Quality of sleep in women with menopause and its related factors

Ahmady, Fatemeh; Niknami, Maryam; Khalesi, Zahra Bostani

doi:10.5935/1984-0063.20220021

Cited by 9 publications

(5 citation statements)

References 24 publications

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“…This perception may hinder timely interventions and exacerbate the impact of sleep disorders on overall well-being. To address this attitude, interventions should target misconceptions about the normalcy of sleep disorders during perimenopause 29 , 30 . Educational campaigns can incorporate narratives from individuals who have successfully managed sleep issues during this life stage, emphasizing the benefits of seeking professional guidance.…”

Section: Discussionmentioning

confidence: 99%

Knowledge, attitude, and practice toward sleep disorders and sleep hygiene among perimenopausal women

Shi,

Wang

et al. 2024

Sci Rep

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This cross-sectional study aimed to explore the knowledge, attitude and practice (KAP) toward sleep disorders and sleep hygiene among perimenopausal women, who were enrolled in Dezhou region of Shandong Province between July and September 2023. A total of 720 valid questionnaires were collected (mean age: 51.28 ± 4.32 years old), and 344 (47.78%) reported experiencing insomnia. The mean scores for knowledge, attitude, practice, and Dysfunctional Beliefs and Attitudes about Sleep (DBAS) were 15.73 ± 7.60 (possible range: 0–36), 29.35 ± 3.15 (possible range: 10–50), 28.54 ± 4.03 (possible range: 10–50), and 6.79 ± 1.90 (possible range: 0–10), respectively. Path analysis showed that knowledge had direct effects on attitude (β = 0.04, 95% CI 0.01–0.07, P = 0.001), and DBAS (β = 0.04, 95% CI 0.02–0.05, P < 0.001). Knowledge had direct effects (β = 0.11, 95% CI 0.08–0.15, P < 0.001) and indirect (β = 0.02, 95% CI 0.00–0.03, P = 0.002) effect on practice. Moreover, attitude also had a direct impact on practice (β = 0.34, 95% CI 0.25–0.43, P < 0.001). In conclusion, perimenopausal women exhibited insufficient knowledge, negative attitude, inactive practice toward sleep disorders and sleep hygiene, and unfavorable DBAS, emphasizing the need for targeted healthcare interventions.

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Section: Discussionmentioning

confidence: 99%

Knowledge, attitude, and practice toward sleep disorders and sleep hygiene among perimenopausal women

Shi,

Wang

et al. 2024

Sci Rep

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“…Subjective sleep quality, which encompasses waking after sleep onset, number of awakenings, sleep latency, and sleep efficiency, has been reported to decline in a linear fashion with increasing age. 1 , 4 , 5 , 9 , 10 , 11 , 12 Postmenopausal women are more likely to report sleep disorders than their premenopausal counterparts and among postmenopausal women, those with surgically induced menopause have worse sleep quality than those with naturally occurring menopause. 1 , 4 , 13 , 14 Data on the impact of hormone therapy (HT) on sleep quality during the menopausal transition are conflicting.…”

Section: Background and Aimsmentioning

confidence: 99%

Perceived quality of sleep across the menopausal transition: A retrospective cohort study

Maxwell

Reisinger‐Kindle

Rackett

et al. 2023

Health Science Reports

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Background and Aims To compare sleep quality among naturally and surgically post‐menopausal women, and to identify lifestyle factors that predict sleep quality in pre, peri, and postmenopausal women. Methods This is a retrospective cohort study of data collected from 429 women who participated in Fels Longitudinal Study data. Sleep quality, based on the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale, demographics, medical history, depression, quality of life, and physical activity levels were included in the analysis. Results The four study groups did not differ on overall sleep quality with either scale (p = 0.61). Both Post‐M groups were more likely to have a major sleep problem than the Peri‐M and Pre‐M groups (p < 0.001), and to have a history of restless leg syndrome (p = 0.016), but the two Post‐M groups did not differ on these problems. Predictors of sleep quality included depression, bodily pain, vitality, and surgical menopause (p<0.001). Conclusion Menopause is associated with sleep disrupting conditions. This study did not find any significant differences in sleep quality among the three reproductive stages or for natural versus surgical menopause. Women may benefit from addressing other lifestyle factors associated with poor sleep quality including mental health factors.

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“…In animal and in vitro studies, oestrogen was found to play several neuroprotective roles including promoting survival of cholinergic neurons, metabolism of APP through the non-amyloidogenic pathway, and via antioxidant properties [53]. Hormonal changes experienced in menopause can result in altered sleeping patterns [54] and cognitive dysfunction [55]. Individually, these symptoms are risk factors for AD, but in combination with decreasing oestrogen, they may explain why women are at a higher risk of developing the disease than men [50,52].…”

Section: Non-modifiable Risk Factorsmentioning

confidence: 99%

The Potential of a Stratified Approach to Drug Repurposing in Alzheimer’s Disease

Anderson,

Bucholc,

McClean

et al. 2023

Biomolecules

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Alzheimer’s disease (AD) is a complex neurodegenerative condition that is characterized by the build-up of amyloid-beta plaques and neurofibrillary tangles. While multiple theories explaining the aetiology of the disease have been suggested, the underlying cause of the disease is still unknown. Despite this, several modifiable and non-modifiable factors that increase the risk of developing AD have been identified. To date, only eight AD drugs have ever gained regulatory approval, including six symptomatic and two disease-modifying drugs. However, not all are available in all countries and high costs associated with new disease-modifying biologics prevent large proportions of the patient population from accessing them. With the current patient population expected to triple by 2050, it is imperative that new, effective, and affordable drugs become available to patients. Traditional drug development strategies have a 99% failure rate in AD, which is far higher than in other disease areas. Even when a drug does reach the market, additional barriers such as high cost and lack of accessibility prevent patients from benefiting from them. In this review, we discuss how a stratified medicine drug repurposing approach may address some of the limitations and barriers that traditional strategies face in relation to drug development in AD. We believe that novel, stratified drug repurposing studies may expedite the discovery of alternative, effective, and more affordable treatment options for a rapidly expanding patient population in comparison with traditional drug development methods.

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Quality of sleep in women with menopause and its related factors

Cited by 9 publications

References 24 publications

Knowledge, attitude, and practice toward sleep disorders and sleep hygiene among perimenopausal women

Knowledge, attitude, and practice toward sleep disorders and sleep hygiene among perimenopausal women

Perceived quality of sleep across the menopausal transition: A retrospective cohort study

The Potential of a Stratified Approach to Drug Repurposing in Alzheimer’s Disease

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