Quality of the Threshold Algorithm in Age-Related Macular Degeneration: Stratus versus Cirrus OCT

Krebs, Ilse; Falkner-Radler, Christiane I.; Hagen, Stefan; Haas, Paulina; Brannath, Werner; Lie, Shilla; Ansari-Shahrezaei, Siamak; Binder, Susanne

doi:10.1167/iovs.08-2617

Cited by 32 publications

(27 citation statements)

References 19 publications

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“…Such errors in the automated detection of Bruch’s membrane induce wrong quantification of retinal thickness and may lead to erroneous decision of retreatment. Based on this automated retinal thickness, our findings are comparable to results previously obtained with Cirrus SD-OCT and Spectralis SD-OCT [21,25,26,27]. While the inner limiting membrane is always well defined, Bruch’s membrane was poorly defined in several cases, particularly in geographic atrophy [28].…”

Section: Discussionsupporting

confidence: 87%

“…SD-OCT led to a precise identification of retinal lesions in chorioretinal diseases with a greater qualitative follow-up [1,2,19,20]. Also, this device allows an automated threshold delineation more accurately thanks to its higher resolution imaging and an improved scanning speed [14,21]. The Spectralis SD-OCT software can locate the inner limiting membrane and Bruch’s membrane, allowing a quantitative analysis useful for the follow-up of AMD patients.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of a Spectral Domain OCT Segmentation Software in a Retrospective Cohort Study of Exudative AMD Patients

Tilleul

Querques²,

Canouï‐Poitrine³

et al. 2012

Ophthalmologica

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Background: To assess the ability of the Spectralis optical coherence tomography (OCT) segmentation software to identify the inner limiting membrane and Bruch’s membrane in exudative age-related macular degeneration (AMD) patients. Methods: Thirty-eight eyes of 38 naive exudative AMD patients were retrospectively included. They all had a complete ophthalmologic examination including Spectralis OCT at baseline, at month 1 and 2. Reliability of the segmentation software was assessed by 2 ophthalmologists. Reliability of the segmentation software was defined as good if both inner limiting membrane and Bruch’s membrane were correctly drawn. Results: A total of 38 patients charts were reviewed (114 scans). The inner limiting membrane was correctly drawn by the segmentation software in 114/114 spectral domain OCT scans (100%). Conversely, Bruch’s membrane was correctly drawn in 59/114 scans (51.8%). The software was less reliable in locating Bruch’s membrane in case of pigment epithelium detachment (PED) than without PED (42.5 vs. 73.5%, respectively; p = 0.049), but its reliability was not associated with SRF or CME (p = 0.55 and p = 0.10, respectively). Conclusion: Segmentation of the inner limiting membrane was constantly trustworthy but Bruch’s membrane segmentation was poorly reliable using the automatic Spectralis segmentation software. Based on this software, evaluation of retinal thickness may be incorrect, particularly in case of PED. PED is effectively an important parameter which is not included when measuring retinal thickness.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Assessment of a Spectral Domain OCT Segmentation Software in a Retrospective Cohort Study of Exudative AMD Patients

Tilleul

Querques²,

Canouï‐Poitrine³

et al. 2012

Ophthalmologica

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“…Various studies compare the performances of RT analysis between TD-OCT systems and SD-OCT systems with each other [11,12], whereas studies evaluating the RT measurements obtained by SD-OCT devices from different manufacturers are still rare [13][14][15].…”

Section: Conflicts Of Interestmentioning

confidence: 99%

Cirrus OCT versus Spectralis OCT: differences in segmentation in fibrovascular pigment epithelial detachment

Smretschnig

Krebs

Moussa

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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“…According to our data, the correcting factor should be 1.48 to extrapolate CMT measurements from Stratus TD-OCT to Spectralis SD-OCT, 1.25 from Stratus TD-OCT to Cirrus SD-OCT and 1.18 from Cirrus SD-OCT to Spectralis SD-OCT. In previous studies a correction factor of 1.1 was suggested to extrapolate CMT values from Stratus SD-OCT to Spectral OCT/scanning laser ophthalmoscopy [16] , and Spectralis SD-OCT and Cirrus SD-OCT produced the highest CMT measurements when compared to the other commercially available SD-OCT devices [17,18] .…”

Section: Discussionmentioning

confidence: 99%

Spectral-Domain versus Time Domain Optical Coherence Tomography before and after Ranibizumab for Age-Related Macular Degeneration

Querques

Forte²,

Berboucha³

et al. 2011

Ophthalmic Res

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Purpose: To study the ability to appreciate qualitative features that indicate disease activity in patients with neovascular age-related macular degeneration (AMD) and to analyze the differences in automated retinal thickness measurement, using 1 time domain optical coherence tomography (TD-OCT) and 2 different spectral-domain OCT (SD-OCT) machines. Methods: Thirty-three consecutive naïve patients with neovascular AMD underwent Stratus TD-OCT, Cirrus SD-OCT and Spectralis SD-OCT, at baseline, 1 h, 1 day, 1 week and 1 month after intravitreal ranibizumab injection. Results: As regards the ability to detect retinal cysts, subretinal fluid and pigment epithelium detachment, at each follow-up visit, there was a significant correlation among all 3 OCT devices (p < 0.05), even though Cirrus SD-OCT and Spectralis SD-OCT showed the highest level of intermachine agreement. At each follow-up visit, automated retinal thickness measurements showed a greater mean central macular thickness (CMT) for both Spectralis SD-OCT and Cirrus SD-OCT, compared with Stratus TD-OCT. However, the mean paired differences in CMT among the 3 OCT devices were not statistically significant (p > 0.05). Overall, Cirrus SD-CT showed fewer segmentation errors, compared with both Spectralis SD-OCT and Stratus TD-OCT. Conclusion: SD-OCT showed a greater ability to evaluate qualitative features indicating disease activity and fewer errors in automated segmentation. However, differences in CMT changes were similar between TD-OCT and SD-OCT systems during follow-up.

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Quality of the Threshold Algorithm in Age-Related Macular Degeneration: Stratus versus Cirrus OCT

Cited by 32 publications

References 19 publications

Assessment of a Spectral Domain OCT Segmentation Software in a Retrospective Cohort Study of Exudative AMD Patients

Assessment of a Spectral Domain OCT Segmentation Software in a Retrospective Cohort Study of Exudative AMD Patients

Cirrus OCT versus Spectralis OCT: differences in segmentation in fibrovascular pigment epithelial detachment

Spectral-Domain versus Time Domain Optical Coherence Tomography before and after Ranibizumab for Age-Related Macular Degeneration

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