Quality of life of oropharyngeal cancer patients with respect to treatment strategy and p16‐positivity

Broglie, Martina A.; Soltermann, Alex; Haile, Sarah R.; Röösli, Christof; Huber, Gerhard; Schmid, Stephan; Stoeckli, Sandro J.

doi:10.1002/lary.23622

Cited by 62 publications

(57 citation statements)

References 57 publications

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“…53 Minimizing and focusing XRT, while avoiding chemotherapy lead to less treatment toxicity and improved outcomes. 53–55 Patients with early stage disease treated with surgery alone, demonstrate superior outcomes by avoiding the toxicity of XRT. 27,54,56 Although this data is still in its infancy, TORS is showing promise as an optimal treatment strategy in early stage disease.…”

Section: Commentmentioning

confidence: 99%

Transoral Robotic Surgery for Oropharyngeal Cancer

Dziegielewski

Teknos

Durmuş

et al. 2013

JAMA Otolaryngol Head Neck Surg

197

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Objective To determine swallowing, speech and quality of life (QOL) outcomes following transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC). Design Prospective cohort study. Setting Tertiary care academic comprehensive cancer center. Patients 81 patients with previously untreated OPSCC. Intervention Primary surgical resection via TORS and neck dissection as indicated. Main Outcome Measures Patients were asked to complete the Head and Neck Cancer Inventory (HNCI) pre-operatively and at 3 weeks as well as 3, 6 and 12 months post-operatively. Swallowing ability was assessed by independence from a gastrostomy tube (G-Tube). Clinicopathological and follow-up data were also collected. Results Mean follow-up time was 22.7 months. HNCI response rates at 3 weeks and 3, 6, and 12 months were 79%, 60%, 63%, 67% respectively. There were overall declines in speech, eating, aesthetic, social and overall QOL domains in the early post-operative periods. However, at 1 year post-TORS scores for aesthetic, social and overall QOL remained high. Radiation therapy was negatively correlated with multiple QOL domains (p<0.05), while age > 55 years correlated with lower speech and aesthetic scores (p<0.05). HPV status did not correlate with any QOL domain. G-Tube rates at 6 and 12 months were 24% and 9%, respectively. The extent of TORS (> 1 oropharyngeal site resected) and age > 55 years predicted the need for a G-Tube at any point after TORS (p<0.05). Conclusions Patients with OPSCC treated with TORS maintain a high QOL at 1 year after surgery. Adjuvant treatment and advanced age tend to decrease QOL.

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Section: Commentmentioning

confidence: 99%

Transoral Robotic Surgery for Oropharyngeal Cancer

Dziegielewski

Teknos

Durmuş

et al. 2013

JAMA Otolaryngol Head Neck Surg

197

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“…Management decisions must be based on the likelihood of cure as well as the resulting structural, cosmetic, and functional deficits, which can negatively impact quality of life (QoL) [1,2].…”

Section: Introductionmentioning

confidence: 99%

A systematic review of quality of life in head and neck cancer treated with surgery with or without adjuvant treatment

et al. 2015

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“…13 Radiation therapy as a negative factor in quality of life measures has been found in other studies as well. Broglie et al 66 found that both IMRT and surgery provide better measures than conventional radiation, and Leonhardt et al 67 reported that patients receiving TORSonly procedures had improved functional status compared with patients receiving TORS combined with adjuvant therapy. Transoral robotic surgery may therefore be used to enhance quality of life by decreasing long-term functional sequelae associated with radiation.…”

mentioning

confidence: 99%

Transoral Robotic Surgery in Oropharyngeal Carcinoma

Helman¹,

Schwedhelm²,

Kadakia³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context The incidence of oropharyngeal squamous cell carcinoma has increased during the past decade and is related primarily to the human papillomavirus. This change in etiology, from tobacco and alcohol to human papillomavirus, has resulted in improved survival for the disease. In the United States, open resection had largely been replaced by concurrent chemotherapy and/or radiotherapy by the early 2000s. The advent of transoral surgery has led to an increase in surgery as the primary treatment for both early- and advanced-stage oropharyngeal squamous cell carcinoma because it has potential advantages over open surgery and nonsurgical modalities. Objective To provide an overview of transoral robotic surgery for oropharyngeal squamous cell carcinoma and contrast it with other surgical and nonsurgical modalities. Data Sources Articles from 2000 to 2014 were accessioned on PubMed and reviewed for utility by the primary authors. Conclusions Transoral surgery has become more commonly used as a minimally invasive approach to treat oropharyngeal tumors. Other strategies, including radiation, chemotherapy with radiation, and open surgery, are still important treatment approaches. The treatment options for an individual patient rely on multiple factors, including the tumor location and size, features of the tumor, and patient comorbidities. The continued study of these techniques is important to match the patient with the most appropriate treatment.

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Quality of life of oropharyngeal cancer patients with respect to treatment strategy and p16‐positivity

Cited by 62 publications

References 57 publications

Transoral Robotic Surgery for Oropharyngeal Cancer

Transoral Robotic Surgery for Oropharyngeal Cancer

A systematic review of quality of life in head and neck cancer treated with surgery with or without adjuvant treatment

Transoral Robotic Surgery in Oropharyngeal Carcinoma

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