Quality of life of women with a history of adenomyosis and papillary thyroid carcinoma

Danylova, A.О.

doi:10.30841/2708-8731.1.2022.258143

RHW

2022

DOI: 10.30841/2708-8731.1.2022.258143

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Quality of life of women with a history of adenomyosis and papillary thyroid carcinoma

A.О. Danylova¹

Abstract: The objective: to assess the quality of life of women with a history of adenomyosis and papillary thyroid carcinoma (thyroid).Materials and methods. 124 women aged 24–45 years old were examined: the I group included 61 women with a history of adenomyosis and papillary thyroid carcinoma, and the II group included 63 women with adenomyosis and normal thyroid status. The severity of pelvic pain was assessed on a visual-analog scale (VAS) in the intermenstrual and menstrual periods. Quality of life of the persons … Show more

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Cited by 3 publications

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Characteristics of endometrial hormonal homeostasis and receptor apparatus in women with adenomyosus who had papillary thyroid carcinoma

Danylova

Kaluhina

Kosei³

et al. 2022

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Objectives: to evaluate the hormonal status and receptor apparatus of the eutopic endometrium in patients with adenomyosis who had a history of papillary thyroid carcinoma.Materials and methods. 63 women were examined: group I consisted of 31 patients with adenomyosis and papillary carcinoma of the thyroid gland in history, group II consisted of 32 patients with adenomyosis and unencumbered thyroid status. The severity of pelvic pain was assessed using a visual analog scale. The level of luteinizing and follicle-stimulating hormones, estradiol, prolactin, thyroid-stimulating hormone and progesterone was determined in the peripheral blood serum. The material for the morphological study was obtained using endometrial pipelle biopsy. Morphological research was performed on 30 biopsies of eutopic endometrium (15 samples from patients of group I and 15 samples from patients of group II). Immunohistochemical study was performed on 20 paraffin sections (10 samples from patients of group I and 10 samples from patients of group II) using monoclonal antibodies.Results. High ER-α expression was detected in the endometrial glandular epithelial cells (EGECs) in 80 and 50% of samples of patients from groups I and II, respectively (р < 0.05), no significant difference in the number of positive cells was found between groups. High ER-α expression in endometrial stromal cells (ESCs) was detected in 50% of samples in patients from both groups, the number of positive cells was significantly higher in the endometrium specimens from I group (84.0 (10.5%) in group I versus 62.2 (12.3%) in group II, р < 0.05). High PgR expression in the EGECs was detected in 90 and 75% of samples in groups I and II respectively (р < 0.05), ESCs expressed PgR in 100% of samples of patients from both groups. Significant difference in the number of positive cells was found between groups – 96.0 (8.4%) and 84.9 (12.6%) in groups I and II respectively, р < 0.05.Conclusions. Our results suggest that the ectopic endometrium in female thyroid cancer survivors with adenomyosis has high expression of ER and PgR, that may have important implications for the survival and proliferation of the eutopic endometrial cells. Further research is needed to optimise prevention and treatment algorithms for this group of patients.

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Characteristics of endometrial hormonal homeostasis and receptor apparatus in women with adenomyosus who had papillary thyroid carcinoma

Danylova

Kaluhina

Kosei³

et al. 2022

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Immunohistochemical markers of the activity of apoptosis and proliferation in women with adenomyosis who had papillary thyroid carcinoma

