Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection

Ward, Scott M.; Fox, Bridget; Brown, Philip J.; Worthington, J.; Fox, Stephen B.; Chapman, Roger W.; Fleming, K. A.; Banham, Alison H.; Klenerman, Paul

doi:10.1016/j.jhep.2007.03.023

Cited by 136 publications

(134 citation statements)

References 42 publications

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“…Our findings are consistent with the study of Ward et al (16) in the idea that the main effect of the Treg presence and activa- A B tion within the liver parenchyma during HCV infection leads to a relative reduction in liver inflammation while the Treg presence may favour fibrogenesis by the production of TGF-β. However, since the correlation with fibrosis still remains unclear, analysis of the TGF-β distribution pattern in relation to the presence of Foxp3…”

supporting

confidence: 93%

Evaluation of circulating CD4+CD25+ and liver-infiltrating Foxp3+ cells in HCV-associated liver disease

et al. 2012

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Abstract. In hepatitis C virus (HCV)-associated liver disease, the immune system is unable to clear the viral infection. Previous studies have raised the possibility of an involvement of regulatory T cells (Tregs) + cells in the liver infiltrates showed significantly higher proportions of peripheral CD4 + CD25 low cells. Moreover, we found lower serum transaminase levels in the patients than in the controls, as shown by Foxp3 + immunohistochemistry, although these results were only statistically significant as regards alanine transaminase (ALT). In conclusion, these data suggest that the presence of Tregs infiltrating the liver is associated with high levels of activated/effector T cells in the peripheral blood and lower activity of hepatitis. Therefore, liver-infiltrating Tregs may play a role in limiting tissue damage and may thus support an effective immune response against HCV.

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supporting

confidence: 93%

Evaluation of circulating CD4+CD25+ and liver-infiltrating Foxp3+ cells in HCV-associated liver disease

et al. 2012

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“…In addition, intrahepatic Foxp3 + cells correlated with the clinical consequences of the immune suppression, demonstrated by the rise of plasma viremia ( Figure 3F) and the decline of hepatic damage ( Figure 3G), as calculated by the histological activity index (HAI) score (53). This finding is clearly different from a previous immune histochemistry description showing that increased inflammation directly correlated with increased Tregs in the liver (54). This disparity is likely attributable to the different systems used.…”

Section: Accumulation and Proliferation Of Tregs And Teffs In Hcv-infmentioning

confidence: 58%

PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

et al. 2009

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“…Similarly, the magnitude of the CD4+ T cell response in the liver appears to be inversely proportional to the degree of liver injury [181]. Although most investigators have approached Treg as a potential factor in mediating chronicity, a recent study demonstrated that CD4+CD25+ Treg may have an inverse relationship to liver inflammation [182]. Therefore, CD4+ responses in general appear to be protective in the setting of chronic infection, even if they do not completely prevent disease.…”

Section: Immune Responses In Chronic Infection: Friend or Foe?mentioning

confidence: 99%

Immune responses during acute and chronic infection with hepatitis C virus

Ishii

Koziel

2008

Clinical Immunology

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Hepatitis C virus (HCV) induces persistent infection and causes chronic liver disease in most infected patients. Vigorous HCV-specific CD4+ and CD8+ T cell responses against HCV multiple epitopes are necessary for spontaneous viral clearance during the acute phase, but the virus appears to have multiple strategies to evade these defenses. There are relatively few studies on the role of immune responses during the chronic phase of infection. CD4+ T cell responses appear to protect against liver injury and may be important to clearance during interferon and ribavirin based therapy. Classic cytotoxic T cells (CTL) may primarily damage the liver in chronic HCV, but there may be subpopulations of T cells that protect against liver inflammation. Resolution of these outstanding questions is important to the development of a prophylactic vaccine as well as improving therapeutic options for those with chronic infection.

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Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection

Cited by 136 publications

References 42 publications

Evaluation of circulating CD4+CD25+ and liver-infiltrating Foxp3+ cells in HCV-associated liver disease

Evaluation of circulating CD4+CD25+ and liver-infiltrating Foxp3+ cells in HCV-associated liver disease

PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

Immune responses during acute and chronic infection with hepatitis C virus

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