Quality of life of early-stage breast cancer patients treated with radical mastectomy or breast-conserving procedures: results of EORTC trial 10801

Curran, Desmond; Dongen, J van; Aaronson, Neil K.; Kiebert, G.M.; Fentiman, IS; Mignolet, F; Bartelink, Harry

doi:10.1016/s0959-8049(97)00312-2

Cited by 312 publications

(211 citation statements)

References 25 publications

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“…The selection of age, tumor size, axillary surgery, and adjuvant chemotherapy as sociodemographic and oncological impact factors on the QoL of breast cancer patients is based on clinical studies [1][2][3][4][5][6][7][8][9]. The impact of primary surgical treatment (BCT vs mastectomy), especially in relation to long-term body image, would also have been of interest [3,5], but the very small subgroup of patients treated with mastectomy (8%) did not allow statistical analysis.…”

Section: Limitations Of the Studymentioning

confidence: 99%

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Personality traits and psychosocial stress: quality of life over 2 years following breast cancer diagnosis and psychological impact factors

Engel²,

et al. 2009

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Objective: The aim of this study was to investigate changes in the quality of life (QoL) and body image among breast cancer patients over 2 years and to examine different predictive factors for QoL 2 years after the primary operation.Methods: A total of 203 women with a primary diagnosis of breast cancer completed the questionnaires 2 weeks and 6, 12, 18, and 24 months after surgery. Quality of Life Questionnaire (QLQ-C30), Breast Cancer Specific Quality of Life Questionnaire Module (QLQ-BR23), Questionnaire on Stress in Cancer Patients (QSC-R23), Freiburg Personality Inventory (FPI-R), Life Orientation Test (LOT) were used as standardized measures.Results: The overall QoL and most functional and symptom scales improved during the 2-year period. However, cognitive functioning, body image, and the three symptom scales of insomnia, constipation, and diarrhea did not change. Age was only capable of predicting physical functioning, whereas tumor size, axillary surgery, and adjuvant chemotherapy were not predictive of the long-term QoL functional scores. Initial distress was the most potent predictive factor for long-term QoL. Baseline functioning predicted functional QoL scores 2 years later. And higher scores for neuroticism were associated with a poorer QoL. However, optimism was not capable of predicting the QoL 2 years later.Conclusion: Screening measures should be implemented at the time when breast cancer is diagnosed, in order to identify psychologically vulnerable patients and offer them professional psycho-oncological help.

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Section: Limitations Of the Studymentioning

confidence: 99%

“…Most studies have focused on clinical factors affecting QoL in breast cancer patients, such as the type of surgery, adjuvant treatment, clinical tumor size, number of positive axillary nodes, and comorbidity [1][2][3][4][5]. Age has been examined as a possible sociodemographic impact factor affecting QoL [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Personality traits and psychosocial stress: quality of life over 2 years following breast cancer diagnosis and psychological impact factors

Engel²,

et al. 2009

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“…2,3 For some 20 years, cancer surgery has improved with glandular modelling techniques borrowed from plastic surgery to reduce the consequence of radical breast surgery. It is now proven that breast reconstruction has a favourable incidence on quality of life, regardless of the technique used.…”

Section: Recherchementioning

confidence: 99%

“…It is now proven that breast reconstruction has a favourable incidence on quality of life, regardless of the technique used. 2,4 The surgical treatment of breast cancer presently includes as a matter of course the partial or total repair of the amputated breast. These surgical techniques have improved constantly since their inception.…”

Section: Recherchementioning

confidence: 99%

Mammoplasty for symmetry in breast reconstruction and histologic assessment

Horo

Acker²,

Roussel³

et al. 2011

Can J Surg

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Background:In breast reconstruction, complementary surgery on the contralateral breast is sometimes necessary to obtain a satisfactory aesthetic result. This complementary mammoplasty for symmetry gives the surgeon the opportunity to verify the state of the mammary glandular tissue to rule out a possible occult tumour in the contralateral breast. Our objective was to determine the prevalence of borderline lesions and of in situ and invasive carcinoma in specimens of the contralateral breast in a mammoplasty for symmetry in patients with breast cancer. Methods:We conducted a retrospective study of 145 breast reconstructions with mammoplasty for symmetry conducted at the Tours Regional Teaching Hospital in France. Results:The glandular histologic result after mammoplasty was normal in 45.5% of patients, with benign pathologies in 38.9% and borderline lesions in 15.6% of patients. No invasive or in situ carcinoma was detected. Conclusion:Systematic histologic analysis of glandular mammary tissue sampled after reduction mammoplasty in the particular context of breast reconstruction after breast cancer makes it possible to discover lesions that were not seen in presurgical evaluation. The early management of these borderline occult lesions could reduce the incidence of breast cancer in these at-risk patients.Contexte : Les reconstructions mammaires nécessitent parfois un geste complémen-taire sur le sein controlatéral pour un résultat esthétique satisfaisant. Cette chirurgie de symétrisation a l'avantage de donner l'opportunité au chirurgien d'analyser l'état du tissu glandulaire pour éliminer une éventuelle tumeur controlatérale occulte. Notre but était de déterminer la prévalence des lésions frontières, des cancers in situ et invasifs dans les spécimens de plasties mammaires de symétrisation chez les patientes atteintes de cancer du sein.Méthodes : Nous avons étudié rétrospectivement 145 reconstructions mammaires avec une plastie mammaire de symétrisation réalisée au centre hospitalier régional et universitaire de Tours.

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“…Breast conservation surgery, combined with radiotherapy, chemotherapy, and hormonal therapy, is performed with increasing frequency in patients with early-stage breast cancer. The more from the mastectomy toward breast conservation therapy has not changed long-term survival rates of patients with breast cancer (Veronesi et al, 1993;Fisher et al, 1995;Jacobson et al, 1995;Curran et al, 1998).…”

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confidence: 99%

A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer

et al. 2003

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High-intensity focused ultrasound (HIFU) is a noninvasive treatment that induces complete coagulative necrosis of a tumour at depth through the intact skin. This study was to explore the possibility of using HIFU for the treatment of patients with localised breast cancer in a controlled clinical trial. A total of 48 women with biopsy-proven breast cancer (T 1 -2 , N 0 -2 , M 0 ) were randomised to the control group in which modified radical mastectomy was performed, and the HIFU group in which an extracorporeal HIFU ablation of breast cancer was followed by modified radical mastectomy. Short-term follow-up, pathologic and immunohistochemical stains were performed to assess the therapeutic effects on tumour and complications of HIFU. The results showed that no severe side effect was observed in the HIFU-treated patients. Pathologic findings revealed that HIFU-treated tumour cells underwent complete coagulative necrosis, and tumour vascular vessels were severely damaged. Immunohistochemical staining showed that no expression of PCNA, MMP-9, and CD44v6 was detected within the treated tumour cells in the HIFU group, indicating that the treated tumour cells lost the abilities of proliferation, invasion, and metastasis. It is concluded that, as a noninvasive therapy, HIFU could be effective, safe, and feasible in the extracorporeal treatment of localised breast cancer.

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Quality of life of early-stage breast cancer patients treated with radical mastectomy or breast-conserving procedures: results of EORTC trial 10801

Cited by 312 publications

References 25 publications

Personality traits and psychosocial stress: quality of life over 2 years following breast cancer diagnosis and psychological impact factors

Personality traits and psychosocial stress: quality of life over 2 years following breast cancer diagnosis and psychological impact factors

Mammoplasty for symmetry in breast reconstruction and histologic assessment

A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer

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