Quantification of beta-galactosidase activity as a marker of radiation-driven cellular senescence

Klapp, Vanessa; Bloy, Norma; Petroni, Giulia; Martino, Mara De

doi:10.1016/bs.mcb.2022.10.001

Methods in Cell Biology

2023

DOI: 10.1016/bs.mcb.2022.10.001

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Quantification of beta-galactosidase activity as a marker of radiation-driven cellular senescence

Vanessa Klapp¹,

Norma Bloy²,

Giulia Petroni³

et al.

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2024

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Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities

Olajide,

Oyerinde,

Omotosho

et al. 2024

Neuroprotection

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The existing literature on neurodegenerative diseases (NDDs) reveals a common pathological feature: the accumulation of misfolded proteins. However, the heterogeneity in disease onset mechanisms and the specific brain regions affected complicates the understanding of the diverse clinical manifestations of individual NDDs. Dementia, a hallmark symptom across various NDDs, serves as a multifaceted denominator, contributing to the clinical manifestations of these disorders. There is a compelling hypothesis that therapeutic strategies capable of mitigating misfolded protein accumulation and disrupting ongoing pathogenic processes may slow or even halt disease progression. Recent research has linked disease‐associated microglia to their transition into a senescent state—characterized by irreversible cell cycle arrest—in aging populations and NDDs. Although senescent microglia are consistently observed in NDDs, few studies have utilized animal models to explore their role in disease pathology. Emerging evidence from experimental rat models suggests that disease‐associated microglia exhibit characteristics of senescence, indicating that deeper exploration of microglial senescence could enhance our understanding of NDD pathogenesis and reveal novel therapeutic targets. This review underscores the importance of investigating microglial senescence and its potential contributions to the pathophysiology of NDDs, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Additionally, it highlights the potential of targeting microglial senescence through iron chelation and senolytic therapies as innovative approaches for treating age‐related NDDs.

show abstract

Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities

Olajide,

Oyerinde,

Omotosho

et al. 2024

Neuroprotection

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show abstract

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Quantification of beta-galactosidase activity as a marker of radiation-driven cellular senescence

Cited by 1 publication

References 63 publications

Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities

Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities

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