Quality of life in young people with Tourette syndrome: a controlled study

Eddy, Clare M.; Rizzo, Renata; Gulisano, Mariangela; Agodi, Antonella; Barchitta, Martina; Calì, Paola V.; Robertson, Mary M.; Cavanna, Andrea E.

doi:10.1007/s00415-010-5754-6

Cited by 159 publications

(148 citation statements)

References 18 publications

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“…Eddy et al also conducted the only controlled study specifically addressing HR-QOL in GTS to date, comparing the HR-QOL of young people with GTS with that of patients with epilepsy and healthy subjects [44]. In light of the controversy in previous research, these authors further examined whether tic severity or the presence of co-morbidities has a greater bearing on perceived HR-QOL.…”

Section: Studies Of Health Related-quality Of Life In Gilles De La Tomentioning

confidence: 99%

Health-Related Quality of Life in Gilles de la Tourette Syndrome: A Decade of Research

Cavanna

David

Bandera

et al. 2013

Behavioural Neurology

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Abstract. Gilles de la Tourette syndrome (GTS) is a neurodevelopmental condition characterised by multiple motor and phonic tics and associated behavioural problems, carrying a significant burden on patients' lives. Although the term health related-quality of life (HR-QOL) has only been used in recent years, several studies have long addressed the impact of GTS on physical, psychological and social aspects of wellbeing of both children and adults with GTS. We set out to answer the question "Is HR-QOL affected by GTS and, if so, in what domains?" by conducting a systematic literature review of published original studies addressing HR-QOL in both children and adult patients with GTS. This review focuses on the current evidence on the impact of GTS on patients' lives, mainly informed by studies using generic functional impairment and HR-QOL measures from the last decade, and expands on the new opportunities introduced by the recently developed GTS-specific HR-QOL scales (GTS-QOL and GTS-QOL-C&A). Analysis of the first decade of studies specifically addressing HR-QOL in GTS suggests that co-morbid conditions are key factors in determining HR-QOL in young patients, whilst the picture is more complex in adults with GTS. These findings offer some general directions for both current clinical practice and future research. Keywords: Gilles de la Tourette syndrome, health-related quality of life, functional impairment, tics, behavioural problems The functional impact of Gilles de la Tourette syndrome across the lifespanGilles de la Tourette syndrome (GTS) is a life-long neurodevelopmental disorder defined by the presence of multiple motor and phonic tics [1]. Tics are repetitive, uncontrollable movements or vocalizations that usually present in childhood but may change with re- * Corresponding author: Dr. Andrea Eugenio Cavanna, MD, PhD., Department of Neuropsychiatry, The Barberry National Centre for Mental Health, 25 Vincent Drive, Birmingham B15 2FG, UK. Tel.: +44 0121 3012317; Fax: +44 0121 3012291; E-mail: cavanna77@tin.it. gard to their location, frequency and severity over time [2]. GTS affects approximately 1% of school-age youngsters and is three to four times more common in males than females [3]. GTS is increasingly recognised as a complex disorder, with a wide spectrum of associated behavioural problems that can accompany the motor and phonic tics. These problems include ticrelated symptoms (ranging from socially inappropriate statements to actual self-harm) and co-morbid psychiatric disorders, such as obsessive-compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD) [4,5]. Large studies conducted both in clinical populations [2,6] and in the community [7] have consistently found that only about 10% of individuals with GTS do not present with behavioural co-morbidities.

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Section: Studies Of Health Related-quality Of Life In Gilles De La Tomentioning

confidence: 99%

Health-Related Quality of Life in Gilles de la Tourette Syndrome: A Decade of Research

Cavanna

David

Bandera

et al. 2013

Behavioural Neurology

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“…Patients with TS have motor tics which are involuntary rapid and recurrent which can lead to severe ocular trauma [9][10][11]. Tics like head banging, punching and striking of the face or periorbital region can lead to direct coup injury to eye resulting in breakdown of formed vitreous.…”

Section: Discussionmentioning

confidence: 99%

Self Mutilation with Bilateral Rhegmatogenous Retinal Detachment in Tourette’s Syndorme Treated with Pars Plana Vitrectomy

Taneja¹,

Krasniqi²,

Mema³

2017

AOVS

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Gilles de la Tourette's syndrome, is a condition characterized by multiple motor and vocal tics, which appear in childhood and are often accompanied by behavioral symptoms. There are isolated reports which associate this syndrome with color vision deficiencies, self-induced haemophthalmous and dislocation of crystalline lens, retinal detachment and keratoconus. This is a case report of a known case of Gilles de la Tourette's Syndrome patient who presented with bilateral visual loss. The visual loss was as consequence of repeated attacks during which he punched his periorbital region with his hand. There was total rhegmatogenous retinal detachment with advanced proliferative vitreoretinopathy in both eyes. The left eye was treated with phacoemulsification vitrectomy. Retina was successfully attached and remained attached at 1 year follow up after silicone oil removal in the left eye.

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“…Furthermore, these afflicted individuals are socially stigmatized [11,19]. Case studies have indicated that adult patients with GTS, compared with adults in the general population, show more dysfunction in their daily activities and a lower quality of life [20][21][22].…”

Section: ▪ Developmental Trajectory and The Apparent Decrease Of Ticsmentioning

confidence: 99%

Bridging neuroscience and clinical psychology: cognitive behavioral and psychophysiological models in the evaluation and treatment of Gilles de la Tourette syndrome

2013

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SUMMARYCognitive neuroscience and clinical psychology have long been considered to be separate disciplines. However, the phenomenon of brain plasticity in the context of a psychological intervention highlights the mechanisms of brain compensation and requires linking both clinical cognition and cognitive psychophysiology. A quantifiable normalization of brain activity seems to be correlated with an improvement of the tic symptoms after cognitive behavioral therapy in patients with Gilles de la Tourette syndrome (GTS). This article presents broad outlines of the state of the current literature in the field of GTS. We present our clinical research model and methodology for the integration of cognitive neuroscience in the psychological evaluation and treatment of GTS to manage chronic tic symptoms.

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Quality of life in young people with Tourette syndrome: a controlled study

Cited by 159 publications

References 18 publications

Health-Related Quality of Life in Gilles de la Tourette Syndrome: A Decade of Research

Health-Related Quality of Life in Gilles de la Tourette Syndrome: A Decade of Research

Self Mutilation with Bilateral Rhegmatogenous Retinal Detachment in Tourette’s Syndorme Treated with Pars Plana Vitrectomy

Bridging neuroscience and clinical psychology: cognitive behavioral and psychophysiological models in the evaluation and treatment of Gilles de la Tourette syndrome

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