Quality standard of traditional Chinese medicines: comparison between European Pharmacopoeia and Chinese Pharmacopoeia and recent advances

Leong, Fong; Xue, Hua; Wang, Mei; Chen, Tongkai; Song, Yuelin; Tu, Pengfei; Chen, Xiao‐Jia

doi:10.1186/s13020-020-00357-3

Cited by 76 publications

(32 citation statements)

References 76 publications

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“…Finally, D. officinale possesses various biological activities, which has been applied as health care medicine, health food, and health tea. In addition, with the development of analytical techniques and quality control methods, such as the improvement and update in chromatography techniques and molecular identification methods, new quality markers and quality control measures are likely to be adopted for better quality assessment of Chinese herbal medicine in the future (Leong et al, 2020).…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Wen-hua

Zhang

et al. 2021

Front. Pharmacol.

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Dendrobium officinale, a well-known plant used as a medicinal and food homologous product, has been reported to contain various bioactive components, such as polysaccharides, bibenzyls, phenanthrenes, and flavonoids. It is also widely used as a traditional medicine to strengthen “Yin”, nourish heart, tonify five viscera, remove arthralgia, relieve fatigue, thicken stomach, lighten body, and prolong life span. These traditional applications are in consistent with modern pharmacological studies, which have demonstrated that D. officinale exhibits various biological functions, such as cardioprotective, anti-tumor, gastrointestinal protective, anti-diabetes, immunomodulatory, anti-aging, and anti-osteoporosis effects. In this review, we summarize the research progress of D. officinale from November 2016 to May 2021 and aim to better understand the botany, traditional use, phytochemistry, and pharmacology of D. officinale, as well as its quality control and safety. This work presents the development status of D. officinale, analyzes gaps in the current research on D. officinale, and raises the corresponding solutions to provide references and potential directions for further studies of D. officinale.

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Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Wen-hua

Zhang

et al. 2021

Front. Pharmacol.

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“…In the progress of modernization and globalization of HMs, the crux is their quality consistency and controllability 1,2 . Herbal medicine technology is used for converting botanicals materials into HMs, where standardization and quality control with proper integration of modern scienti c techniques and traditional knowledge, which is essential for realizing consistency and controllability of product quality 3 . However, quality control of HMs still faces a great challenge because their chemical composition is very complex and chemical changes take place during their production processes 4,5 .…”

Section: Introductionmentioning

confidence: 99%

“…In each equation, the regression coe cients displayed are computed for centered and orthogonal scaled data 2. The variable which had a large coe cient with a small p value (< 0.05) was considered to show signi cant in uence and would be reserved in the equation, and the other would be deleted 3. Linear term could not be deleted if the second and third order terms involving the factor having signi cance.…”

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confidence: 99%

Process characterization for ethanol precipitation of Salviae Miltiorrhizae Radix et Rhizoma using 1H NMR spectroscopy and chemometrics

Zhao

Pan

et al. 2020

Preprint

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Background Quality control of the herbal medicines (HMs) still hits technical bottlenecks due to their complicated multi-step pharmaceutical processes. Nuclear magnetic resonance (NMR) spectroscopy could serve as a powerful technique able to obtain comprehensive information of chemical compounds in the manufacturing process of HMs by a single analytical test. In this study, ethanol precipitation of Salvia miltiorrhiza Radix et Rhizoma (Danshen in China), a critical purification process of a particularly commonly used herbal medicinal material, was employed as the research subject. Methods Processed with different variables, including ethanol-material ratio, apparent ethanol concentration and moisture concentration of the raw material, 40 lab-scale experiments of ethanol precipitation were orchestrated by a full factor design with additional central composite circumscribed experiments. After 1H NMR tests, chemometrics methods, including orthogonal partial least squares-discriminant analysis (OPLS-DA), principle component analysis (PCA) and multiple linear regression (MLR), were applied to analyze the spectra of samples. Results 16 metabolites were recognized as the most critical potential chemical markers in the process of Danshen ethanol precipitation by 1H NMR spectra and OPLS-DA, including γ-aminobutyrate, pyroglutamate, succinate, acetate, malonate, fructose, sucrose, raffinose, stachyose, mannotriose, danshensu, lithospermic acid, protocatechuic aldehyde, rosmarinic acid, salvianolic acid A and B. PCA reasonably distinguished all the process intermediates as a function of different process variables adopted during the ethanol precipitation. MLR made the statistical interpretation by quadratic equations to characterize how do significant variables affect the chemical markers. Conclusions Our study indicates that NMR can track detailed potential chemical markers of ethanol precipitation process, which could promote the further understanding of ethanol precipitation process and open up possibilities to develop a more effective process quality control and consistency evaluation methodology of an HM, through providing a more in-depth and improved theoretical process understanding and characterization.

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“…According to Chinese Pharmacopoeia (2020), a total collection contains 2711 types of herbs, and varieties that have undergone systematic chemical composition studies do not exceed 20 %. This phenomenon is one of the reasons why TCM is difficult to be accepted in foreign countries [ 49 ].…”

Section: Challenges Of Tcm Development In Pscmentioning

confidence: 99%

The internationalization of TCM towards Portuguese-speaking countries

et al. 2021

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With the increasing demand for traditional Chinese medicine (TCM) in Portuguese-speaking countries (PSC), local regulatory systems and relevant legislation are still insufficient and lagging, even blank in some of them. This kind of unbalanced pace either makes users of TCM exposed in potential risk or eventually obstructs the long-term development of TCM in PSC. Despite existing tremendous studies on the internationalization of TCM, there are few studies specific to PSC. Thus, by a comprehensive desk review and typical case study, this article aims to summarize current situation of TCM in PSC by a cross-regional comparison, to identify various critical challenges, and further to provide an insightful reference to impel the development of TCM in PSC.

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Quality standard of traditional Chinese medicines: comparison between European Pharmacopoeia and Chinese Pharmacopoeia and recent advances

Cited by 76 publications

References 76 publications

Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Process characterization for ethanol precipitation of Salviae Miltiorrhizae Radix et Rhizoma using 1H NMR spectroscopy and chemometrics

The internationalization of TCM towards Portuguese-speaking countries

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