Quality of Life of Chronic Hepatitis C Patients and Its Associated Factors

Cho, Hoo Jeung; Park, Euna

doi:10.24171/j.phrp.2017.8.2.04

Cited by 14 publications

(13 citation statements)

References 16 publications

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“…HCV patients have multiple signs and symptoms of disease, which ranges from the lack of clinical manifestation to the presence of entire body symptoms, which includes loss of appetite and tiredness. At advance stage, abnormal accumulation of fluid in the abdominal cavity occurs other complications include hepatic encephalopathy and jaundice (5). It is not only a hepatic disorder but also a psychosocial disease (6).…”

Section: Introductionmentioning

confidence: 99%

Pharmacoeconomic Considerations and Quality of Life Assessment in Hepatitis C Patients

Sarwar

Aslam

Bashir

et al. 2020

PJPH

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Background: Gradual liver damage occurs due to hepatitis C virus (HCV) that may result in liver fibrosis and even cancer. Pakistan is a developing country with the second highest prevalence 4.5-8% of hepatitis C. The main purpose of this study was to estimate the quality of life of people affected with hepatitis, to create general awareness about the disease and to determine pharmacoeconomic considerations of hepatitis C treatment. Methods: It was a cross-sectional study conducted in village Wali Pur Bura of District Nankana sahib, Punjab, Pakistan. Sample size determined by Daniels equation was 100, both male and female participants were included this study. The data was collected to assess the health status data of study population through validated questionnaire and a urdu version of tool EuroQol 5D-5L, comprising of five (5) questions covering the various aspects of health. Data were analyzed through SPSS version 16. Paired sample statistics for comparing two attributes of the study and frequencies were calculated. Results: In current study, majority (70 %) of patients were belong to the lower class and only 39% patients were aware of Punjab Government's participation in hepatitis free treatment plan. 60% patients showed marked reduction in quality of life and the reason behind was painful interferon therapy. Poor quality of life is observed due to the extra hepatic symptoms of HCV including depression. According to the health scale of 60 participants out of 100 was having below Average health status, 21 participants possessed Average Health while 19 participants had Excellent Health. Conclusion: Hence, concluded that due to hepatitis C, health as well as socioeconomic and family life is badly affected. Majority of the participants were having poor quality of life. Costly treatment is beyond the reach of majority of rural population that increases the incidence of depression among patients and their families.

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Section: Introductionmentioning

confidence: 99%

Pharmacoeconomic Considerations and Quality of Life Assessment in Hepatitis C Patients

Sarwar

Aslam

Bashir

et al. 2020

PJPH

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“…Some Chronic Hepatitis C (CHC) patients deliberate their disease shameful due to the social stigma that hepatitis C infection is assimilated through drug abuse, including narcotics, and risky sexual behaviors. Studies had proposed that these patients are usually concerned about the possibility that they may infect others around them owing to the lack of knowledge on the disease process of Hepatitis C. (13,14) Deficiency of knowledge and awareness about Hepatitis C in the community habitually leads to distortion, missing of opportunities for prevention and treatment, and stigmatization of infected populations. (14) In hepatitis, the presence of the virus in the liver cells causes the immune system to attack the liver, resulting in inflammation and impaired function.…”

Section: Introductionmentioning

confidence: 99%

“…The physical domains include physical functioning (10 items), physical role limitations (4 items), pain (2 items), and general health (6 items). The mental domains comprise vitality (4 items), social functioning (2 items), emotional role limitations (3 items), and mental health (5 items) (13,14) . All items were scored from 1-3, in which ( 3 indicating all of the time, 2 indicating some of the time and 1 indicating none of the time) total generic HRQOL score was obtained by summing the scores of the eight domains.…”

Section: Introductionmentioning

confidence: 99%

Impact of Interactive Digital-Based Hepatitis C Education on Self-Management and Quality of Life of Damanhour University Students Having Hepatitis C.