Tronko,

Danylova,

Kalugina

et al. 2023

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Research objectives: to evaluate the activity of apoptosis and proliferation mechanisms of eutopic endometrium in patients with adenomyosis who had a history of papillary thyroid carcinoma (PTC).Materials and methods. 63 women of reproductive age were examined: group I – 31 patients with adenomyosis and PTC in history, group II – 32 patients with adenomyosis and normal thyroid status. The intensity of pelvic pain was assessed using a visual analog scale in all women. The material for morphological research was obtained with Pipelle biopsy of the endometrium in the secretory phase of the menstrual cycle. A morphological study was performed on 30 biopsies of eutopic endometrium (15 samples from patients of group I and 15 samples from patients of group II). An immunohistochemical study was performed using monoclonal antibodies to cell-specific markers Bcl-2 (DAKO, clone 124) and Ki-67 (DAKO, clone MIB-1).Results. High expression of Bcl-2 was detected in the endometrial glandular epithelial cells (EGECs) in 70% and 62.5% of samples in group I and II respectively (р > 0.05), the number of Bcl-2-positive cells was significantly higher in samples from group I (80.0 ± 13.1% versus 60.0 ± 15.2% in group І and ІІ respectively, р < 0.05). In endometrial stromal cells (ESCs) high expression of Bcl-2 was detected in 90% and 100% of samples from group I and II respectively (р > 0.05), no significant difference in the number of positive cells was found between groups (18.9 ± 12.2% and 12.6 ± 9.1% in group І and ІІ respectively, р > 0.05). Expression of Ki-67 was detected in the EGECs in 70% and 62.5% (р > 0.05) of samples in group І and ІІ respectively and in the ESCs in 100% of samples from groups I and II respectively. The immunocytochemical Ki-67 labelling index was much more prominent in group I (45.0 ± 11.4% versus 25.8 ± 16.7% EGECs (р < 0.05); 26.5 ± 10.2% versus 16.3 ± 8.9% ESCs (р < 0.05) for group I and II respectively).Conclusions. Altered proliferation of the eutopic endometrium with marked resistance to apoptosis was found in reproductive aged female with adenomyosis and PTC in history, that is can be considered as a marker of the aggressiveness of the disease course in this cohort of patients.

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Psychoemotional state and quality of life of nulliparous women with recurrent squamous epithelial exocervical dysplasia of the cervical epithelium in the perimenopausal period

Laskava

Benyuk

Shcherba

et al. 2022

RHW

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The objective: to study the features of the psychoemotional state and quality of life of nulliparous women with recurrent squamous epithelial exocervical dysplasia of the cervical epithelium in the perimenopausal period.Materials and methods. 60 nulliparous women with recurrent cervical epithelial flat dysplasia that occurred after treatment with surgical methods in the perimenopausal period (the main group) and 38 women without gynecological and somatic pathologies in the perimenopausal period (control group) were examined. All patients were examined in accordance with the regulatory orders of the Ministry of Health of Ukraine. The assessment of neurovegetative and psychoemotional manifestations was carried out according to the Kupperman index, indicators of the quality of life and the Lusher color test.Results. The data of the medical history and clinical examination of patients were evaluated. This makes possible to identify a risk group among nulliparous women in the perimenopausal period for the development of recurrent squamous epithelial exocervical dysplasia of the cervical epithelium.In the main group, an increase in the Kupperman menopausal index by almost 1.5 times was found, as well as a significant decrease in indicators of psychosocial adaptation according to Lusher test to 40% and quality of life (physical component of health was 72.5±6.4 and 93,1±4,7 points in the main and control groups, respectively, mental component – 54.2±4.1 and 91,4±2,3 points, respectively).Conclusions. In infertile women with the menopausal changes, the recurrent squamous epithelial exocervical dysplasia of the cervical epithelium is a form of complicated course of dysplasia, and has a multifactorial genesis, in which conditions arise for the implementation of the neoplastic process. The clinical manifestations of the complicated course of the perimenopausal period significantly worsen the quality of life and general health in nulliparous women, especially on the background of recurrent squamous epithelial exocervical dysplasia of the cervical epithelium after surgical treatment, which is evidenced by more pronounced climacteric manifestations, reduction of physical and social activities, and emotional status.

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Quality of life of women with a history of adenomyosis and papillary thyroid carcinoma

Cited by 3 publications

References 20 publications

Characteristics of endometrial hormonal homeostasis and receptor apparatus in women with adenomyosus who had papillary thyroid carcinoma

Characteristics of endometrial hormonal homeostasis and receptor apparatus in women with adenomyosus who had papillary thyroid carcinoma

Immunohistochemical markers of the activity of apoptosis and proliferation in women with adenomyosis who had papillary thyroid carcinoma

Psychoemotional state and quality of life of nulliparous women with recurrent squamous epithelial exocervical dysplasia of the cervical epithelium in the perimenopausal period

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