Quality of life in patients with established inflammatory bowel disease: a UK general practice survey

Rubin, Greg; Hungin, A. P. S.; Chinn, D. J.; Dwarakanath, D

doi:10.1111/j.1365-2036.2004.1873.x

Cited by 83 publications

(51 citation statements)

References 16 publications

(28 reference statements)

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“…Thus, if sequential scores deteriorate with time, this is a reliable indicator of disease activity producing gastrointestinal, systemic and psychological symptoms. This has been demonstrated both in a primary-care setting as well as in hospital practice (Guyatt et al, 1989;Yoshida, 1999;Cheung et al, 2000;Rubin et al, 2004). In other words, in the setting of benign inflammatory disease, this questionnaire is highly reliable, and while we have not tested the reproducibility of scores in patients with stable symptoms in this study, there is little reason to think that this group of patients should score change in symptoms differently to those with inflammatory bowel disease.…”

Section: Discussionmentioning

confidence: 86%

A modified Inflammatory Bowel Disease questionnaire and the Vaizey Incontinence questionnaire are simple ways to identify patients with significant gastrointestinal symptoms after pelvic radiotherapy

et al. 2005

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After radiotherapy for pelvic cancer, chronic gastrointestinal problems may affect quality of life (QOL) in 6 -78% of patients. This variation may be due to true differences in outcome in different diseases, and may also represent the inadequacy of the scales used to measure radiotherapy-induced gastrointestinal side effects. The aim of this study was to assess whether outcome measures used for nonmalignant gastrointestinal disease are useful to detect gastrointestinal morbidity after radiotherapy. Results obtained from a Vaizey Incontinence questionnaire and a modified Inflammatory Bowel Disease questionnaire (IBDQ) -both patient completed -were compared to those from a staff administered Late Effects on Normal Tissue (LENT) -Subjective, Objective, Management and Analytic (SOMA) questionnaire in patients who had completed radiotherapy for a pelvic tumour at least 3 months previously. In all, 142 consecutive patients were recruited, 72 male and 70 female, median age 66 years (range 26 -90 years), a median of 27 (range 3 -258) months after radiotherapy. In total, 62 had been treated for a gynaecological, 58, a urological and 22, a gastrointestinal tract tumour. Of these, 21 had undergone previous gastrointestinal surgery and seven suffered chronic gastrointestinal disorders preceding their diagnosis of cancer. The Vaizey questionnaire suggested that 27% patients were incontinent for solid stools, 35% for liquid stools and 37% could not defer defaecation for 15 min. The IBDQ suggested that 89% had developed a chronic change in bowel habit and this change significantly affected 49% patients: 44% had more frequent or looser bowel movements, 30% were troubled by abdominal pain, 30% were troubled by bloating, 28% complained of tenesmus, 27% were troubled by their accidental soiling and 20% had rectal bleeding. At least 34% suffered emotional distress and 22% impairment of social function because of their bowels. The small intestine/colon SOMA median score was 0.1538 (range 0 -1) and the rectal SOMA median score was 0.1428 (range 0 -1). Pearson's correlations for the IBDQ score and small intestine/colon SOMA score was À0.630 (Po0.001), IBDQ and rectum SOMA À0.616 (Po0.001), IBDQ and Vaizey scores À0.599 (Po0.001), Vaizey and small intestine/colon SOMA 0.452 (Po0.001) and Vaizey and rectum SOMA 0.760 (Po0.001). After radiotherapy for a tumour in the pelvis, half of all patients develop gastrointestinal morbidity, which affects their QOL. A modified IBDQ and Vaizey questionnaire are reliable in assessing new gastrointestinal symptoms as well as overall QOL and are much easier to use than LENT SOMA.

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Section: Discussionmentioning

confidence: 86%

A modified Inflammatory Bowel Disease questionnaire and the Vaizey Incontinence questionnaire are simple ways to identify patients with significant gastrointestinal symptoms after pelvic radiotherapy

et al. 2005

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“…Research involving community-based IBD samples has produced mixed conclusions regarding the negative impact of the disease on psychological functioning [22][23][24] . A study that used health records to identify 400 cases, concluded that those with IBD had only minor impairment overall in quality of life domains including general physical symptoms, social functioning, and emotional wellbeing 22 .…”

Section: Introductionmentioning

confidence: 99%

“…A study that used health records to identify 400 cases, concluded that those with IBD had only minor impairment overall in quality of life domains including general physical symptoms, social functioning, and emotional wellbeing 22 . This study found more pronounced difficulties for women and those with…”

