Quality of scaffold fixation in a human cadaver knee model

Abstract

This study showed that optimal fixation cannot be combined always with high scaffold integrity. Special attention devoted to scaffold properties in relation to the fixation technique may result in an improvement of scaffold fixation, and thus clinical cartilage regenerative approaches involving these scaffolds.

Comparison of four chondral repair techniques in the hip joint: a biomechanical study using a physiological human cadaveric model

“…The closest approximation to the natural environment is offered by the human cadaveric hip, which could be used to simulate the gait cycle in the post-operative rehabilitation period 10,12 . Previous studies testing cartilage repair in a cadaveric model have used simple sinus cyclic loading in both the knee and hip joint 19,21,36 . Fontana et al have recently reported on the stability of polydioxanone scaffolds in a cadaveric hip joint using continues passive motion performed by a manual operator 36 .…”

“…Our study is the first study to compare four different cartilage repair techniques in a human cadaveric hip joint under physiological loading. A complete gait cycle at 25% weight bearing was used to simulate the initial phase of rehabilitation after cartilage repair techniques and while other studies have used an end point of maximum of 300 cycles 19,21 , in this study an endpoint of 1500 gait cycles was used, which is equivalent to half a day of walking in the average healthy individual 32e34 .…”

“…Mechanical properties of scaffolds are usually evaluated by doing compression tests to characterise elasticity, durability and stability under load 20 . Various authors have carried biomechanical studies to assess the stability of implanted scaffolds in cadaveric knees using continuous passive motion (CPM) 19,21 . While tissue engineered constructs are attaining popularity in treating defects in the knee, to our knowledge, these scaffolds have not been biomechanically tested in a physiological cadaveric hip model.…”

Pronounced Biomaterial Dependency in Cartilage Regeneration Using Nonexpanded Compared with Expanded Chondrocytes

“…The Polyactive scaffold was prepared as previously described [18]. In brief, PEOT-PBT co polymer granules (PoroGen BV, The Netherlands) with a 1000/70/30 composition (70/30 PEOT/PBT and a PEG molecular weight of 1000) were printed using a 3D fiber deposition technique [19] with the BioScaffolder system (SysEng, Germany).…”

A new approach to scaffold fixation by magnetic forces: Application to large osteochondral defects

“…The method can be supported by applying biodegradable pins, fibrin glue, and cartilage or transosseous sutures [4][5][6][7]. However a sufficiently firm fixation through these techniques is scarcely compatible with the preservation of the scaffold integrity.…”