Quantification of cerebral vascular perfusion density via optical coherence tomography based on locally adaptive regional growth

Ma, Zhenhe; Ding, Ning; Yu, Yao; Ma, Yushu; Yuan, Xincheng; Wang, Yi; Zhao, Yuqian; Luan, Jingmin; Liu, Jian

doi:10.1364/ao.57.010117

Cited by 14 publications

(11 citation statements)

References 20 publications

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“…Uneven lighting is an additional problem that has to be faced in blood vessel segmentation. We employ the previously proposed "locally adaptive region growing" algorithm to segment blood vessels [39]. This is an improved algorithm based on the traditional region growing The advantage of this method is that it can better adapt to the drastic changes of local blood vessel signal intensity.…”

Section: Blood Vessels Segmentationmentioning

confidence: 99%

Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography

Meng

Tian

et al. 2022

Photonics

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Cerebral edema is a serious complication of ischemic cerebrovascular disease and mannitol is a commonly used dehydrating agent for relieving cerebral edema. However, the edema state and surrounding vascular perfusion level during mannitol treatment remains unclear, which affects the clinical application of the medicine. In this paper, we demonstrated the role of swept-source optical coherence tomography (OCT) in the evaluation of mannitol efficacy using mouse models. The OCT-based angiography and attenuation imaging technology were used to obtain the cerebral vascular perfusion level and cerebral edema state at different times. Vascular parameters and edema parameters were quantified and compared. Experimental results show that mannitol can significantly reduce the water content in the central region of edema, effectively inhibiting the rapid growth of the edema area, and restoring cerebral blood flow. On average, the edema area decreased by 33% after 2 h, and the vascular perfusion density increased by 12% after 5 h. This work helps to provide a valuable theoretical basis and research ideas for the clinical treatment of cerebral edema.

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Section: Blood Vessels Segmentationmentioning

confidence: 99%

Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography

Meng

Tian

et al. 2022

Photonics

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“…15 Optical coherence tomography (OCT) is a noninvasive method that allows volumetric imaging of biological tissues at high resolution and high speeds. 16,17 Another OCT-based technique, calculating optical attenuation coefficient (OAC) from OCT signals, has been attracting the attention of scholars. 18 Infrared light decays exponentially when penetrating tissues and its attenuation coefficient can be used to distinguish between different types of tissues, or different physiological states of the same tissue, and can be utilized to detect brain edema.…”

Section: Introductionmentioning

confidence: 99%

Cerebral edema detection in vivo after middle cerebral artery occlusion using swept-source optical coherence tomography

Liu

et al. 2019

Neurophoton.

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edema detection in vivo after middle cerebral artery occlusion using swept-source optical coherence tomography,"Abstract. Cerebral edema is a severe complication of ischemic cerebrovascular disease, which can lead to microcirculation compression resulting in additional ischemic damage. Real-time and continuous in vivo imaging techniques for edema detection are of great significance to basic research on cerebral edema. We attempted to monitor the cerebral edema status in rats with middle cerebral artery occlusion (MCAO) over time, using a wide field-of-view swept-source optical coherence tomography (SS-OCT) system. Optical attenuation coefficients (OACs) were calculated by an optimized depth-resolved estimation method, and en face OAC maps covering the whole cortex were obtained. Then, the tissue affected by edema was segmented from the OAC maps, and the cortical area affected by edema was estimated. Both magnetic resonance image (MRI) and brain water content measurements were used to verify the presence of cerebral edema. The results showed that the average OAC of the ischemic area gradually decreased as cerebral edema progressed, and the edema area detected by SS-OCT had high similarity in position and shape to that obtained by MRI. This work extends the application of OCT and provides an option for detecting cerebral edema in vivo after ischemic stroke. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…In this study, a spectral‐domain OCT (SD‐OCT) system with a central wavelength of 1310 nm and a spectral bandwidth of 60 nm was used to visualize the femoral vein and for all acquisitions as previously described . Briefly, the spectrometer used A line scan infrared InGaAs array detector operating at a 92 kHz line rate, and for each cross‐sectional image 400 A lines were collected.…”

Section: Methodsmentioning

confidence: 99%

In vivo monitoring of thrombosis in mice by optical coherence tomography

Liu

et al. 2019

Journal of Biophotonics

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The objective of this study is to establish a novel method for continuously monitoring thrombus progression with various outcome measures and to assess the efficacy of antithrombotic drugs in murine thrombosis model in mice. In the study, thrombus was induced in the femoral vein of mice by FeCl 3 and monitored over time by spectraldomain optical coherence tomography (OCT). Three-dimensional images of thrombi with or without heparin as an antithrombotic agent were obtained from OCT angiography. In addition, several parameters of thrombi were analyzed and compared between control and anticoagulant groups. By using OCT, we were able to trace thrombus generation in the same mouse in real time. We found that in our model heparin reduced thrombus size by~60% and thrombus cross-sectional area by 50%. OCT results also show that both time to thrombus size (>0.02mm 3 ) and time to occlusion (>30%) were significantly reduced after heparin addition. This study demonstrates that OCT reliably monitors thrombus generation and progression from various aspects including thrombus size. This enables us to measure the kinetic of thrombosis more accurately, and effectively evaluate the efficacy and activities of antithrombotic drugs.This model may represent a useful tool in antithrombotic drug discoveries in preclinical studies. K E Y W O R D Santithrombotic drugs, mice, optical coherence tomography, thrombosis

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Quantification of cerebral vascular perfusion density via optical coherence tomography based on locally adaptive regional growth

Cited by 14 publications

References 20 publications

Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography

Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography

Cerebral edema detection in vivo after middle cerebral artery occlusion using swept-source optical coherence tomography

In vivo monitoring of thrombosis in mice by optical coherence tomography

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