Quantification of autonomic regulation in patients with sudden sensorineural hearing loss

Schulz, Steffen; Ritter, Julia; Oertel, Katrin; Witt, Katharina; Bär, Karl‐Jürgen; Guntinas‐Lichius, Orlando; Voss, Andreas

doi:10.1016/j.autneu.2013.02.009

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…In contrast to these findings, we found in our previous study (10) where ISSHL patients were compared with healthy, age-and sex-matched, normal-hearing control subjects no significant difference between groups applying HRV analysis. Comparable results were found by Ucar et al (28) who investigated children with congenital sensorineural deafness and compared those healthy children applying standard HRV analysis in the time and frequency domains and found also no significant differences in HRV indices between both groups.…”

Section: Discussioncontrasting

confidence: 99%

“…Both HRJSD combinations were considerably reduced in ISSHL and increased in CON ( Table 4). Similar results of reduced BP variability was found when ISSHL patients where compared with normal-hearing healthy controls (10). It seems to be that these specific cardiovascular coupling patterns in ISSHL are characterized by a less pronounced strong and fast decrease of systolic BP when HR increases (LD1) and rapidly changes (P), pointing to a much more impaired baroreflex mechanism in those patients as in CON.…”

Section: Discussionsupporting

confidence: 74%

“…The results on the association with hypertension are contradictory (5). In addition, we could demonstrate that ISSHL patients have an altered and increased short-term nonlinear cardiovascular coupling, supporting the theory of vascular involvement in the etiology (10). A growing number of studies demonstrate an association between autonomic nervous system (sympathetic and parasympathetic) dysfunction and risk of cardiovascular diseases such as myocardial infarction, sudden death, or stroke (7,8).…”

mentioning

confidence: 69%

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Altered Autonomic Regulation as a Cardiovascular Risk Marker for Patients With Sudden Sensorineural Hearing Loss

Schulz¹,

Ritter

Oertel³

et al. 2014

Otology &Amp; Neurotology

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 74%

mentioning

confidence: 69%

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Altered Autonomic Regulation as a Cardiovascular Risk Marker for Patients With Sudden Sensorineural Hearing Loss

Schulz¹,

Ritter

Oertel³

et al. 2014

Otology &Amp; Neurotology

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“…Several studies have suggested a role of the ANS in the etiology of SSNHL by measuring HRV and blood pressure variability. A study by Schulz and colleagues revealed reduced variability, complexity, and dynamics of blood pressure time-series data in patients with SSNHL compared to those in healthy controls, reflecting the inhibition of both sympathetic and parasympathetic modulation [Schulz et al, 2013]. Demirelli and colleagues reported elevated blood pressure at night and reduced HRV, suggesting autonomic dysfunction in patients with SSNHL [Demirelli et al, 2016].…”

Section: Discussionmentioning

confidence: 99%

Autonomic Nervous Function in Patients with Sudden Sensorineural Hearing Loss and Its Association with Prognosis and Disease Severity

2021

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Introduction: Vascular disorder is considered one of the main mechanisms of sudden sensorineural hearing loss (SSNHL) due to the anatomy of the inner ear. One factor that can contribute to vascular disorder is impairment in the autonomic nervous system. This study aims to investigate autonomic function in patients with SSNHL and its association with prognosis and disease severity from January 2018 to October 2019. Methods: We conducted a cross-sectional study involving 40 healthy controls and 55 subjects with SSNHL. We compared the autonomic function of controls and patients using heart rate variability (HRV). SSNHL patients were divided into improvement and no-improvement groups and into mild and severe groups according to pure-tone audiometry results. Results: The SSNHL group had significantly decreased total power (TP), low frequency (LF), and high frequency (HF) compared to the control group. However, there were no significant differences between the mild and severe groups. In the no-improvement group, LF was significantly higher and normalized HF was significantly lower than in the improvement group. According to a multiple logistic regression analysis, age and LF were significantly correlated with improvement. Conclusion: This is the first study to evaluate the significance of HRV in patients with SSNHL, according to prognosis and disease severity. Further studies about the relationship between autonomic nervous system and SSNHL with larger sample size and prospective design are needed.

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“…Dysrhythmia not only leads to systemic hemodynamic instability but also is associated with increased risks of thromboembolism and atherosclerosis, both of which have been reported to be related to SSNHL and chronic hearing impairment [20–26]. Previous studies have also found that patients with SSNHL exhibit autonomic alterations presenting as dysregulation in heart rhythm and blood pressure [27–29].…”

Section: Introductionmentioning

confidence: 99%

Risk of sudden sensorineural hearing loss in patients with dysrhythmia: A nationwide population-based cohort study

et al. 2019

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Objective Whether dysrhythmia is a risk factor of sudden sensorineural hearing loss (SSNHL) remains unclear. In this study, we aimed to investigate the risk of developing SSNHL among patients with dysrhythmia in different age and gender groups by using population-based data in Taiwan. Methods We conducted a matched cohort study by analyzing data between January 2000 and December 2013 obtained from the Taiwan National Health Insurance Research Database. 41,842 newly diagnosed dysrhythmia patients and 83,684 comparison subjects without dysrhythmia were selected from claims. The incidence of sudden sensorineural hearing loss at the end of 2013 was determined in both groups. Univariate and multivariate logistic regression analyses were used to investigate the risk of SSNHL among patients with dysrhythmia. Results The incidence of SSNHL was 1.30-fold higher in the dysrhythmia group compared with the control group (53.2 versus 40.9 per 100,000 person-years), and using Cox proportional hazard regressions, the adjusted hazard ratio (HR) was 1.40 (95% confidence interval [CI], 1.15–1.70). Gender-stratified analysis revealed a significantly higher risk of SSNHL in patients with dysrhythmia than in those without dysrhythmia for both men and women (HR = 1.34, 95% CI = 1.02–1.76, P = 0.039, HR = 1.35, 95% CI = 1.02–1.78, P = 0.035, respectively). Age-stratified analysis revealed remarkable associations between dysrhythmia and SSNHL among those aged less than 40 years and more than 65 years (HR = 2.18, 95% CI = 1.03–4.64, P = 0.043 and HR = 1.54, 95% CI = 1.14–2.09, P = 0.006, respectively). Conclusions Our findings support dysrhythmia as an independent risk factor for SSNHL. Based on the study results, clinicians managing patients with dysrhythmia should be aware of the increased risk of developing SSNHL, especially among patients aged <40 and >65 years, and counsel patients to seek medical advice immediately if they experience any acute change in their hearing ability.

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Quantification of autonomic regulation in patients with sudden sensorineural hearing loss

Cited by 7 publications

References 32 publications

Altered Autonomic Regulation as a Cardiovascular Risk Marker for Patients With Sudden Sensorineural Hearing Loss

Altered Autonomic Regulation as a Cardiovascular Risk Marker for Patients With Sudden Sensorineural Hearing Loss

Autonomic Nervous Function in Patients with Sudden Sensorineural Hearing Loss and Its Association with Prognosis and Disease Severity

Risk of sudden sensorineural hearing loss in patients with dysrhythmia: A nationwide population-based cohort study

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