Section: Introductionmentioning

confidence: 99%

Stress Coping, Distress, and Health Perceptions in Inflammatory Bowel Disease and Community Controls

Graff

Walker

Clara

et al. 2009

American Journal of Gastroenterology

108

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Psychological health and IBD 2Background: This study compares a community IBD sample with a matched non-IBD community sample on psychological functioning and health perceptions. Methods:Participants in the population-based Manitoba IBD Cohort Study (n=388) were directly compared with sex, age, and region-matched controls from a national random-sample health survey on aspects of psychological health, coping, and perceived general health. Results:The IBD sample overall had lower psychological wellbeing and mastery, and higher distress than the non-IBD controls (p < 0.02). Those with IBD used avoidant coping significantly more often, and active coping modestly more often than the non-IBD sample; both had similar levels of 'self-soothing' behaviors. Crohn's disease and ulcerative colitis participants had similarly poor levels of functioning along these dimensions compared to the non-IBD sample, as did those with active disease (p < 0.01). However, those with inactive disease were similar to the non-IBD sample, and had modestly higher mastery levels. While nearly half of the non-IBD group reported chronic health conditions, those with IBD were threefold more likely to report poorer health (OR 3.07, 95% CI 2.10-4.47). Psychological factors explained a greater amount of variance in perceived health for the IBD than the non-IBD sample. Conclusions:Those with IBD have significantly poorer psychological health than those without IBD and view their general health status more negatively, although adaptive stress coping strategies were similar. However, when disease is quiescent there is little detriment to functioning. Active disease should be a flag to consider psychological needs in the care of the IBD patient.Psychological health and IBD 3

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“…Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) which affects mainly the colon, thus causing abdominal pain, bloody diarrhea and weight loss. Both diseases may cause significant morbidity and diminished life quality [1,2,3,4,5,6]. Treatment options include a variety of anti-inflammatory and immunosuppressant agents.…”

Section: Introductionmentioning

confidence: 99%

Impact of Cannabis Treatment on the Quality of Life, Weight and Clinical Disease Activity in Inflammatory Bowel Disease Patients: A Pilot Prospective Study

2011

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Background and Aims: Inflammatory bowel disease (IBD) patients suffer from significant morbidity and diminished life quality. The plant cannabis is beneficial in various gastrointestinal diseases, stimulating appetite and causing weight gain. Our aims were to assess whether treatment with inhaled cannabis improves quality of life, disease activity and promotes weight gain in these patients. Methods: Patients with long-standing IBD who were prescribed cannabis treatment were included. Two quality of life questionnaires and disease activity indexes were performed, and patient’s body weight was measured before cannabis initiation and after 3 months’ treatment. Results: Thirteen patients were included. After 3 months’ treatment, patients reported improvement in general health perception (p = 0.001), social functioning (p = 0.0002), ability to work (p = 0.0005), physical pain (p = 0.004) and depression (p = 0.007). A schematic scale of health perception showed an improved score from 4.1 ± 1.43 to 7 ± 1.42 (p = 0.0002). Patients had a weight gain of 4.3 ± 2 kg during treatment (range 2–8; p = 0.0002) and an average rise in BMI of 1.4 ± 0.61 (range 0.8–2.7; p = 0.002). The average Harvey-Bradshaw index was reduced from 11.36 ± 3.17 to 5.72 ± 2.68 (p = 0.001). Conclusions: Three months’ treatment with inhaled cannabis improves quality of life measurements, disease activity index, and causes weight gain and rise in BMI in long-standing IBD patients.

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Quality of life in patients with established inflammatory bowel disease: a UK general practice survey

Cited by 83 publications

References 16 publications

A modified Inflammatory Bowel Disease questionnaire and the Vaizey Incontinence questionnaire are simple ways to identify patients with significant gastrointestinal symptoms after pelvic radiotherapy

A modified Inflammatory Bowel Disease questionnaire and the Vaizey Incontinence questionnaire are simple ways to identify patients with significant gastrointestinal symptoms after pelvic radiotherapy

Stress Coping, Distress, and Health Perceptions in Inflammatory Bowel Disease and Community Controls

Impact of Cannabis Treatment on the Quality of Life, Weight and Clinical Disease Activity in Inflammatory Bowel Disease Patients: A Pilot Prospective Study

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