Quality of Well-being profiles followed paths of health status change at micro- and meso-levels in trauma patients

Anderson, John P.; Holbrook, Troy L.

doi:10.1016/j.jclinepi.2006.06.003

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Although conflicting results are found in the literature about variation of QOL over time, 41,35,42 our results revealed that QOL is still decreased after the rehabilitation phase (1-5 years after the accident). This observation is in agreement with the results found at long periods after cerebral lesions by Teasdale and Engberg.…”

Section: Discussioncontrasting

confidence: 56%

Quality of life in severely injured patients depends on psychosocial factors rather than on severity or type of injury

Delft-Schreurs¹,

Bergen

Jongh³

et al. 2014

Injury

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Section: Discussioncontrasting

confidence: 56%

Quality of life in severely injured patients depends on psychosocial factors rather than on severity or type of injury

Delft-Schreurs¹,

Bergen

Jongh³

et al. 2014

Injury

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“…und Wiederherstellungschirurgie der Universit ä t Ulm § BG-Unfallklinik (gleichzeitig Klinik f ü r Unfallchirurgie der Eberhard-Karls-Universit ä t) T ü bingen Die Rehaeinrichtungen waren § BG-Unfallklinik, Abteilung f ü r Rehabilitation (gleichzeitig Klinik f ü r Unfallchirurgie der Eberhard-Karls-Universit ä t) T übingen § Universit ä tsrehabilitationsklinik der Universit ä t Ulm, Rheuma klinik Bad Wurzach § Rehabilitationsklinik Bad Saulgau. Untersucht wurde der Reha-Erfolg nach traumatologischen Krankheitsbildern, die typischerweise eine operative Therapie erfordern und die besonders h ä ufi g mit langer Arbeitsunf ä higkeit und Invalidisierung behaftet sind [1,8,10,11,14] . Ferner wurden f ü r die Wirbels ä ulenverletzten als gr ö ß te Probandengruppe der VAS-Wirbels ä ulenscore [9] der DGU eingesetzt.…”

Section: Die Akutkliniken Waren § Zentrum F ü R Chirurgie Klinik F üunclassified

Wiedererlangung der Arbeitsfähigkeit nach Trauma – ist der Zeitpunkt der Rehabilitation entscheidend?

Einsiedel¹,

Sorg²,

Hartwig³

et al. 2008

Phys Rehab Kur Med

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The Prion Hypothesis of Parkinson’s Disease

Chu

Kordower

2015

Curr Neurol Neurosci Rep

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The discovery of alpha-synuclein's prion-like behaviors in mammals, as well as a non-Mendelian type of inheritance, has led to a new concept in biology, the "prion hypothesis" of Parkinson's disease. The misfolding and aggregation of alpha-synuclein (α-syn) within the nervous system occur in many neurodegenerative diseases including Parkinson's disease (PD), Lewy body dementia (LBD), and multiple system atrophy (MSA). The molecular basis of synucleinopathies appears to be tightly coupled to α-syn's conformational conversion and fibril formation. The pathological form of α-syn consists of oligomers and fibrils with rich in β-sheets. The conversion of its α-helical structure to the β-sheet rich fibril is a defining pathologic feature of α-syn. These kinds of disorders have been classified as protein misfolding diseases or proteopathies which share key biophysical and biochemical characteristics with prion diseases. In this review, we highlight α-syn's prion-like activities in PD and PD models, describe the idea of a prion-like mechanism contributing to PD pathology, and discuss several key molecules that can modulate the α-syn accumulation and propagation.

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Quality of Well-being profiles followed paths of health status change at micro- and meso-levels in trauma patients

Cited by 5 publications

References 35 publications

Quality of life in severely injured patients depends on psychosocial factors rather than on severity or type of injury

Quality of life in severely injured patients depends on psychosocial factors rather than on severity or type of injury

Wiedererlangung der Arbeitsfähigkeit nach Trauma – ist der Zeitpunkt der Rehabilitation entscheidend?

The Prion Hypothesis of Parkinson’s Disease

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