Quantification of Anticoagulants Dabigatran, Rivaroxaban, and Prasugrel by Chromatographic and Spectrometric Techniques – Review

B, Satya Prasad; Jayakumari, S.

doi:10.22159/ajpcr.2019.v12i4.29954

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Siklus menstruasi dan pubertas menjadi penyebab jerawat pada kalangan remaja, karena peningkatan kadar androgen menyebabkan pembesaran kelenjar folikel dan peningkatan produksi sebum melebihi jumlah yang dibutuhkan kulit sehingga menimbulkan jerawat. Peningkatan produksi sebum disebabkan karena perubahan hormon pada masa pubertas (Handayani et al, 2013) (Prasad, 2016).…”

Section: Pendahuluanunclassified

UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN PALA (Myristica fragrans Houtt) TERHADAP Staphylococcus epidermidis

Wisdyafanny,

Silviani

2023

Farmasi.J

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Acne vulgaris atau jerawat dapat disebabkan oleh bakteri, salah satunya Staphylococcus epidermidis yang akan menghasilkan enzim lipolitik yang mengubah sebum menjadi massa padat, kemudian akan menyumbat saluran kelenjar sebasea. Daun pala mengandung senyawa saponin, triterpenoid, tanin, dan flavonoid sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui daya hambat ekstrak etanol daun pala (Myristica fragrans Houtt) terhadap pertumbuhan Staphylococcus epidermidis. Penelitian ini menggunakan metode penelitian deskriptif eksperimental untuk mengetahui efektivitas antibakteri ekstrak etanol daun pala (Myristica fragrans Houtt) terhadap Staphylococcus epidermidis. Sumber data penelitian ini adalah data primer yaitu berdasarkan hasil zona hambat terhadap Staphylococcus epidermidis dengan pemberian ekstrak etanol daun pala (Myristica fragrans Houtt) dengan konsentrasi 20%, 40%, 60%, 80%, dan 100%. Hasil penelitian menunjukkan bahwa ekstrak etanol daun pala dapat digunakan sebagai antibakteri terhadap Staphylococcus epidermidis. Rata-rata diameter zona hambat ekstrak daun pala yang terbentuk pada konsentransi 20% yaitu sebesar 10,45 mm, pada konsentrasi 40% yaitu sebesar 11,4 mm, pada konsentrasi 60% yaitu sebesar 11,9 mm, pada konsentrasi 80% yaitu sebesar 12,35 mm, dan pada konsentrasi 100% yaitu sebesar 12,6 mm. Konsentrasi 100% mampu menghambat Staphylococcus epidermidis dengan rata-rata diameter zona hambat paling luas yaitu sebesar 12,6 mm.

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Section: Pendahuluanunclassified

UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN PALA (Myristica fragrans Houtt) TERHADAP Staphylococcus epidermidis

Wisdyafanny,

Silviani

2023

Farmasi.J

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Bioanalytical RP-HPLC Method for Simultaneous Quantification of Rivaroxaban and Ticagrelor in Spiked Human Plasma: Validation and Stability

Eswarudu

Rao²,

Kotra

2023

RJPT

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For the effective assessment of preclinical, biopharmaceutical and clinical pharmacological investigations, selective and sensitive analytical methods for the quantitative evaluation of drugs and their metabolites (analytes) are essential. Using Rilpivirine as an internal standard (IS), a simple, fast, sensitive, precise and accurate high performance liquid chromatographic method for simultaneous determination of Rivaroxaban and Ticagrelor in human plasma was developed. The analytes were extracted using a direct protein precipitation method with acetonitrile from 500μL aliquots of human plasma. The content of the drugs was assessed using a mobile phase consisting of acetonitrile and 0.1% orthophosphoric acid buffer in a 40:60 v/v ratio and with a flow rate of 1.0ml/min, and an injection volume of 10μL. A Kromasil C18 (250×4.6mm; 5µm) analytical column was used for chromatographic separation and the effluents were monitored at 265nm using a photo diode array (PDA) detector.Rivaroxaban, Ticagrelor and Rilpivirine had retention times of 4.716min, 6.396min and 5.405 min, respectively. Rivaroxaban was shown to be linear at concentrations ranging from 0.018µg/mL - 1.80µg/mL, whereas Ticagrelor was found to be linear between 0.020µg/Ml - 2.00µg/mL. The method was validated according to US-FDA guidelines, and the findings satisfied the acceptance criteria. It was successfully used to determine Rivaroxaban and Ticagrelor in human plasma at the same time and this method is applicable for the pre-clinical and clinical estimation of drugs in biological fluids.

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Quantification of Anticoagulants Dabigatran, Rivaroxaban, and Prasugrel by Chromatographic and Spectrometric Techniques – Review

Cited by 2 publications

References 22 publications

UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN PALA (Myristica fragrans Houtt) TERHADAP Staphylococcus epidermidis

UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN PALA (Myristica fragrans Houtt) TERHADAP Staphylococcus epidermidis

Bioanalytical RP-HPLC Method for Simultaneous Quantification of Rivaroxaban and Ticagrelor in Spiked Human Plasma: Validation and Stability

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