Quality test of metoprolol tartrate tablets.

Abstract

In the quality test of 2 brands of film coated tablets containing 20mg of metoprolol tartrate, their dissolution, weight variation, content uniformity, disintegration and hardness were studied. Their weight variation was 0.8 to 1.9%, content 20.1 to 20.4mg, and disintegration time less than 10.8 min, all meeting the JP X requirements.The hardness was 5.7 to 6.3 kg/ cm2. In the dissolution test with use of the 1st fluid (Disintegration Test, JP X) by rotatory basket method, 50 and 90% dissolution times (T50 and T90) of the 2 brands were almost the same, while the results obtained by the paddle method were not so different from those by rotatory basket method. In addition, the effect of pH on Tiso and Too was studied. Too and To of 2 brands were influenced slightly by pH of dissolution fluid. No other significant differences were observed between 2 brands.