The study aimed to evaluate the knowledge and health-related quality of life (HRQoL) of young women with polycystic ovarian syndrome (PCOS) in Jolo during the Fiscal Year 2023. The study involved 33 respondents, mostly single with college level, aged between 20 and 30 years, and with a menstrual cycle of once in 9-12 months with 2-7 days of menstrual period. The findings showed that on average, respondents agreed that there was a high extent of knowledge about PCOS and a high quality of life. However, variables such as age, civil status, educational level, frequency of menstruation, and length of menstruation did not significantly mediate the assessment of knowledge and health-related quality of life. This study support the theory of Adaptation Model of Nursing that has been promulgated by Sister Callista Roy in 1976. Roy explained that adaptation occurs when people respond positively to environmental changes, and it is the process and outcome of individuals and groups who use conscious awareness, self-reflection, and choice to create human and environmental integration. The key concepts of Roy’s Adaptation Model are made up of four components: person, health, environment, and nursing (Kozier, 2020).