A retrospective study was conducted in the Department of Prosthodontics, LUMHS Jamshoro, from January 2022 to January 2023 to assess the effect of removable partial dentures (RPD) on oral health-related quality of life (OHROoL) and masticatory performance (MP) in patients with shortened dental arch. The study was conducted on a total of 19 patients. All included participants received RPD, and OHRQoL and MP were assessed after 2 weeks. The results showed that the MP score improved (177.45 ±38.86) along with OHIP-14 domain scores (4.21 ±4.22) after rehabilitation with RPDs. Hence, RPD effectively improves OHRQoL and MP in patients with mandibular SDA.