Quality of Life of Patients with Unruptured Intracranial Aneurysms Before and After Endovascular Coiling: A HEAT Trial Secondary Study and Systematic Review of the Literature

Abi-Aad, Karl R.; Rahme, Rudy J.; Syal, Arjun; Patra, Devi P; Hudson, Miles; Richter, Kent R.; Ward, Jennifer; Knis, Jason; Nak, Yak; Turcotte, Evelyn L.; Welz, Matthew E.; Winter, Jo Dee; Krishna, Chandan; Chong, Brian W.; Bendok, Bernard R.

doi:10.1016/j.wneu.2020.10.120

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…A study performed by Zhai et al [ 21 ] revealed that patients with UIA undergoing endovascular treatment had a decreased health-related quality of life (HRQoL) when compared to the general population. Conversely, the HEAT trial secondary study on HRQoL after endovascular coiling of UIA revealed that a subset of patients had improvements in some physical and emotional components of QoL after treatment [ 1 ]. While data is scarce regarding microsurgical clipping and HRQoL, Solheim et al [ 19 ] showed that microsurgical clipping and endovascular coiling did not differ on their impact on patients’ HRQoL when undergoing treatment for UIA.…”

Section: Discussionmentioning

confidence: 99%

Microsurgical clipping vs Woven EndoBridge (WEB) device for the management of unruptured wide-neck bifurcation aneurysms

2022

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The Woven EndoBridge device (WEB) was introduced in 2010 to treat wide-neck bifurcation aneurysms (WNBAs). Three landmark studies have been conducted to assess its safety and efficacy: WEBCAST, WEBCAST 2, and French Observatory Study. However, these studies have not compared its safety and efficacy to other treatment modalities. In this study, we compare WEB versus microsurgical clipping in the management of unruptured WNBA. We conducted a retrospective study of unruptured WNBA meeting the morphological criteria to be amenable for WEB treatment operated on at our institution. Surgical morbidity, mortality, and occlusion rates were assessed. We compared our results to those reported in the cumulative population of the three WEB landmark studies at 1 year. A total of 84 patients with 89 WNBA were included. The most common aneurysm location was the middle cerebral artery bifurcation (n = 67/89, 75%). No operative mortality was observed. Morbidity comprised small-vessel vasospasm (n = 1/89, 1%) resulting in hemiparesis vs. 3% morbidity for WEB (p = .324). All but one (n = 1/89, 1%) WNBA were completely occluded vs WEB occlusion rate of 53% at 1 year, statistically significantly worse (p < .001). In our analysis, we were not able to show superiority of WEB in terms of procedural morbidity in comparison to microsurgical clipping, defined as worsening in mRS. Microsurgical clipping achieves statistically significantly higher rates of complete aneurysm occlusion, thus posing the question of whether the WEB should be presented as a viable, comparable alternative to patients amenable to surgical treatment.

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Section: Discussionmentioning

confidence: 99%

Microsurgical clipping vs Woven EndoBridge (WEB) device for the management of unruptured wide-neck bifurcation aneurysms

2022

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“…Approximately 2-4% of the population harbours an unruptured intracranial aneurysm [16][17][18][19][20][21] , and up to 30% and 42% of these patients may have multiple aneurysms in imaging or autopsy studies, respectively. [22][23] With increased utilization of noninvasive imaging, the detection of these aneurysms has become very common, the so-called incidentaloma.…”

Section: Introductionmentioning

confidence: 99%

Incidental intracranial saccular aneurysm in a patient with post-Covid-19 headache: What to do with the incidentaloma?

Valênça

Silva

Mendes

et al. 2021

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Impact of Illness Uncertainty on Health-Related Quality of Life in Patients With Unruptured Intracranial Aneurysms After Coil Embolization

Lee,

Lee

2024

Journal of Neuroscience Nursing

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BACKGROUND: This study aimed to identify the impact of illness uncertainty on physical and mental health-related quality of life (HRQoL) in patients with unruptured intracranial aneurysms (UIAs) after coil embolization. METHODS: A cross-sectional study was conducted and HRQoL was evaluated using the Short Form-12 Health Survey Questionnaire, which assesses physical and mental HRQoL. RESULTS: The participants had a mean age of 56.4 years, and among them, 190 (71.2%) were women. Physical and mental HRQoL were negatively correlated with physical symptoms, anxiety, depression, and illness uncertainty. Mental HRQoL was positively correlated with social support. Physical HRQoL was significantly influenced by depression (β = −0.26, P = .004) and was not influenced by illness uncertainty (β = −0.10, P = .101). Mental HRQoL was significantly influenced by anxiety (β = −0.45, P < .001), depression (β = −0.19, P = .003), social support (β = 0.14, P = .004), and illness uncertainty (β = −0.14, P = .005). The finding that illness uncertainty influences HRQoL suggests a basis for interventions aimed at improving mental HRQoL by reducing illness uncertainty in patients with UIAs. CONCLUSION: The physical and mental HRQoL in patients with UIAs after coil embolization is negatively influenced by depression, whereas mental HRQoL is also affected by anxiety, illness uncertainty, and social support. These results may serve as reference data for the design and development of interventions to improve HRQoL in patients with UIAs after coil embolization.

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Quality of Life of Patients with Unruptured Intracranial Aneurysms Before and After Endovascular Coiling: A HEAT Trial Secondary Study and Systematic Review of the Literature

Cited by 3 publications

References 21 publications

Microsurgical clipping vs Woven EndoBridge (WEB) device for the management of unruptured wide-neck bifurcation aneurysms

Microsurgical clipping vs Woven EndoBridge (WEB) device for the management of unruptured wide-neck bifurcation aneurysms

Incidental intracranial saccular aneurysm in a patient with post-Covid-19 headache: What to do with the incidentaloma?

Impact of Illness Uncertainty on Health-Related Quality of Life in Patients With Unruptured Intracranial Aneurysms After Coil Embolization

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