Purpose : This study aimed to identify factors influencing the quality of life of family caregivers of intensive care unit (ICU) patients.Methods : We conducted a study using a cross-sectional design. The study involved 109 family caregivers of ICU patients at a university-affiliated hospital in Gyeonggi-do, South Korea. Data were collected through self-report questionnaires between July 2020 and April 2021 and analyzed using descriptive statistics, independent t-tests, one-way ANOVA, Pearson’s correlation coefficients, and multiple regression analysis.Results : The study revealed significant differences in quality of life based on economic status (F=11.63, p < .001), cohabitation with patients (t=-2.04, p=.044), sleep duration after patient’s admission to the ICU (t=-2.48, p =.025), and subjective health status (F=30.06, p <.001). There were significant negative correlations observed between quality of life and post-traumatic stress symptoms (r=-.38, p <.001) as well as caregiver burden (r=-.46, p <.001). Factors affecting quality of life were subjective health status, economic status, and caregiver burden (adj. R2 =0.52, F=15.64, p <.001).Conclusion : These findings underscore the need to develop and implement intervention programs tailored to the health conditions and economic status of family caregivers, with a focus on alleviating caregiver burden. Such initiatives are essential to ultimately improve the quality of life for family caregivers of ICU patients.