Quality of Life of Patients Undergoing Surgical Treatment for Newly-Diagnosed, Clinically Localized Renal Cell Carcinoma

Ames, Steven C.; Parker, Alex S.; Crook, Julia E.; Diehl, Nancy N.; Tan, Winston; Williams, Christopher R.; Ames, Gretchen E.

doi:10.1080/07347332.2011.616574

Cited by 16 publications

(17 citation statements)

References 22 publications

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“…With this in mind, a logical interpretation of our results is that the QoL metrics that are important for patients with RCC, and those that could be modulated by the type of surgery are not disease specific. Further supporting this notion is our own previous observation that RCC patients do not express a high level of concern regarding their cancer following surgical excision of the tumor [4]. Indeed, attitudes expressed in the focus groups for our previous study indicated a low level of concern regarding the risk of cancer recurrence following surgery.…”

Section: Discussionsupporting

confidence: 58%

“…To date, a handful of investigators have addressed the question of QoL outcomes in RCC patients [4][5][6][7][8][9][10]; however only three have directly addressed the direct comparison of QoL measures between patients undergoing NSS and RN [5,6,8]. Interestingly, while one study reported no difference in QoL-related outcomes between the two surgical groups [5], two of the studies presented evidence suggesting improved QoL outcomes for the NSS versus RN group [6,8].…”

Section: Introductionmentioning

confidence: 93%

“…Finally, we did not use a validated survey for measuring RCC-specific QoL because there are currently no validated tools for measuring RCCspecific QoL. We attempt to address this disparity by utilizing a modified, renal specific version of the FACT-G that included questions derived from our previously published focus group of RCC patients [4]. The benefits of this approach aside, future investigations of RCC-related QoL can and should address this need for a validated measure as this will be of great importance in an era where issues of survivorship have moved closer to the forefront of research efforts.…”

Section: Discussionmentioning

confidence: 99%

“…The questionnaire measures four specific QoL domains (physical, social, emotional, and functional well-being) which each have individual scores but are also summed to achieve a total score, with higher scores indicating better QoL. For this study, we used our experience from a previously published focus group of surgically-treated RCC patients to augment the FACT-G with eight additional questions designed to address kidney-specific QoL issues [4]. Each question presents a statement and the patient indicates whether this occurs "Not at All", "A Little Bit", "Somewhat", "Quite a Bit" or "Very Much".…”

Section: Quality Of Life Measuresmentioning

confidence: 99%

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825 Comparison of Baseline Quality of Life Measures Between Renal Cell Carcinoma Patients Undergoing Partial Versus Radical Nephrectomy

et al. 2010

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Background: To compare demographics, pathologic features, performance scores, comorbidities, symptoms and responses to quality of life (QoL) surveys between nephron-sparing surgery (NSS) and radical nephrectomy (RN) patients prior to surgical intervention. Previous investigators have compared QoL outcomes for patients undergoing RN and NSS; however, there are limited data comparing QoL-related characteristics at baseline between these groups. Methods: We identified 144 patients with localized RCC who underwent either NSS (n = 71) or RN (n = 73) between May '07-November '12. We abstracted baseline data on demographic and clinic-pathologic variables as well as responses to the SF-36 and FACT-G surveys from our prospective registry. We amended the FACT-G with 8 additional questions designed to address RCC-specific QoL. For comparisons between the two groups, we employed Wilcoxon rank-sum and Fisher's Exact tests where appropriate. Results: We observed RN patients to have more aggressive pathology. We noted no difference in performance scores between the two groups; however, RN patients were more likely to have higher Charlson scores (p = 0.022) and various symptoms at presentation (all p <0.001). For the QoL surveys, we did not observe differences on the FACT-G; however, we noted evidence of differential scores between the two groups on specific domains of the SF-36 (e.g. Mental Health; p 0.022) and the RCC-specific QoL questions added to the FACT-G. Conclusions: We report baseline differences between RN and NSS patients on clinico-pathologic as well as QoL-related metrics. As issues of survivorship become increasingly important, our results underscore the need to consider baseline status in evaluations of QoL-related outcomes for patients undergoing surgery for RCC.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Quality Of Life Measuresmentioning

confidence: 99%

See 2 more Smart Citations

825 Comparison of Baseline Quality of Life Measures Between Renal Cell Carcinoma Patients Undergoing Partial Versus Radical Nephrectomy

et al. 2010

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show abstract

“…To date, a handful of investigators have addressed the question of QoL outcomes in RCC patients [4-10]; however only three have directly addressed the direct comparison of QoL measures between patients undergoing NSS and RN [5,6,8]. Interestingly, while one study reported no difference in QoL-related outcomes between the two surgical groups [5], two of the studies presented evidence suggesting improved QoL outcomes for the NSS versus RN group [6,8].…”

Section: Introductionmentioning

confidence: 99%

Comparison of baseline quality of life measures between renal cell carcinoma patients undergoing partial versus radical nephrectomy

Arnold¹,

Thiel

Diehl³

et al. 2013

BMC Urol

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BackgroundTo compare demographics, pathologic features, performance scores, comorbidities, symptoms and responses to quality of life (QoL) surveys between nephron-sparing surgery (NSS) and radical nephrectomy (RN) patients prior to surgical intervention. Previous investigators have compared QoL outcomes for patients undergoing RN and NSS; however, there are limited data comparing QoL-related characteristics at baseline between these groups.MethodsWe identified 144 patients with localized RCC who underwent either NSS (n = 71) or RN (n = 73) between May ‘07-November ‘12. We abstracted baseline data on demographic and clinic-pathologic variables as well as responses to the SF-36 and FACT-G surveys from our prospective registry. We amended the FACT-G with 8 additional questions designed to address RCC-specific QoL. For comparisons between the two groups, we employed Wilcoxon rank-sum and Fisher's Exact tests where appropriate.ResultsWe observed RN patients to have more aggressive pathology. We noted no difference in performance scores between the two groups; however, RN patients were more likely to have higher Charlson scores (p = 0.022) and various symptoms at presentation (all p <0.001). For the QoL surveys, we did not observe differences on the FACT-G; however, we noted evidence of differential scores between the two groups on specific domains of the SF-36 (e.g. Mental Health; p 0.022) and the RCC-specific QoL questions added to the FACT-G.ConclusionsWe report baseline differences between RN and NSS patients on clinico-pathologic as well as QoL-related metrics. As issues of survivorship become increasingly important, our results underscore the need to consider baseline status in evaluations of QoL-related outcomes for patients undergoing surgery for RCC.

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Psychoonkologische Aspekte urologischer Tumorerkrankungen

Berberich¹,

Buntrock²,

Dräger

2022

Die Urologie

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Quality of Life of Patients Undergoing Surgical Treatment for Newly-Diagnosed, Clinically Localized Renal Cell Carcinoma

Cited by 16 publications

References 22 publications

825 Comparison of Baseline Quality of Life Measures Between Renal Cell Carcinoma Patients Undergoing Partial Versus Radical Nephrectomy

825 Comparison of Baseline Quality of Life Measures Between Renal Cell Carcinoma Patients Undergoing Partial Versus Radical Nephrectomy

Comparison of baseline quality of life measures between renal cell carcinoma patients undergoing partial versus radical nephrectomy

Psychoonkologische Aspekte urologischer Tumorerkrankungen

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