2021
DOI: 10.1016/j.ejca.2020.11.029
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Quality of life in rectal cancer patients with or without oxaliplatin in the randomised CAO/ARO/AIO-04 phase 3 trial

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Cited by 11 publications
(5 citation statements)
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“…The simulated effectiveness was comparable with values reported in the literature [10][11][12][13][14]49]. Differences occurred from various model's specifications, as we applied specific utilities and transition probabilities from the ARO-04 trial [35,42] for the base case. NOM was dominant over resection in concordance with other cost-effectiveness simulations [10][11][12][13][14]49].…”
Section: Discussionsupporting
confidence: 73%
“…The simulated effectiveness was comparable with values reported in the literature [10][11][12][13][14]49]. Differences occurred from various model's specifications, as we applied specific utilities and transition probabilities from the ARO-04 trial [35,42] for the base case. NOM was dominant over resection in concordance with other cost-effectiveness simulations [10][11][12][13][14]49].…”
Section: Discussionsupporting
confidence: 73%
“…Therefore, the optimal neoadjuvant strategy for LARC patients with clear MRF is still open to future research. Since radiotherapy is associated with radiation toxicities, higher surgical complications, and worse long-term functional outcomes, 15,16 the necessity for radiation in unselected LARC patients is being questioned, especially in those without high-risk factors such as stage cT4b or involved MRF. [17][18][19] Neoadjuvant chemotherapy (nCT) seems a promising alternative.…”
mentioning
confidence: 99%
“…Therefore, the differences in the nerve network between these two anatomical regions might explain the divergencies in QoL among the two groups of patients. Secondly, in our series radiotherapy apparently had a marginal role in improving the QoL of patients with advanced rectal cancer (16)(17)(18). Thirdly, since the improvement of the QoL drives our strategy for treatment, these results might suggest that, whenever it is possible, a surgical approach may be preferable to a stent positioning in advanced rectal cancer.…”
Section: Discussionmentioning
confidence: 72%