Quality of Twelve Clarithromycin Dry Syrup Formulations-Bitterness, Grittiness and Uniformity of Drug Loading

Ishizaka, Toshihiko; Okada, S; Tokuyama, Emi; Mukai, Junji; Uchida, Takahiro

doi:10.1248/cpb.56.1389

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…In addition, a study evaluating the clinical effect and safety of these formulations was performed in parallel [30].…”

Section: Methodsmentioning

confidence: 99%

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Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children

Mdsg¹,

Garruti²,

Laa³

et al. 2016

J Pharma Care Health Sys

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Many pediatric patients require medications that are not available in age appropriate formulations, especially those with cardiovascular diseases. The use of a suitable vehicle is critical for the preparation of extemporaneous formulations with the expected effect. Considering that palatability is essential to treatment adherence in children, we analyzed the acceptance of extemporaneous formulations of Captopril and Furosemide prepared using a developed vehicle in three flavors: neutral, strawberry and mint. Formulations were administered to hospitalized pediatric patients as prescribed. Acceptance was evaluated through the guardians using the hedonic scale and compared with the researcher's observation. Formulations in neutral and strawberry flavors were considered acceptable for both drugs. Correlation between results from both methods was moderate for Captopril and absent for Furosemide. Neutral taste results showed that the addition of flavoring agents did not improve acceptance. Since it is recommended to avoid components in formulations for infants and newborns, unless strictly necessary, it is important to identify excipients that are dispensable.

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“…In addition, a study evaluating the clinical effect and safety of these formulations was performed in parallel [30].…”

Section: Methodsmentioning

confidence: 99%

“…Sensory analysis is a stage of product development that analyzes and interprets the reactions produced by its features. Ideally should be performed whenever a new formulation is introduced in a given context [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children

Mdsg¹,

Garruti²,

Laa³

et al. 2016

J Pharma Care Health Sys

View full text Add to dashboard Cite

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Taste evaluation of a novel midazolam tablet for pediatric patients: In vitro drug dissolution, in vivo animal taste aversion and clinical taste perception profiles

Cheung

Nguyen

Tang

et al. 2018

International Journal of Pharmaceutics

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Harmonized methodologies are urgently required for the taste evaluation of novel pediatric medicines. This study utilized in vitro, in vivo and clinical data to evaluate the palatability of a novel midazolam chocolate tablet. In vitro dissolution experiments showed the crushed tablet to release within 5 min 1.68 mg of midazolam into simulated saliva. This translated to a drug level of 0.84 mg/ml in the oral cavity, which would be higher than the midazolam bitterness detection threshold concentration of 0.03 mg/ml determined in a rat 'brief access taste aversion' (BATA) model. The visual analogue scale scores of patients aged 4-16 years prescribed with midazolam pre-surgery showed a clear preference for the midazolam chocolate tablets (3.35 ± 1.04, n = 20) compared to the control midazolam solution (1.47 ± 0.62, n = 17). The clinical data was in agreement with the in vivo rodent data in showing the novel chocolate tablet matrix to be effective at taste-masking the bitter midazolam.

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Preparation and Evaluation of Clarithromycin Taste-Masking Dry Suspension Using Hot Melt Extrusion Based on Solid Dispersion Technology

Zhang,

Yu,

Fan

et al. 2024

Chem. Pharm. Bull.

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Quality of Twelve Clarithromycin Dry Syrup Formulations-Bitterness, Grittiness and Uniformity of Drug Loading

Abstract: Left: before suspension in water; centre: after 30 s suspension; right: after 5 min suspension.

Cited by 4 publications

References 11 publications

Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children

Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children

Taste evaluation of a novel midazolam tablet for pediatric patients: In vitro drug dissolution, in vivo animal taste aversion and clinical taste perception profiles

Preparation and Evaluation of Clarithromycin Taste-Masking Dry Suspension Using Hot Melt Extrusion Based on Solid Dispersion Technology

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