Quantification of C<sub>60</sub>-induced membrane disruption using a quartz crystal microbalance

Zeng, Yuxuan; Wang, Qi; Zhang, Qiu; Jiang, Wei

doi:10.1039/c7ra13690k

Cited by 13 publications

(5 citation statements)

References 69 publications

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“…Besides, positively charged CDs such as spermidine CDs can bind to peptidoglycans, proteins, and porins of the cell membrane through hydrogen bonding and electrostatic interactions, resulting in a synergistic destabilization of the cell membrane as well as in inhibition of membrane synthesis . Likewise, a remarkable membrane disruption was found to occur in giant unilamellar vesicles model systems following treatment with C 60 , which was detected using fluorescence imaging (Figure b) …”

Section: Antibacterial Mechanisms Of Cnmsmentioning

confidence: 95%

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Antibacterial Carbon‐Based Nanomaterials

et al. 2018

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201804838.The emergence and global spread of bacterial resistance to currently available antibiotics underscore the urgent need for new alternative antibacterial agents. Recent studies on the application of nanomaterials as antibacterial agents have demonstrated their great potential for management of infectious diseases. Among these antibacterial nanomaterials, carbon-based nanomaterials (CNMs) have attracted much attention due to their unique physicochemical properties and relatively higher biosafety. Here, a comprehensive review of the recent research progress on antibacterial CNMs is provided, starting with a brief description of the different kinds of CNMs with respect to their physicochemical characteristics. Then, a detailed introduction to the various mechanisms underlying antibacterial activity in these materials is given, including physical/mechanical damage, oxidative stress, photothermal/photocatalytic effect, lipid extraction, inhibition of bacterial metabolism, isolation by wrapping, and the synergistic effect when CNMs are used in combination with other antibacterial materials, followed by a summary of the influence of the physicochemical properties of CNMs on their antibacterial activity. Finally, the current challenges and an outlook for the development of more effective and safer antibacterial CNMs are discussed.

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Section: Antibacterial Mechanisms Of Cnmsmentioning

confidence: 95%

“…The formation of lipid agglomerates from disrupted GUVs is revealed by fluorescence imaging, indicating that C 60 adhesion causes lipid fragments to attach to each other. b) Reproduced with permission . Copyright 2018, The Royal Society of Chemistry.…”

Section: Antibacterial Mechanisms Of Cnmsmentioning

confidence: 99%

Antibacterial Carbon‐Based Nanomaterials

et al. 2018

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“…SVLs were also incubated with the same DES mixtures (Figure 4B,D), as disruption can be further identified by any additional losses relating to the solvent contained within the vesicles upon rupture. [ 21 ] For example, CAGE deposited only 790 ng cm −2 on an SVL compared to 1400 ng cm −2 on the SLB. Furthermore, there was a longer timeframe of equilibration.…”

Section: Resultsmentioning

confidence: 99%

Interactions of Choline and Geranate (CAGE) and Choline Octanoate (CAOT) Deep Eutectic Solvents with Lipid Bilayers

Neville,

Dobre,

Smith

et al. 2023

Adv Funct Materials

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Mixtures between choline and geranic acid (CAGE) have previously been shown to insert into lipid bilayers. This may be useful for the transdermal delivery of larger pharmaceuticals, however, little is known about the mechanism of activity. By comparing the interactions between CAGE and lipid bilayers with those of a less‐active, yet closely‐related analogue, choline octanoic acid (CAOT), a chemical basis can be investigated. Overall, six systems are studied here by neutron reflectivity, where d54‐1,2‐dimyristoyl‐sn‐glycero‐3‐phosphocholine (DMPC) solid‐supported phospholipid bilayers are first formed on SiO2 substrates before exposure to the deep eutectic solvent (DES). Components of the DES could be identified within the bilayer by exploiting contrast variation and selective deuteration. CAGE is shown to be a mild disruptive agent, free to insert and diffuse across the bilayer, preserving much of the bilayer integrity. Experiments identify co‐mingling of geranate ions inhibits the efficient packing of lipid tails, increasing hydration across the bilayer. Conversely, CAOT is found to both exchange and remove lipid molecules to achieve incorporation, inducing swelling and the formation of solvent patches. It appears these behaviors derive from the structures of the anions and thus amphiphilicity of the DES, laying the foundations for the rational design and optimization of these candidates toward transdermal delivery.

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“…[ 51 ] During the contact between the material and the bacteria, the nano‐edge of the 2D sheet can penetrate through the cell membrane of the bacteria like a blade. [ 52 ] At the same time, due to molecular dynamics, these inserted laminae can mechanically cut bacteria, resulting in the loss of intracellular substances and ultimately leading to bacterial death. This causes irreparable damage to the bacteria.…”

Section: Physicochemical Antibacterial Strategies and Mechanismsmentioning

confidence: 99%

Nanomaterials‐Enabled Physicochemical Antibacterial Therapeutics: Toward the Antibiotic‐Free Disinfections

Xing,

Guo,

et al. 2023

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Bacterial infection continues to be an increasing global health problem with the most widely accepted treatment paradigms restricted to antibiotics. However, the overuse and misuse of antibiotics have triggered multidrug resistance of bacteria, frustrating therapeutic outcomes, and leading to higher mortality rates. Even worse, the tendency of bacteria to form biofilms on living and nonliving surfaces further increases the difficulty in confronting bacteria because the extracellular matrix can act as a robust barrier to prevent the penetration of antibiotics and resist environmental damage. As a result, the inability to eliminate bacteria and biofilms often leads to persistent infection, implant failure, and device damage. Therefore, it is of paramount importance to develop alternative antimicrobial agents while avoiding the generation of bacterial resistance to prevent the large‐scale growth of bacterial resistance. In recent years, nano‐antibacterial materials have played a vital role in the antibacterial field because of their excellent physical and chemical properties. This review focuses on new physicochemical antibacterial strategies and versatile antibacterial nanomaterials, especially the mechanism and types of 2D antibacterial nanomaterials. In addition, this advanced review provides guidance on the development direction of antibiotic‐free disinfections in the antibacterial field in the future.

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Quantification of C₆₀-induced membrane disruption using a quartz crystal microbalance

Abstract: Fullerene C60 NPs adhere on lipid membrane due to electrostatic force and cause membrane disruption.

Cited by 13 publications

References 69 publications

Antibacterial Carbon‐Based Nanomaterials

Antibacterial Carbon‐Based Nanomaterials

Interactions of Choline and Geranate (CAGE) and Choline Octanoate (CAOT) Deep Eutectic Solvents with Lipid Bilayers

Nanomaterials‐Enabled Physicochemical Antibacterial Therapeutics: Toward the Antibiotic‐Free Disinfections

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Quantification of C60-induced membrane disruption using a quartz crystal microbalance

Abstract: Fullerene C60 NPs adhere on lipid membrane due to electrostatic force and cause membrane disruption.

Cited by 13 publications

References 69 publications

Antibacterial Carbon‐Based Nanomaterials

Antibacterial Carbon‐Based Nanomaterials

Interactions of Choline and Geranate (CAGE) and Choline Octanoate (CAOT) Deep Eutectic Solvents with Lipid Bilayers

Nanomaterials‐Enabled Physicochemical Antibacterial Therapeutics: Toward the Antibiotic‐Free Disinfections

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Quantification of C₆₀-induced membrane disruption using a quartz crystal microbalance