Quality of life in patients with Charcot–Marie–Tooth disease

Abstract

The authors evaluated quality of life in Charcot-Marie-Tooth disease by administering the Medical Outcome Study Short Form-36 (SF-36) questionnaire to 121 Italian patients. Patients scored lower on all of the SF-36 scales compared with Italian normative data. Scores were lower in nonworking vs working patients, women vs men, and older vs younger patients, but not between patients with demyelinating vs axonal forms or between patients who had undergone orthopedic foot surgery vs those who had not.

Pressure characteristics in painful pes cavus feet resulting from Charcot–Marie–Tooth disease

“…Most of the self-report scores fell well short of the values considered ''normal''; in fact, no single participant scored any FHSQ item above 81, and the perceptions of foot health and also availability of suitable footwear were extremely low. Our results for the SF-36 health status components do not differ significantly from those recently reported by Vinci et al [32]. Interestingly, these factors had no discernible association with foot morphology, symptom duration, pain intensity or location of foot pain.…”

Quality of life in patients with Charcot-Marie-Tooth disease type 1A

“…However, this finding must be relativized since, according to another research, the instrument used here may not be able to detect minor changes occurring over short periods in a slowly progressing disease [13][14][15][16] . Evidence highlighting the need for further investigation on this aspect is provided by Vinci et al 17,18 , who observed that age and duration of symptoms are strongly associated with deterioration of quality of life, which did not occur with the subjects investigated in the present study. Cultural and social characteristics of a population are likely to be accountable for these discrepancies 11 , although the small number of patients studied may also have influenced the final results.…”

Long-term results of reconstruction for treatment of a flexible cavovarus foot in Charcot-Marie-Tooth disease

“…The patients had a progressive systemic disease that can result in substantial disability regardless of foot function. A survey of 121 Italian patients with Charcot-MarieTooth disease revealed a mean PCS of 39.3 points 43 , compared with our patients' mean score of 37.6 points. As in our study, the mean PCS for the female Italian patients was lower than that for their male counterparts.…”

“…The demographics of the nonparticipants with regard to age at surgery and percentages of bilateral and unilateral procedures were similar, but there were proportionally more female patients in the study group. Because the female patients tended to have a lower SF-36 PCS both in our study group and in the previously reported literature 43 , the non-participants may actually have had better outcomes than our study group.…”