Quality of Life, Symptomatology and Healthcare Utilization in HIV/HCV Co-Infected Drug Users in Miami

Baum, Marianna K.; Jayaweera, Dushyantha; Duan, Rui; Sales, Sabrina; Lai, Shenghan; Rafie, Carlin; Regev, Arie; Page, J. Bryan; Berkman, Ronald; Campa, Adriana

doi:10.1300/j069v27n02_05

Cited by 33 publications

(30 citation statements)

References 39 publications

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“…Consistent with our prediction, and supporting previous literature (Baum et al, 2008;Braitstein et al, 2005), our findings indicated that co-infected patients exhibited lower QoL in the four QoL domains, compared to patients with HIV only. Our findings also partially agree with prior studies that found reduced physical QoL among co-infected patients compared to patients with HIV only (Tsui et al, 2007) and that co-infection with HCV is related to lower mental health scores (Briongos Figuero et al, 2011).…”

Section: Discussionsupporting

confidence: 93%

“…Despite this expectation, the literature contains inconsistent findings regarding the QoL of HIV/HCV patients. These mixed findings include studies that have reported that QoL is decreased in co-infected patients compared to HIV mono-infected patients (Baum et al, 2008), that only physical aspects of QoL are decreased in co-infected patients compared to mono-infected patients 4 (Tsui et al, 2007), and that QoL in co-infected patients is decreased compared only to controls and not compared to HIV-negative or HCV-negative mono-infected patients (Fleming et al, 2004). Other studies did not find significant differences in QoL between HIV/HCV patients and HIV or HCV mono-infected patients Pantalone et al, 2012).…”

mentioning

confidence: 99%

“…Understanding this association among co-infected patients is critical primarily due to the association between psychological status and QoL and its potentially negative association with adherence to anti-retroviral treatments (Blashill et al, 2011;Roux et al, 2014;Sherr et al, 2008). There is evidence suggesting that co-infected patients report significantly more psychological symptoms than HIV mono-infected patients particularly somatic (Baum et al, 2008;Hilsabeck et al, 2003) and depressive symptoms (Baum et al, 2008;Braitstein et al, 2005;Gillis et al, 2013;Pantalone et al, 2012;Yoon et al, 2011). Also, it has been shown that patients with higher levels of psychological distress exhibit reduced QoL, and strong negative associations between symptoms of psychological distress and QoL have been reported in HIV (Pereira & Canavarro, 2011;Préau et al, 2007a), HCV (Fontana et al, 2002;Hauser et al, 2004) and HIV/HCV (Marcellin et al, 2007;Pereira et al, 2014).…”

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confidence: 99%

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Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

Pereira

Fialho

2016

J Behav Med

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This study compared the quality of life (QoL) of HIV-infected patients with and without hepatitis C and examined the sociodemographic, HIV-related and psychological symptoms associated with the QoL domains in patients with HIV/HCV co-infection. The sample consisted of 248 HIV/HCV coinfected patients (18-74 years, 81.5% male) and 482 patients only with HIV (24-78 years, 62.7% male). Participants completed the WHOQOL-HIV-Bref questionnaire and the Brief Symptom Inventory (BSI). The HIV/HCV co-infected patients reported significantly lower QoL in all domains, as well as significantly lower scores in 10 of the 17 specific facets. Overall, among the co-infected patients, male gender, employment, combination antiretroviral therapy use and fewer depressive and anxiety symptoms were significantly associated with higher QoL. Symptoms of psychological distress accounted for significant variability in the QoL scores of co-infected patients. These data reinforce the need for tailored interventions to improve the overall well-being of HIV/HCV co-infected patients.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

Pereira

Fialho

2016

J Behav Med

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“…Hepatitis C co-infection was not associated with depression in multivariable analyses in our study, but has been independently prognostic of depression in other HIV cohorts. 51,52 We performed separate analyses by sex to elucidate factors associated with the high rates of depression in women. While Hispanics and non-Hispanic blacks were more likely to be depressed overall, Hispanic women had the highest rates of depression (as shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

Sadness in the SUN: Using Computerized Screening to Analyze Correlates of Depression and Adherence in HIV-Infected Adults in the United States

