Quality Of Life Of Diarrheal Children And Caregivers In Thailand

Abstract

objeCtives: Liver transplantation is an effective treatment option for end-stage liver disease and acute liver failure, including patients with hepatitis C (HCV) and hepatitis B (HBV). Recent health technology assessments of treatments for HCV and HBV have relied on data from a large cohort study of transplanted patients to inform estimates of costs of liver tranplantations; however this was conducted in the 1990s. The overall aim of this study was to estimate the current cost of liver transplant for patients with HCV and HBV in the UK. Methods: Historical summary data from the original cohort study were updated to reflect current unit costs and key changes in clinical practice. Semi-structured interviews were conducted with experts and a computer-based user-interface was developed to elicit estimates of key resource use items. Uncertainty in the experts' estimates was captured by eliciting probability distributions for each item from each expert. Updated unit costs were obtained from national sources. Data were analysed by phase of the transplant procedure. Results: The expert elicitation exercise included two hepatologists, three transplant surgeons and one liver transplant coordinator. Few patients with HBV are now being transplanted due to improvements in anti-viral treatments. Mean total costs for patients with HCV were £18,055 pre-transplantation, £64,452 during the transplant phase and £36,009 in two years post-transplant. The average cost per transplanted patient with HCV from assessment to two years post-transplant is £111,810. ConClusions: There have been some significant changes in clinical practice since the original study such as change in standard immunosuppressant therapy, more patients with co-morbidities being placed on the transplant waiting list, increased use of sub-optimal organs and reluctance to re-transplant patients with graft failure and recurrence of HCV.objeCtives: The impact of liver diseases (LDs) on health-related quality of life (HRQoL) is an important aspect to understand the burden of these conditions and improve their management. A well characterized impact of the major LDs

Quality of life impacts from rotavirus gastroenteritis on children and their families in the UK

“…Both used the EQ5D for both parent and child (despite there being no validated value sets for children). The first study from Thailand [25] examined hospitalised children and rated the mean child's utility as 0.604 (95%CI: 0.592, 0.615) and parents of 0.618 (95%CI: 0.606, 0.629). The second study from Denmark [26] of all gastroenteritis attendances found median HRQoL of 0.7123 for children, and 0.818 for parents with a median length of illness of 7 days.…”

Rotavirus infection

“…In addition, few studies have used multiple assessments to measure the effect of an acute illness on QOL for the entire episode, as most studies assess HRQOL only at presentation to a health-care facility. The limited number of studies assessing the association between rotavirus illness and QOL from Europe, North America and Thailand have estimated HRQOL to range from 0.604 to 0.896 in children and 0.618 to 0.875 in parents, where 1 indicates no effect of illness 169,170 . The differences between locations might be due to variations in the tools used, the type of health-care facility available and cultural determinants regarding when children are taken to a health-care facility.…”