2019

JHMN

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Background: Chronic hepatitis C virus (HCV) infection is a major public health crisis and currently is the most frequent cause of liver related morbidity and mortality which caused 1.34 million deaths in 2015 globally. Infected individuals experience a variety of physical and psychological symptoms, functional limitations and impaired quality of life as a result of having HCV. Aim of study: is to assess the impact of Interactive Digital-Based Hepatitis C Education on Self-Management and Quality of Life of Damanhour University Students Having Hepatitis C. Hypothesis: University students having Hepatitis C who engage in interactive digital-Based Hepatitis C education demonstrate greater improvement in Self-Management and quality of life than those who are not. Material and Methods: Quasi-experimental pre/post-test research design. Settings: The study was carried out in the medical health insurance clinic affiliated to Damanhour University. Subjects: the total sample was 36 students having Hepatitis C. Tools: Data was collected through using students' knowledge about HCV Structured Questionnaire Sheet, Generic health-Related Quality Of Life Scale, Disease-Specific Health-Related Quality Of Life questionnaire, Hepatitis C Self-Management Profile Scale and Satisfaction with Interactive Digital-Based Hepatitis C educational program scale. Results: More than half of the intervention group (55.6%) aged more than 20 years with a mean age of 20.9±2.01 years, and more than one third of the control group (38.9%) with a mean age of 19.4±2.17 years. Above two thirds of the intervention and control groups, (66.7%, and 50.0% respectively) were males. Social networks and Websites, reported as the main source of information about hepatitis C by less than half of the intervention group (44.4%), and more than two thirds of the control group (66.7%). Only 11.1% of the intervention group had good knowledge level at pre program, with mean score of 7.08±3.01 compared to less than two thirds of them (61.1%) in post program. Significant differences was observed between intervention group at pre and 3 months post program implementation (t1=4.25, P=0.002). Interactive Digital-Based Education showed a significant impact on the intervention group's practices in different areas of Hepatitis C self-management. It is evident that, statistical significant correlation was found between intervention group's satisfaction with the program and total score of self-management practices and quality of life in post program. Conclusion and Recommendations: Interactive Digital-Based Education on Self-Management of Hepatitis C had positive impact on HCV outcomes including improvement in Hepatitis C knowledge, self-management practices and quality of life. In addition, it plays a significant role in improving Hepatitis C control, and motivates the students to adopt healthy lifestyle. The overall results revealed that, university students' satisfaction with Interactive Digital-Based Hepatitis C educational program was high. Therefore, use interactive technolog...

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“…Patients infected with HCV present with a compromised HRQOL [ 8 – 10 ] and WP, with deteriorating rates of both absenteeism and presenteeism [ 11 ]. Treatment with interferon (IFN) is available to these patients but has been associated with limited therapeutic success rates and a high presence of side effects, including depression and fatigue [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment with Sofosbuvir and Daclatasvir (with or without Ribavirin) Improves Patient Reported Outcomes in Hepatitis C

Medeiros

Lima

Pires

et al. 2018

Osong Public Health Res Perspect

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ObjectivesTo evaluate the impact of 3 treatment regimens upon health-related quality of life and work productivity using patient-reported outcomes (PROs) in chronic hepatitis C infected patients: sofosbuvir (SOF) + daclatasvir (DCV); SOF + DCV + ribavirin (RBV); SOF + simeprevir (SMV).Methods4 questionnaires were used to evaluate PROs before, during and after treatment: Short Form-36 (SF-36), Chronic Liver Disease Questionnaire (CLDQ) - hepatitis C virus (HCV), Work Productivity and Activity Index, Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F).ResultsOf the global sample of 55 patients included in this study; SOF + DCV (n = 10); SOF + DCV + RBV (n = 29); SOF + SMV (n = 16) all had a statistically significant improvement in SF-36, CLDQ and FACIT-F scores during and post-treatment. No statistically significant differences in the PRO questionnaire values were observed between the distinct treatment regimens. The SOF and SMV patient groups presented higher mean PRO variations during and post-treatment, compared to the other groups: SF-36 functional capacity (16.1); SF-36 mental health (21.4); CLDQ activity (1.8); CLDQ emotional function (1.2); FACIT-F physical well-being (8.0); Total FACIT-F (21.6).ConclusionTreatment with SOF + DCV, with or without RBV, results in an improved PRO similar to treatment with SOF + SMV in chronic hepatitis C patients.

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Quality of Life of Chronic Hepatitis C Patients and Its Associated Factors

Cited by 14 publications

References 16 publications

Pharmacoeconomic Considerations and Quality of Life Assessment in Hepatitis C Patients

Pharmacoeconomic Considerations and Quality of Life Assessment in Hepatitis C Patients

Impact of Interactive Digital-Based Hepatitis C Education on Self-Management and Quality of Life of Damanhour University Students Having Hepatitis C.

Treatment with Sofosbuvir and Daclatasvir (with or without Ribavirin) Improves Patient Reported Outcomes in Hepatitis C

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