Tedaldi

Berg-Wolf

Richardson

et al. 2012

AIDS Patient Care and STDs

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We used a standardized screening tool to examine frequency of depression and its relation to antiretroviral medication adherence among HIV-infected persons on highly active antiretroviral therapy (HAART) in the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study). This is a prospective observational cohort of 700 HIV-infected patients enrolled between March 2004 and June 2006 in four U.S. cities, who completed a confidential audio computer-assisted self-interview [ACASI] with behavioral risk and health-related questions at baseline and 6-month follow-up visits, including the nine-question PRIME-MD depression screener and a validated 3-day antiretroviral adherence question. Among 539 eligible participants receiving HAART, 14% had depression at baseline (22% women, 12% men). In multivariable analysis using generalized estimating equations (GEE) to account for repeated measurements through 24 months of follow-up, persons who reported depression on a given ACASI were twice as likely to report nonadherence to antiretrovirals on the same ACASI (Odds ratio [OR] 2.02, 95% CI: 1.15, 3.57] for mild/moderate depression versus none); such persons were also less likely to have HIV viral load < 400 copies/mL. Self-administered computerized standardized screening tools can identify at-risk individuals with depression who may benefit from interventions to improve antiretroviral adherence.

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“…No caso relatado neste artigo, o paciente apresentava sorologia positiva ao HIV e ao HCV. Na literatura, encontram-se diversas referências ao impacto que o diagnóstico de infecção pelo HIV causa no estado mental, desde transtornos de ajustamento a alterações cognitivas [7][8] . Também é reconhecido o impacto do tratamento para hepatite C no humor dos pacientes, como no caso citado, no qual interferon foi a droga escolhida, que tipicamente causa humor disfórico ou depressivo 9 .…”

Section: Comentáriosunclassified

Comorbidades entre dependência química, distimia, HIV e HCV: relato de caso

Marsden¹

2009

Rev. psiquiatr. clín.

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ResumoIntrodução: A comorbidade entre dependência química e doenças infectocontagiosas é bem conhecida, assim como a relação entre transtornos de humor e uso de substâncias. Entretanto, o transtorno distímico nestes pacientes recebe pouca atenção. Em parte, isso se justifica porque a realização do diagnóstico de distimia é mais difícil do que de outros transtornos do humor em razão do tempo de abstinência (2 anos) necessário para o diagnóstico, tendo em vista que toxicodependentes apresentam diversas recaídas durante o curso de suas vidas. As infecções pelos vírus HIV e HCV, frequentemente associadas ao consumo injetável de substâncias, contribuem para alterações do estado mental e o próprio tratamento pode causar diversas flutuações no humor. Relato de caso: O paciente é um homem de 40 anos de idade que apresenta comorbidade entre dependência química (heroína e álcool) e distimia, complicada por recaídas, consumo injetável e status sorológico positivo aos vírus HIV-1 e HCV. Conclusão: Pacientes dependentes químicos com comorbidades psiquiátricas e infectocontagiosas são desafiadores no que tange diagnóstico, tratamento e definição de abordagens terapêuticas para os diferentes problemas apresentados. Investigar e abordar adequadamente, entretanto, traz diversos benefícios na qualidade de vida do indivíduo afetado, assim como potenciais benefícios financeiros. Marsden VFMG / Rev Psiq Clín. 2009;36(1):31-33Palavras-chave: Comorbidade, transtorno distímico, dependência de heroína, alcoolismo. AbstractBackground: Comorbidity between chemical dependence and infectious diseases is well known, as is the relationship between mood disorders and substance misuse. Nevertheless, dysthymia in these patients is not well explored. That is partly justified since the diagnoses of dysthymia is more difficult than other mood disorders due to the abstinence time (2 years) required for the diagnoses, and since addiction patients present several relapses during the course of their lifetimes. HIV and HCV infections, frequently associated to intravenous (IV) drug use, contribute to mental status deterioration and the treatment for such conditions can cause fluctuations on mood. Case report: A 40 years old patient with comorbidity between chemical dependence (heroin and alcohol) and dysthymia, complicated by relapses, IV drug use and serological status positive to HIV-1 and HCV. Conclusion: Addiction patients with psychiatric and infectious comorbidity are challenging to diagnose, treat and define therapeutical approaches to the different conditions. Proper clinical investigation and approach leads to benefits in health quality and potential financial benefits.

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Quality of Life, Symptomatology and Healthcare Utilization in HIV/HCV Co-Infected Drug Users in Miami

Cited by 33 publications

References 39 publications

Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

Sadness in the SUN: Using Computerized Screening to Analyze Correlates of Depression and Adherence in HIV-Infected Adults in the United States

Comorbidades entre dependência química, distimia, HIV e HCV: relato de caso

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