Quality-of-Life Priorities in Patients with Thyroid Cancer: A Multinational European Organisation for Research and Treatment of Cancer Phase I Study

Schnittger, Susanne; Husson, Olga; Tomaszewska, Iwona M.; Locati, Laura D.; Kiyota, Naomi; Scheidemann-Wesp, Ulrike; Hofmeister, Dirk; Winterbotham, Melanie; Brannan, Christine; Araújo, Cláudia; Gamper, Eva‐Maria; Kuliš, Danijela; Rimmele, Harald; Andry, Guy; Licitra, Lisa

doi:10.1089/thy.2015.0640

Cited by 51 publications

(50 citation statements)

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“…The second aim was to shorten the module without compromising its comprehensiveness. The patient responses confirmed that the QoL issues identified in phase I of this module development (Singer et al 2016) are relevant and important to patients. Most of the items were well accepted by the patients.…”

Section: Discussionsupporting

confidence: 58%

“…The European Organisation for Research and Treatment of Cancer (EORTC) therefore created a thyroid-cancer-specific module to be used as a supplement of the quality-of-life core questionnaire EORTC QLQ-C30 (phase I and II of the EORTC module development process (Johnson et al 2011)). This (provisional) module was developed based on two systematic reviews and structured interviews with 110 patients and 57 health care professionals (Singer et al 2016). In these previous phases, items were derived from a longer list of QoL issues that could be relevant for thyroid cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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The EORTC module for quality of life in patients with thyroid cancer: phase III

Schnittger¹,

Jordan

Locati

et al. 2017

Endocrine-Related Cancer

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The purpose of the study was to pilot-test a questionnaire measuring health-related quality of life (QoL) in thyroid cancer patients to be used with the European Organisation for Research and Treatment of Cancer (EORTC) core questionnaire EORTC QLQ-C30. A provisional questionnaire with 47 items was administered to patients treated for thyroid cancer within the last 2 years. Patients were interviewed about time and help needed to complete the questionnaire, and whether they found the items understandable, confusing or annoying. Items were kept in the questionnaire if they fulfilled pre-defined criteria: relevant to the patients, easy to understand, not confusing, few missing values, neither floor nor ceiling effects, and high variance. A total of 182 thyroid cancer patients in 15 countries participated ( = 115 with papillary, = 31 with follicular, = 22 with medullary, = 6 with anaplastic, and = 8 with other types of thyroid cancer). Sixty-six percent of the patients needed 15 min or less to complete the questionnaire. Of the 47 items, 31 fulfilled the predefined criteria and were kept unchanged, 14 were removed, and 2 were changed. Shoulder dysfunction was mentioned by 5 patients as missing and an item covering this issue was added. To conclude, the EORTC quality of life module for thyroid cancer (EORTC QLQ-THY34) is ready for the final validation phase IV.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

The EORTC module for quality of life in patients with thyroid cancer: phase III

Schnittger¹,

Jordan

Locati

et al. 2017

Endocrine-Related Cancer

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“…Symptoms can be caused by the disease itself or by treatment-related side effects. The symptom burden exerts a significant impact on the quality of life and is highly prioritised by patients with thyroid cancer 27 . A problem-solving approach in the management of symptom problems is generally recommended 28 .…”

Section: Discussionmentioning

confidence: 99%

Association between subjective symptoms and obesity and postoperative recurrence in differentiated thyroid cancer: a matched-pair analysis

Cheng

Chiou

et al. 2020

Sci Rep

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and imaging data collected during follow-up. The current risk scheme of thyroid cancer has insufficient input of clinical symptomatology and assessment by the healthcare givers. Large cohort studies have demonstrated that patients with thyroid cancer experience symptom distress frequently after diagnosis, which negatively affects their quality of life 8-10. Furthermore, thyroid cancer survivors reported worse quality of life in the domains of anxiety, depression, fatigue, and sleep disturbance than individuals with other cancers 11. In some cancer types, patient-perceived symptoms are the most frequent indicators of recurrence 12,13. However, it remains unknown whether subjective symptoms are associated with thyroid cancer recurrence. Additionally, some controversies regarding the association between obesity and aggressive features of thyroid cancer exist 14,15. It will be interesting to investigate the association between obesity and patient symptoms. In the present study, we aimed to evaluate whether subjective symptoms and obesity are associated with disease recurrence of thyroid cancer. Hence, we performed a matched-pair analysis to compare self-reported symptoms and body mass index (BMI) between patients with and without recurrence. Methods Patients and data collection. We queried our prospectively maintained database from a medical center to retrospectively review and identify eligible patients. All data collection and analysis were performed after the study was approved by the Institutional Review Board of MacKay Memorial Hospital (18MMHIS154), which waived the need for patient consent. All identifiable profiles of each patient were unlinked to protect the patients privacy. The inclusion criterion for this study was as follows: adult patients who underwent lobectomy or total thyroidectomy for differentiated thyroid cancer from 2001 to 2017. The exclusion criteria included the following: patients undergoing biopsy only, the index operation performed elsewhere, age younger than 20 years at diagnosis, second primary malignancy other than thyroid cancer, and short follow-up (<6 months). Patient demographics, comorbidities, tumour histology, and laboratory and imaging results were obtained from inpatient, outpatient, and procedure records.

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“…According to the personal experience of this first author, issues related to thyroid diseases and thyroid surgery are rarely discussed in either undergraduate or graduate level courses in speech-language pathology. Therefore, the need for continuing education in thyroid disease and treatment, and increased awareness of a multidisciplinary approach to treatment is essential for all associated healthcare professionals and would be highly beneficial to these patients (6,77).…”

Section: Discussionmentioning

confidence: 99%

Speech therapy after thyroidectomy

2017

Gland Surg.

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Common complaints of patients who have received thyroidectomy include dysphonia (voice dysfunction) and dysphagia (difficulty swallowing). One cause of these surgical outcomes is recurrent laryngeal nerve paralysis. Many studies have discussed the effectiveness of speech therapy (e.g., voice therapy and dysphagia therapy) for improving dysphonia and dysphagia, but not specifically in patients who have received thyroidectomy. Therefore, the aim of this paper was to discuss issues regarding speech therapy such as voice therapy and dysphagia for patients after thyroidectomy. Another aim was to review the literature on speech therapy for patients with recurrent laryngeal nerve paralysis after thyroidectomy. Databases used for the literature review in this study included, PubMed, MEDLINE, Academic Search Primer, ERIC, CINAHL Plus, and EBSCO. The articles retrieved by database searches were classified and screened for relevance by using EndNote. Of the 936 articles retrieved, 18 discussed "voice assessment and thyroidectomy", 3 discussed "voice therapy and thyroidectomy", and 11 discussed "surgical interventions for voice restoration after thyroidectomy". Only 3 studies discussed topics related to "swallowing function assessment/treatment and thyroidectomy". Although many studies have investigated voice changes and assessment methods in thyroidectomy patients, few recent studies have investigated speech therapy after thyroidectomy. Additionally, some studies have addressed dysphagia after thyroidectomy, but few have discussed assessment and treatment of dysphagia after thyroidectomy.

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Quality-of-Life Priorities in Patients with Thyroid Cancer: A Multinational European Organisation for Research and Treatment of Cancer Phase I Study

Cited by 51 publications

References 51 publications

The EORTC module for quality of life in patients with thyroid cancer: phase III

The EORTC module for quality of life in patients with thyroid cancer: phase III

Association between subjective symptoms and obesity and postoperative recurrence in differentiated thyroid cancer: a matched-pair analysis

Speech therapy after thyroidectomy

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