2022
DOI: 10.32598/bcn.2022.575.1
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Quantification of Blood-Brain-Barrier Permeability Dysregulation and Inflammatory Activity in MS Lesions by Dynamic-Contrast Enhanced MR Imaging

Abstract: Objective: Measurement of blood-brain permeability dysfunction in active and chronic MS lesions with T1-weighted dynamic contrast-enhanced MRI to show variation in inflammatory activity Background: blood-brain-barrier perfusion characterization impaired in MS as some studies have shown recently buta comparison between perfusion parameters in contrast-enhanced and non-enhanced lesions not have been well documented. Pharmacokinetic quantitative parameters have obtained from dynamic contrast-enhanced in magnetic … Show more

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Cited by 7 publications
(4 citation statements)
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“…K trans and K 2trans are parameters used in DCE‐MRI to measure the transfer of contrast agents from blood plasma to the extravascular extracellular space (EES). K trans represents the volume transfer constant between blood plasma and EES, while K 2trans is the volume transfer constant between the slow compartment and EES in the two‐tissue compartment model 91,92 . Some studies have investigated the use of PWI techniques for predicting treatment response and patient survival outcomes.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…K trans and K 2trans are parameters used in DCE‐MRI to measure the transfer of contrast agents from blood plasma to the extravascular extracellular space (EES). K trans represents the volume transfer constant between blood plasma and EES, while K 2trans is the volume transfer constant between the slow compartment and EES in the two‐tissue compartment model 91,92 . Some studies have investigated the use of PWI techniques for predicting treatment response and patient survival outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…K trans represents the volume transfer constant between blood plasma and EES, while K 2trans is the volume transfer constant between the slow compartment and EES in the two‐tissue compartment model. 91 , 92 Some studies have investigated the use of PWI techniques for predicting treatment response and patient survival outcomes. For example, a study found that lower K 2trans at 1 week and rCBV at 1 month can differentiate responders from progressive disease.…”
Section: Discussionmentioning
confidence: 99%
“…It takes into account the contribution of the vascular compartment which is not negligible in tumors. Several studies have used this model to describe variations in hemodynamic parameters (K trans , k ep , v e , and v p ) after the disruption of the BBB [35][36][37][38][39]. Here, however, we were unable to tackle any variation in these parameters using the extended Tofts model.…”
Section: Discussionmentioning
confidence: 99%
“…Контрастное вещество на основе трехвалентного гадолиния, относящееся к группе позитивных парамагнетиков, в норме не проникает через гематоэнцефалический барьер. Считается, что при РС оно проходит через стенки капилляров и на некоторое время задерживается во внеклеточном пространстве [22].…”
Section: критерии магнитно-резонансных проявлений поражений при рассе...unclassified