Quality of Life in Patients with Advanced Non-Small-Cell Lung Cancer Receiving Palliative Chemotherapy

Daroszewski, Cyryl; Stasiewicz, M.; Jaźwińska−Tarnawska, Ewa; Rachwalik, Anna; Mura, Ewa; Luboch-Kowal, Joanna; Dryś, Andrzej; Bogucki, Zdzisław Artur; Brzecka, Anna

doi:10.1007/5584_2019_346

Cited by 11 publications

(12 citation statements)

References 27 publications

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“…These findings align with previous studies on lung cancer patients, reporting that patients who did not complete chemotherapy had poorer physical functioning at time of diagnosis [ 19 ], and that poor HRQOL might be an indicator of noncompliance with the treatment plan [ 7 ]. In a systematic review, including 104 studies on quality of life and cancer survival, the authors suggested that HRQOL assessed before treatment might provide the most reliable information for assisting clinicians to establish prognostic criteria for treating cancer patients [ 15 ].…”

Section: Discussionsupporting

confidence: 90%

“…A few studies have shown that self-reported HRQOL is associated with planned, as well as actually received, treatment among cancer patients [ 15 , 16 , 17 , 18 ]. Furthermore, a study by Daroszewski et al found that specific domains or parts of HRQOL (decreased physical functioning, loss of appetite, and dysphagia) reported prior to initiation of chemotherapy were associated with not completing the planned treatment among lung cancer patients [ 19 ]. No other studies have, to our knowledge, looked at the association between HRQOL and completion of oncological treatment among lung cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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Association between Health-Related Quality of Life and Completion of First-Line Treatment among Lung Cancer Patients

Levinsen

Dalton

Andersen

et al. 2022

Cancers

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Experts recommend assessing lung cancer patients’ health-related quality of life (HRQOL) in the diagnostic evaluation. We investigated the association between HRQOL and completion of first-line treatment among lung cancer patients in a prospective cohort study. Clinical information on lung cancer patients was obtained from medical records, and information on quality of life and lung cancer-related symptoms was obtained through questionnaires at time of diagnosis. We used directed acyclic graphs to identify potential confounders and mediators between HRQOL and completion of first-line treatment. The association between functioning levels and symptoms and completion of first-line oncological treatment was estimated as odds ratios, with 95% confidence intervals, in logistic regression models. In all, 137 patients (52% men, mean age: 69 years) participated, out of 216 invited. Patients who reported reduced functioning had significantly increased ORs for not completing first-line treatment: poor physical function (OR 4.44), role function (OR 6.09), emotional function (OR 5.86), and social function (OR 3.13). Patients with fatigue (OR 7.55), pain (OR 6.07), appetite loss (OR 4.66), and financial difficulties (OR 17.23) had significantly increased ORs for not completing the first-line treatment. Reduced functioning and presence of symptoms were associated with not completing first-line treatment. An assessment of HRQOL could potentially aid the diagnostic evaluation and treatment planning for lung cancer patients.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Association between Health-Related Quality of Life and Completion of First-Line Treatment among Lung Cancer Patients

Levinsen

Dalton

Andersen

et al. 2022

Cancers

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“…Also, it was observed that there was palliation in the pain symptom in their scores at the beginning and end of RT in patients with lung cancer who underwent concurrent chemoradiotherapy. The pain was reduced in chemotherapy and was found to be in the literature [23]. There was symptom palliation in another randomized trial, similar to our study, especially in cough, hemoptysis, chest pain, and dyspnea in the group that underwent hyperfractionated RT (19).…”

Section: Discussionsupporting

confidence: 87%

The Effect of Thoracic Radiotherapy on the Quality of Life in Lung Cancer Patients

Eren¹,

Eren²,

Koca³

2021

Cureus

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This study aimed to investigate changes in respiratory symptoms and quality of life (QoL) in patients with locally advanced and metastatic lung cancer receiving thoracic radiotherapy (RT). We investigated the correlation between the level of symptom relief and tumor response. Methods Thirty-two patients were included in this study. The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life (QoL) Questionnaire (QLQ)-C30 and EORTC QLQ-LC13 were used to investigate QoL changes. Assessments were performed on the first day of RT, on the last day of RT, routinely monthly follow-ups, and three months after RT. Results The median age of the patients was 62; 88% of the patients were male. For the symptom scale, fatigue and dyspnea provided significant improvement at the end of RT (p=0.000, p=0.047). No significant improvement was observed at the end of RT in pain and insomnia. While coughing showed substantial improvement at the end of RT (p=0.004), the maximum improvement was achieved during the third-month follow-up (p<0.001). No significant improvement was observed at the end of RT in hemoptysis, but a considerable improvement was observed during the third-month follow-up (p=0.008). Conclusion This study confirms that RT offered palliation of respiratory symptoms and improved QoL in a substantial proportion of patients with lung cancer.

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“…Similarly, the negative impact of thoracic cancers such as lung cancer and breast cancer on quality of life is well known and has been studied and described in populations across the world. [6][7][8][9][10] Cancer pain is an important contributing factor to decreased QOL. As pain increases, it starts to interfere with various aspects of daily life, such as appetite, sleep, mood, or basic task such as walking.…”

Section: Indian Journal Of Palliative Carementioning

confidence: 99%

Scrambler Therapy Enhances Quality of Life in Cancer Patients in a Palliative Care Setting: A Randomised Controlled Trial

Kashyap

Singh

Dwivedi

et al. 2022

IJPC

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Objectives: Given the known side effects of opioids and the negative impact of these side effects on quality of life (QOL), there is a need for therapies that can reduce opioid intake and improve QOL in patients suffering from cancer pain. Scrambler therapy (ST) is a neuromodulatory therapy that has been shown to reduce cancer pain, but its effect on QOL is not well understood. This study intended to evaluate the efficacy of ST for enhancing QOL in cancer patients through minimising pain and opioid intake. Material and Methods: This was a randomised controlled trial including 80 patients with head, neck and thoracic cancer. In both arms, patients were given pain management drugs following the WHO analgesic ladder for ten consecutive days. In the intervention arm each day ST was given. Pain, morphine intake, and QOL (WHOQOL-BREF) were assessed. Results: All domains of QOL improved significantly in the intervention arm in comparison to the control arm. In comparison to baseline, pain improved in both the intervention and the control arm on day 10 and at follow-up. However, QOL significantly improved in the intervention arm, while morphine intake decreased. In the control arm, QOL deteriorated, while morphine intake increased. Conclusion: ST significantly improved QOL. Since the increase in QOL took place along with a significantly lower morphine intake, the improvement in QOL may not only be explained by lower pain scores but, also, by a reduced intake of morphine, because the lower dosages of morphine will decrease the likelihood of side effects associated with the drug.

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Quality of Life in Patients with Advanced Non-Small-Cell Lung Cancer Receiving Palliative Chemotherapy

Cited by 11 publications

References 27 publications

Association between Health-Related Quality of Life and Completion of First-Line Treatment among Lung Cancer Patients

Association between Health-Related Quality of Life and Completion of First-Line Treatment among Lung Cancer Patients

The Effect of Thoracic Radiotherapy on the Quality of Life in Lung Cancer Patients

Scrambler Therapy Enhances Quality of Life in Cancer Patients in a Palliative Care Setting: A Randomised Controlled Trial

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