Quality of life in Turkish patients with autoimmune blistering diseases: Reliability and validity of the autoimmune bullous disease quality of life and the treatment of autoimmune bullous disease quality of life questionnaires

Bilgic-Temel, Aslı; Irican, Ceren Memiş; Uzun, Soner; Feng, Grant Y.H.; Murrell, Dédée F.; Akman-Karakaş, Ayşe

doi:10.4103/tjd.tjd_16_19

Cited by 3 publications

(7 citation statements)

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“… 14 BP patients generally have a good response rate to treatment meaning lower doses of prednisolone prescription. However, in our study, BP patients had higher TABQOL scores than PV patients, which is in agreement with Turkish, 12 Chinese, 11 and Egyptian 13 studies and in contrast with Polish 7 and Australian 9 studies. This discrepancy is probably due to the difference in the number of BP patients included in each study.…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 77%

“…We did not find any correlation between PDAI and TABQOL score; this finding is similar to Egyptian, 13 Chinese, 11 and Polish 7 studies, while it is in contrast with Turkish 12 study that found a positive correlation between PDAI and TABQOL. We also did not find any correlation between TABQOL and BPDAI scores similar to as Polish 7 and Turkish 12 studies. Although our findings show that QOL is not necessarily related to visible manifestations of the disease, we should consider that the TABQOL questionnaire evaluates the impact of treatment on the QOL rather than the disease itself.…”

Section: Discussionsupporting

confidence: 77%

“…Studies showed that AIBD treatment can impact the quality of life as much as disease itself. 4 , 5 , 7 In this study, TABQOL scores of PV, BP, and all patients were lower than TABQOL scores reported in Australia, 9 China, 11 Poland, 7 Turkey, 12 and Egypt 13 ; while PF patients in our study had higher TABQOL scores than previously reported studies, probably due to cultural differences or treatment approach. Compared with our population, Australian and Turkish 9 , 12 studies demonstrated the highest TABQOL among EBA patients; also, in the Egyptian study, 13 EBA was reported to have the second-highest TABQOL score.…”

Section: Discussioncontrasting

confidence: 76%

“…Moreover, in all previously mentioned studies, 7 , 9 , 11 , 13 there was no significant difference between female and male TABQOL scores. Except for the Turkish study 12 in which women had higher TABQOL scores meaning a worse QOL. However, in our study, the TABQOL scores of women were higher than men; however, the difference was not statistically significant ( P = .052) despite being close to significance.…”

Section: Discussionmentioning

confidence: 86%

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Assessing quality of life in patients with autoimmune bullous diseases using the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life questionnaire finds similar effects in women as men

Behkar

Garmaroudi

Nasimi

et al. 2022

International Journal of Women’s Dermatology

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Background: In autoimmune bullous diseases (AIBDs), autoantibodies loosen molecular adhesions in the skin and/or mucosa and lead to blisters and erosions. Immunosuppressive drugs reduce mortality of the AIBD; therefore, patients will have to live longer with comorbidities. Objective: This study aims to determine the quality of life of AIBD patients undergoing systemic treatment while investigating the survey’s relationship with various factors. Methods: In this 2-step cross-sectional study, we initially included 53 consecutive pemphigus patients to investigate reliability and validity of the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life (TABQOL) questionnaire. Then, we conducted the study on 119 AIBD patients, currently under treatment at an AIBD clinic in Iran. Results: The mean TABQOL score for our patients was 13.87 ± 7.51. The highest TABQOL was for epidermolysis bullosa acquisita (24 ± 8.485) followed by pemphigus foliaceus (20.5 ± 14.181) and the lowest for pemphigus vulgaris (13.24 ± 6.54). There was no significant difference between patients’ TABQOL scores and their gender, history of rituximab injection, and disease severity scores. We only found a positive correlation between TABQOL and prednisolone dose. Conclusion: Treatments of AIBD considerably impact the quality of life of patients and an impairment in quality of life is correlated to higher doses of prednisolone.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 77%

Section: Discussioncontrasting

confidence: 76%

Section: Discussionmentioning

confidence: 86%

See 3 more Smart Citations

Assessing quality of life in patients with autoimmune bullous diseases using the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life questionnaire finds similar effects in women as men

Behkar

Garmaroudi

Nasimi

et al. 2022

International Journal of Women’s Dermatology

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Scoring Criteria for Autoimmune Bullous Diseases: Utility, Merits, and Demerits

Tseng,

Stone,

Murrell

2024

Indian Dermatology Online Journal

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Background: Scoring systems play a crucial role in dermatology by providing objective measurements of disease severity, treatment efficacy, and outcome comparisons. In autoimmune blistering diseases (AIBDs), standardized scoring systems are essential for accurate evaluations; however, there is currently a lack of consensus on scoring methods. Objective: This literature review explores scoring systems in AIBDs by tracing their development, addressing challenges, and highlighting their role in defining endpoints, regulatory considerations, and clinical trials. Materials and Methods: Existing scoring systems for AIBDs, such as the Pemphigus Disease Area Index, Autoimmune Bullous Skin Disorder Intensity Score, Pemphigus Oral Lesions Intensity Score, Oral Disease Severity Score, and Pemphigus Vulgaris Activity Score, are examined for their validity, reliability, and responsiveness. The Bullous Pemphigoid Disease Area Index for bullous pemphigoid is also discussed. The concept of minimal clinically important differences is explored to determine clinically significant improvements in disease severity. Conclusion: This review provides a comprehensive understanding of the central role of scoring systems in dermatology and their implications for research and clinical practice in AIBDs.

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Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal İnvolvement: A Multicenter Observational Study

Kara Polat,

Mülayim,

Falay Gür

et al. 2024

Dermatology Practical &Amp; Conceptual

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Introduction: Pemphigus vulgaris (PV) is an autoimmune disease that mostly affects the oral mucosa. Objectives: This study aimed to determine the demographic, clinical and treatment characteristics as well as the quality of life of patients with PV and oral mucosal involvement. Methods: We conducted a prospective observational study among 106 patients with PV and oral mucosal involvement. Demographic data, clinical and treatment characteristics, and quality of life questionnaires were recorded. Results: Of the 106 patients, 51.89% were males. Mucocutaneous subtype was found in 78.38% of the patients. The initial localization of 41.51% of the patients was only the oral mucosa. Involvement of the bilateral buccal mucosa was observed most frequently in the patients and burning was the most common symptom (85.85%). Oral mucosal examination revealed erosions in 85.85% of the patients. The most frequently used treatment agent in the patients was a systemic steroid, and rituximab used in 16.98% patients. A positive and significant correlation was found between pemphigus severity and OHIP14-TR, DLQI, and DYQS scores (p < 0.05). The quality of life was more significantly adversely affected in those with superficial ulcers, loose bullae, lesion diameter of 1 cm and above, and the number of lesions above 10 in the oral mucosa. Complet response was observed in all patients using rituximab. Conclusions: The most common area of involvement was bilateral buccal mucosa, and the quality of life was affected in correlation with the severity of the disease.

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Quality of life in Turkish patients with autoimmune blistering diseases: Reliability and validity of the autoimmune bullous disease quality of life and the treatment of autoimmune bullous disease quality of life questionnaires

Cited by 3 publications

References 0 publications

Assessing quality of life in patients with autoimmune bullous diseases using the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life questionnaire finds similar effects in women as men

Assessing quality of life in patients with autoimmune bullous diseases using the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life questionnaire finds similar effects in women as men

Scoring Criteria for Autoimmune Bullous Diseases: Utility, Merits, and Demerits

Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal İnvolvement: A Multicenter Observational Study

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