Quality of life of patients with Psoriasis in Alexandria- Egypt

Sharaf, Amany Youssef; Ibrahim, Alyaa Farouk Abd El-Fattah

doi:10.9790/1959-0601061729

Cited by 5 publications

(9 citation statements)

References 43 publications

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“…(29) This may be explained by that younger patients pay more attention to their shape than elderly patients, so the disease effect on their QOL is greater. However; results of study done (28) Additionally, it was noted that patients with higher income was significantly associated with lower total DLQI score which mean better QOL (Table 6). Patients with higher monthly income can buy expensive medications which may be unavailable at public hospitals all the time and this might be reflected positively on their QOL.…”

Section: Discussionmentioning

confidence: 95%

“…Psoriasis is a serious dermatological disease extending beyond the physical symptoms experienced by the patient, and seriously affecting the way in which the patient sees him /herself and the way he/she is seen by others. (28) In general, the commonly used measures of psoriasis activity are PASI and BSA. (29) The most widely used QOL questionnaire is the DLQI which is short and easy to use.…”

Section: Discussionmentioning

confidence: 99%

“…al. (28) This may be due that most husbands (wives) understand the non-infectious nature of the disease and encourage their husbands(wives) to cure and recover. However; contrary to current results, Głowacka et.…”

Section: Discussionmentioning

confidence: 99%

“…However; contrary to current results, Głowacka et. al., illustrated that psoriasis limit patients' sexual life because of their embarrassment (28) . Studying the association between total DLQI score with various socio-demographic and disease characteristics variables of the participants revealed a significant negative association between age and total DLQI score (Table 6).…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Quality of Life in a Sample of Iraqi Patients with Psoriasis.

Abdulridha¹,

Kadhim²,

Razzak³

2020

IJPS

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Psoriasis is a dermatological, chronic, immune-mediated condition. Psoriasis symptoms are not associated with physical burden only, but it may also have psychosocial effects on patients, diminished cognitive control, poor body image and impairments in everyday life. The value of quality of life is important since improving it is the principal goal for non-curative disease. The aim of the current study was to evaluate quality of life in a sample of Iraqi patients with psoriasis. This study is a cross-sectional study that involved 300 already diagnosed psoriasis patients who attended to the center of Dermatology and Venereology, Medical City/Baghdad. The mean age of patients was (35.156 ±10.549 years). The Arabic version of Dermatology Life Quality Index was used to assess quality of life. The mean total score is 11.29± 5.45 and the majority of the patients (53.7%) had a total score of more than 10, which indicates a significant deterioration in patients’ quality of life. The greatest impact was found in symptoms and feelings (mean = 1.66 ± 0.75) while the lowest impact was noted in personal relationships (0.51± 0.65). Increasing age and monthly income as well as vulgaris type of psoriasis associated significantly better quality of life. While Psoriasis Area and Severity Index associated significantly worse quality of life. In conclusion, psoriasis exerts significant, negative impact on patients’ quality of life, especially among those with younger age, lower monthly income, high disease activity, and types of psoriasis other than vulgaris.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Assessment of Quality of Life in a Sample of Iraqi Patients with Psoriasis.

Abdulridha¹,

Kadhim²,

Razzak³

2020

IJPS

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“…Psoriasis prevalence is now in increase. It is a serious dermatological disease extending beyond the physical symptoms as it exerts significant, negative impact on patients' quality of life (3) .…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Expression of Heparanase-2 in Psoriasis

Samaka

Shoieb

Abdo³

2021

The Egyptian Journal of Hospital Medicine

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Background: Psoriasis is a chronic, inflammatory immune mediated skin disease characterized by dense infiltrates of immunocytes especially macrophages. Cross talk between immunocytes and keratinocytes is thought to mediate the disease. Hparanase 2 inhibits activity of Heparanase 1 which is involved in this cross talk by degradation of heparin sulphate chains in the basement membrane and extra cellular matrix (ECM). Objective: To assess the of Heparanase2 in psoriasis through its immunohistochemical expression in lesional and perilesional skin of psoriasis patients. Patients and Methods: This prospective case control study was carried out on a total number of 60 subjects, they included 30 patients with chronic plaque psoriasis and 30 age and gender matched apparently normal subjects as control group. Skin biopsies were taken for immunohistochemical evaluation of Heparanase 2 expression. Results: Our results showed significant difference between lesional, perilesional and control groups regarding the status of epidermal Heparanase 2 expression (P = 0.038). All lesional epidermal expression was negative while perilesional epidermal expression was negative in 24 (80%) cases and positive in 6 (20%) cases, control epidermal expression was negative in 27 (90%) cases and positive in 3 (10%) cases. There was no significant difference between the three studied groups regarding dermal Heparanase 2 expression (P = 0.318). Conclusion: Downregulation of Heparanase 2 could be incriminated in the pathogenesis of psoriasis. Heparanase 2 could have a protective role in skin.

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