Quality of service support in mobile Ad Hoc networks

Shao, Wenjian; 邵文簡.,

doi:10.5353/th_b3704215

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fluorescent property of aldehyde-protected tricyclic chromenone compounds could be used to visualize the subcellular localization and evaluate intracellular pharmacokinetics of the inhibitors. [29][30] We examined the fluorescence of methoxy-containing tricyclic chromenone derivatives, and confirmed that D-F07 and 13, both harboring the 1,3-dioxane protecting group, emitted bright fluorescence at 460 nm ( Figures 3E and S7), while 15, bearing the N-acetylhydrazone protecting group, showed weak fluorescence. Since D-F07 could emit strong blue fluorescence and had the most potent effect in inhibiting the expression of XBP-1s in whole cells, we further modified the hydroxy group of D-F07 with 4-isopropyl-3-nitrobenzoate ( Figure 4A) because this photo-labile moiety could quench the fluorescence from coumarin and could be efficiently cleaved by UV irradiation.…”

Section: Installation Of a Photo-labile Cage On The C8 Hydroxy Of D-fmentioning

confidence: 86%

Structural Tailoring of a Novel Fluorescent IRE-1 RNase Inhibitor to Precisely Control Its Activity

et al. 2019

View full text Add to dashboard Cite

Activation of the IRE-1/XBP-1 pathway has been linked to many human diseases. We report a novel fluorescent tricyclic chromenone inhibitor, D-F07, in which we incorporated a 9-methoxy group onto the chromenone core to enhance its potency and masked the aldehyde to achieve longterm efficacy. Protection of the aldehyde as a 1,3-dioxane acetal led to strong fluorescence emitted by the coumarin chromophore, enabling D-F07 to be tracked inside the cell. We installed a photolabile structural cage on the hydroxy group of D-F07 to generate PC-D-F07. Such a modification significantly stabilized the 1,3-dioxane acetal protecting group, allowing for specific stimulusmediated control of inhibitory activity. Upon photo-activation, the re-exposed hydroxy group on D-F07 triggered the aldehyde-protecting 1,3-dioxane acetal to slowly decompose, leading to the inhibition of the RNase activity of IRE-1. Our novel findings will also allow for spatiotemporal control of the inhibitory effect of other salicylaldehyde-based compounds currently in development.

show abstract

Section: Installation Of a Photo-labile Cage On The C8 Hydroxy Of D-fmentioning

confidence: 86%