showed a link between presence of Bipolar Disorders diagnosis, cerebral damage and low Qol.Conclusion:Prospective studies on large cohorts are required to establish the effective impact of psychiatric disorders comorbidity, particularly Bipolar Disorders, on quality of life in WD and to clarify the causal link between brain damage, psychiatric disorders and worsening of QoL.

show abstract

“…[ 11 ] Table 3 provides an overview of the case reports about this issue. [ 10 11 13 15 19 20 21 22 23 24 25 26 27 28 29 30 44 45 46 47 48 49 50 ]…”

Section: Discussionmentioning

confidence: 99%

Misidentification of Wilson Disease as Schizophrenia (1998-2013): Case Report and Review

Elyasi¹

2017

Indian Journal of Psychological Medicine

View full text Add to dashboard Cite

Wilson's disease (WD) is a neurodegenerative disorder due to copper metabolism. Schizophrenia-like psychosis and delusional disorder are rare forms of psychiatric manifestations of WD. The lack of recognition of these signs and symptoms as being attributable to WD often leads to delays in diagnosis and management. Knowledge about relationship of the psychiatric manifestations to WD can help with the administration of adequate management aimed at both the psychiatric issues and underlying WD. The objectives of this article are to review case reports whose subject is the incorrect diagnosis of schizophrenia or schizophrenia-like syndrome in patients with WD and to detail one case of this mismanagement of the disease. A 35-year-old unmarried Iranian woman presented to the consulting psychiatrist in the emergency room after a suicide attempt due to commanding auditory hallucination. She had previous eleven admissions in psychiatric hospital with major depressive episode with psychotic features, schizoaffective disorders, and then schizophrenia diagnosis. Nineteen years after her first symptoms, it was discovered that the patient was suffering from WD. We searched Google Scholar, Ovid, PsycINFO, CINHAL, and PubMed databases from 1985 to 2015. Finally, 14 researches were entered into the study. Psychiatric manifestations may precede the diagnosis of WD and other symptoms related to neurological or hepatic impairment. Early detection of WD is important to prevent catastrophic outcome. Young patients presenting with psychiatric presentations along with abnormal movement disorder, seizure, or conversion-like symptoms should be evaluate for WD even if signs and symptoms are typically suggestive of schizophrenia or manic episode. An interdisciplinary approach with good collaboration of psychiatrists and neurologists is crucial for WD because early diagnosis and management without delay is an important for good prognosis.

show abstract

Quality of life in patients with treated and clinically stable Wilson's disease

Cited by 31 publications

References 20 publications

Psychiatric manifestations in Wilson’s disease: possibilities and difficulties for treatment

Psychiatric manifestations in Wilson’s disease: possibilities and difficulties for treatment

Quality of Life and Psychiatric Symptoms in Wilson’s Disease: the Relevance of Bipolar Disorders

Misidentification of Wilson Disease as Schizophrenia (1998-2013): Case Report and Review

Contact Info

Product

Resources

About