Colorectal cancer is the third leading cause of cancer deaths worldwide with global recent positive trends in colorectal cancer incidence. Between 1990 and 2019, The global agestandardised incidence rate of colorectal cancer increased from 22•2 (95% UI 21•3-23•0) per 100 000 to 26•7 (24•6-28•9) per 100 000. colorectal cancer incident cases more than doubled, from 842 098 (95% uncertainty interval [UI] 810 408-868 574) to 2•17 million (2•00-2•34), and deaths increased from 518 126 (493 682-537 877) to 1•09 million (1•02-1•15). (1) Colorectal cancer survival is highly