2021
DOI: 10.1007/s11419-021-00584-9
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Quantification and distribution of 4-fluoroisobutyryl fentanyl (4-FiBF) in postmortem biological samples using UHPLC–QqQ-MS/MS

Abstract: Purpose Development of ultra-high-performance liquid chromatography-triple quadrupole tandem mass spectrometry method for quantification of 4-fluoroisobutyryl fentanyl (4-FiBF) and its distribution in postmortem biological samples in four fatal intoxication cases, which occurred in September 2018, in Poland. Methods Biological fluids (blood, urine, vitreous humor, bile, gastric content) and tissues (brain, kidney, liver, stomach wall) were extracted with e… Show more

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Cited by 16 publications
(4 citation statements)
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“…Within these effects prevail paranoia, hallucinations, agitation, and unconsciousness. Moreover, cardiac effects can be present, such as tachycardia, vasoconstriction and cardiac arrest, muscular effects such as tremors and rhabdomyolysis, or even death, as in the fatal cases mentioned above [24,25,33,34,83]. Comparing the effects on behaviour of α-PiHP and α-PHP administration, it can be deduced that both have very similar locomotor stimulant and discriminative stimulus effects [89,93,94].…”
Section: Adverse Effectsmentioning
confidence: 97%
See 1 more Smart Citation
“…Within these effects prevail paranoia, hallucinations, agitation, and unconsciousness. Moreover, cardiac effects can be present, such as tachycardia, vasoconstriction and cardiac arrest, muscular effects such as tremors and rhabdomyolysis, or even death, as in the fatal cases mentioned above [24,25,33,34,83]. Comparing the effects on behaviour of α-PiHP and α-PHP administration, it can be deduced that both have very similar locomotor stimulant and discriminative stimulus effects [89,93,94].…”
Section: Adverse Effectsmentioning
confidence: 97%
“…Like α-PHP, this substance can be found in solid crystal and powder forms. Alpha-PiHP hydrochloride, in its pure form, tends to be odourless and can vary from off-white to white [25,34,[80][81][82][83][84]. This substance has been sold on the streets under its original name and the same name as synthetic cathinones and has already been reported in a branded product called "Insomnia" [25].…”
Section: Identificationmentioning
confidence: 99%
“…Publications describing methods of analysis for individual fentanyl analogs [23][24][25][26] and multiple fentanyl analogs in addition to fentanyl [27][28][29][30][31][32] all use LCMSMS and these studies provide a great starting point for laboratories introducing LCMSMS for the first time and/or developing new methods. In postmortem cases, only tissues are available due to decomposition, and there are several publications exploring the distribution of fentanyl and its analogs in different tissues including the method parameters used [13,[33][34][35][36][37].…”
Section: Analytical Challengesmentioning
confidence: 99%
“…In Italy, methoxyacetylfentanyl were found in postmortem blood (2.5–91 ng/ml) and urine (70–1900 ng/ml), along with its metabolite methoxyacetylnorfentanyl and other synthetic opioids ( DiTrana et al, 2020 ) ( Table 1 and Supplementary Table S1 ). Other studies also described blood concentrations of fentanyl derivatives, including ocfentanil (15.3 ng/ml; Coopman et al, 2016 ), butyryl fentanyl (99–220 ng/ml; Poklis et al, 2016 ), 4-fluorobutyrylfentanyl (91–112 ng/ml; Rojkiewicz et al, 2016 ) and 4-fluoroisobutyryl fentanyl (76.1–257 ng/ml), in addition to synthetic cathinones (N-ethylpentylone, α-PiHP and 4-CMC; Zawadzki et al, 2021 ).…”
Section: Fatal Cases Involving New Psychoactive Substance Intakementioning
confidence: 99%