Introduction: Diabetes mellitus is considered one of the crucial chronic diseases with several complications; people with type 2 diabetes have a lower quality of life than normal ones. Around the world, health related quality of life is widely used as a health outcome measurement. This study was conducted to assess the quality of life of patients with type diabetes mellitus (DM) and to determine some selected clinical and sociodemographic factors that affect the quality of life of these patients. Methods: A descriptive cross-sectional study design was used to assess the health-related quality of life of patients with diabetes mellitus. The study was achieved from 12th January 2021 to 2nd of August 2021. A purposive sample selection was used to collect data from (150) patients. The study tool was constructed by the researchers to meet the study's objectives including an adopted scale to measure health-related quality of life in diabetic patients, Participants were asked to complete three parts of the questionnaire: Part I socio-demographic data, Part II includes clinical data and Part III which measure health-related quality of life by using (Sf-12 short-form health survey) which measure health related quality of life for the diabetic patients. Results: The result shows the general health level of patients are fair (mean= 27.00Å}20.382), while physical role (mean= 25.33Å}43.631) and emotional role (mean= 23.33Å}42.437) are poor, on the other hand the physical function (mean= 48.50Å}37.161), bodily pain (mean=53.83Å}27.742), mental health (mean= 51.20Å}28.391), vitality (mean= 42.13Å}28.393) and social function (mean= 49.00Å}33.887) are at a moderate levels. The results show a significant association between the age, level of education, and monthly income of the patients in relation to physical and mental domains at a P-value ?0.001. Conclusion: The overall health of the patients was fair despite their physical and emotional well-being levels being poor. While physical function, vitality, and bodily pain, levels were demonstrated as moderate.