Quality of Life in Patients with Pituitary Tumors

Baird, Anne; Sullivan, T. J.; Sajjad, Zafar; Rock, Jack

doi:10.1097/00019514-200304000-00005

Cited by 21 publications

(12 citation statements)

References 10 publications

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“…Furthermore, the disease-specific bother of pituitary adenomas observed in this study is in accordance with previous literature, with patients with CD reporting the largest negative impact on QoL [ 7 , 35 , 36 ]. The LBNQ-Pituitary offers the possibility to assess bother and needs for support in people with pituitary disease in general with potential comorbid hypopituitarism, while it can also be used to assess aspects related to specific pituitary disease, such as CD or PRL.…”

Section: Discussionsupporting

confidence: 92%

The development and validation of the Leiden Bother and Needs Questionnaire for patients with pituitary disease: the LBNQ-Pituitary

et al. 2016

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BackgroundPatients report persisting impairment in quality of life (QoL) after treatment for pituitary disease. At present, there is no questionnaire to assess (a) whether patients with pituitary disease are bothered by these consequences, and (b) their needs for support.ObjectiveTo develop and validate a disease-specific questionnaire for patients with pituitary disease which incorporates patient perceived bother related to the consequences of the disease, and their needs for support.MethodsItems for the Leiden Bother and Needs Questionnaire for patients with pituitary disease (LBNQ-Pituitary) were formulated based on results of a recent focus group study (n = 49 items). 337 patients completed the LBNQ-Pituitary and six validated QoL questionnaires (EuroQoL-5D, SF-36, MFI-20, HADS, AcroQol, CushingQoL). Construct validity was examined by exploratory factor analysis. Reliabilities of the subscales were calculated with Cronbach’s alphas, and concurrent validity was assessed by calculating Spearman’s correlations between the LBNQ-Pituitary and the other measures.ResultsFactor analyses produced five subscales (i.e., mood problems, negative illness perceptions, issues in sexual functioning, physical and cognitive complaints, issues in social functioning) containing a total of 26 items. All factors were found to be reliable (Cronbach’s alphas all ≥.765), and the correlations between the dimensions of the LBNQ-Pituitary and other questionnaires (all P ≤ .0001) demonstrated convergent validity.ConclusionsThe LBNQ-Pituitary can be used to assess the degree to which patients are bothered by the consequences of the pituitary disease, as well as their needs for support. It could also facilitate an efficient assessment of patients’ needs for support in clinical practice. We postulate that paying attention to needs for support will lead to optimal patient care (e.g., improvement in psychosocial care), and positively affect QoL.Electronic supplementary materialThe online version of this article (doi:10.1007/s11102-016-0707-4) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 92%

The development and validation of the Leiden Bother and Needs Questionnaire for patients with pituitary disease: the LBNQ-Pituitary

et al. 2016

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“…Although previous studies have acknowledged that patients with pituitary tumors have an impaired QoL,11–14,18 only 1 study has investigated the overall QoL and specific domains that relate to the sinuses and rhinosinusitis in patients before and after undergoing MIPS 19. However, in that study, the primary goal was to compare a sublabial transseptal (SLTS) approach to an entirely endoscopic approach to pituitary tumors.…”

Section: Discussionmentioning

confidence: 99%

Recruiting Black/African American men for research on prostate cancer prevention

Woods

Montgomery

Herring

2004

Cancer

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Background: Endoscopic, endonasal, minimally invasive pituitary surgery (MIPS) has proven to be safe and efficacious. However, there are few data that assess the health‐related or sinonasal‐specific quality‐of‐life (QoL) of those undergoing MIPS. Our hypothesis is that patients undergoing MIPS do not have significantly different sinus disability or change in QoL after surgery compared to prior to surgery. Methods: This is a retrospective review of patients undergoing MIPS between 2002 and 2009. Rhinosinusitis Disability Index (RSDI) scores, patient demographics, tumor characteristics, surgical outcomes, and intraoperative/postoperative complications were recorded. Preoperative and postoperative mean RSDI scores and the mean absolute change in RSDI were calculated with 95% confidence intervals (CIs). One‐way analysis of variance (ANOVA) compared RSDI scores between different tumor subgroups. Results: A total of 50 patients completed the RSDI preoperatively and postoperatively. Analyses revealed no significant difference between preoperative and postoperative scores across all domains (p = 0.84). When the cohort was stratified into functional vs nonfunctional tumor types there was no significant difference between the 2 groups (p = 0.88). Data showed no statistically significant change in RSDI scores postoperatively in all groups. Conclusion: These data show that MIPS with appropriate postoperative care results in little or no long‐term sinonasal quality of life defects. © 2011 ARS‐AAOA, LLC.

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“…That does not account for the pain in all cases, as with patients with microadenomas, for example 5 . The headache and the hormonal disturbance are among the factors that contribute to worsen the quality of life in a large number of patients 6 . The relationship between increased ISP, visual changes and headache was object of studies in recent years 4,[7][8][9][10][11][12][13][14][15] , including in Brazil 16 .…”

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confidence: 99%

Mean intrasellar pressure, visual field, headache intensity and quality of life of patients with pituitary adenoma

Pereira-Neto

Borba

Mello

et al. 2010

Arq. Neuro-Psiquiatr.

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Intrasellar pressure (ISP) measurement technique has recently opened a new line of research in neuroendocrinology. The absolute and mean ISP values were investigated in 25 patients consecutively operated at the Brasilia University Hospital (DF). These data were correlated with serum prolactin levels, number of visual quadrant affected, tumor size, quality of life (measured through the SF-36 scale) and graded headache (measured through the HIT-6 scale). No correlation was observed. The p values were 0.887; 0.137; 0.892; 0.812 and 0.884; respectively. The HIT-6 values were inversely and moderately correlated with total RAND SF-36 and its mental and physical dimensions. Key words: pituitary adenoma, intrasellar pressure, headache.Pressão intra-selar média, campo visual, intensidade de cefaléia e qualidade de vida em portadores de adenoma hipofisário resumo A técnica da medida da pressão intra-selar (PIS) abriu, recentemente, uma nova linha de pesquisa em neuroendocrinologia. O objetivo deste estudo foi aferir os valores absolutos da PIS e calcular a pressão intra-selar média (PIM) em uma população de 25 pacientes operados consecutivamente no Hospital Universitário de Brasília (DF). Não se observou correlação significativa entre a PIM e o número de quadrantes visuais comprometidos (p=0,137), área do tumor (p=0,892), nível de qualidade de vida mensurado pela escala SF-36 (p=0,812) e a presença e a intensidade da cefaléia mensurada pela escala 884). Contudo, o HIT-6 correlacionou-se de forma inversa e intensidade moderada com os valores de HIT-6 e suas dimensões mental e física. Palavras-chave: adenoma hipofisário, pressão intraselar, cefaléia.Correspondence Paulo Andrade de Mello SMDB conjunto 7/casa 1

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Quality of Life in Patients with Pituitary Tumors

Cited by 21 publications

References 10 publications

The development and validation of the Leiden Bother and Needs Questionnaire for patients with pituitary disease: the LBNQ-Pituitary

The development and validation of the Leiden Bother and Needs Questionnaire for patients with pituitary disease: the LBNQ-Pituitary

Recruiting Black/African American men for research on prostate cancer prevention

Mean intrasellar pressure, visual field, headache intensity and quality of life of patients with pituitary adenoma

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