Quality of Life of Patients with Neurological Conditions and Neuropathic Pain

Аманова, Э О; Abassova, G.; Kaishibayeva, Gulnaz; Ковальчук, В В

doi:10.5958/0974-360x.2018.00092.6

Rese. Jour. of Pharm. and Technol.

2018

DOI: 10.5958/0974-360x.2018.00092.6

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Quality of Life of Patients with Neurological Conditions and Neuropathic Pain

Э О Аманова¹,

G. Abassova²,

Gulnaz Kaishibayeva³

et al.

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2022

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The Neuroprotective and Antinociceptive effect of Antidiabetic 3-(2-chlorophenyl)-4-imino-5-phenyl-2-(2-methoxyphenyl)-2H,3H,5H-[1,2,5]thiadiazolidin-1-oxide (CIPMTO) in Streptozotocin-induced diabetic neuropathic pain in rats: primary proof of concept

Kaur¹,

Kaur²,

Muthuraman

et al. 2022

RJPT

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In this study the neuroprotective and antinociceptive effect of a newly synthesized chemical moiety, a thiazolidin derivative, 3-(2-chlorophenyl)-4-imino-5-phenyl-2-(2-methoxyphenyl)-2H,3H,5H-[1,2,5]thiadiazolidin-1-oxide (CIPMTO) in streptozotocin (STZ) induced diabetic neuropathic pain is examined in rat therapeutic model. Multiple behavior and biochemical parameters were assessed on the therapeutic model to understand the role of CIPMTO. In this study, male Wistar rats (220-250 g) were used (7 groups, one group was not given any kind of chemical treatment (normal control). All other 6 groups were given a dose of STZ. Carboxymethylcellulose (CMC) was used as a vehicle for CIPMTO in this study. Out of those 6 groups, 1 group was given no other treatment (negative control), 1 group was given CMC only (Vehicle control), 3 groups were treated with different doses of CIPMTO, and 1 group was treated with pregabalin (positive control). Thereafter multiple behavioral studies and biochemical testing were carried out. CIPMTO is found to attenuate the STZ induced behavioral and biochemical changes in a dose-dependent manner (5, 10, and 15 mg/kg) as compared to that of the pregabalin-treated group. CIPMTO also reduced STZ-induced diabetic NP, which is attributable to its neuroprotective potential via pharmacological activities such as free radical scavenging, anti-lipid peroxidation, and inhibition of intracellular calcium accumulation. The current study shows that CIPMTO has neuroprotective and antinociceptive properties, as well as the ability to reduce neuropathic pain. Though further research and testing could be conducted for establishing the fact.

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The Neuroprotective and Antinociceptive effect of Antidiabetic 3-(2-chlorophenyl)-4-imino-5-phenyl-2-(2-methoxyphenyl)-2H,3H,5H-[1,2,5]thiadiazolidin-1-oxide (CIPMTO) in Streptozotocin-induced diabetic neuropathic pain in rats: primary proof of concept

Kaur¹,

Kaur²,

Muthuraman

et al. 2022

RJPT

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show abstract

Current Therapeutic Targets for Neuropathic Pain

Surana¹,

Parkhe

Ahire³

et al. 2022

AJPR

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Nociceptive ache signals the frame to capability or real tissue harm. By contrast, neuropathic ache, which ends from damage or harm to the worried system, persists lengthy in spite of everything symptoms and symptoms of the authentic damage have disappeared. This kind of maladaptive ache affords a full-size scientific problem, because it responds poorly or unpredictably to classical analgesics. There is likewise no single, uniformly well-tolerated drug this is reliably helpful. Neuropathic ache withinside the popular populace is expected to have a occurrence ranging among 3% and 17%. Most of the remedies for neuropathic ache have slight efficacy and gift aspect consequences that restriction their use; therefore, different healing strategies are wished for patients. In this article, the contemporary trendy of care treatment, the rising pharmacological strategies until date, and the preclinical research on novel promising healing alternatives could be reviewed.

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Quality of Life of Patients with Neurological Conditions and Neuropathic Pain

Cited by 2 publications

References 0 publications

The Neuroprotective and Antinociceptive effect of Antidiabetic 3-(2-chlorophenyl)-4-imino-5-phenyl-2-(2-methoxyphenyl)-2H,3H,5H-[1,2,5]thiadiazolidin-1-oxide (CIPMTO) in Streptozotocin-induced diabetic neuropathic pain in rats: primary proof of concept

The Neuroprotective and Antinociceptive effect of Antidiabetic 3-(2-chlorophenyl)-4-imino-5-phenyl-2-(2-methoxyphenyl)-2H,3H,5H-[1,2,5]thiadiazolidin-1-oxide (CIPMTO) in Streptozotocin-induced diabetic neuropathic pain in rats: primary proof of concept

Current Therapeutic Targets for Neuropathic Pain

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