Quantification of crystallinity during indomethacin crystalline transformation from α- to γ-polymorphic forms and of the thermodynamic contribution to dissolution in aqueous buffer and solutions of solubilizer

Abstract

The thermodynamic properties and dissolution of indomethacin (INM) were analyzed as models for poorly water-soluble drugs.

How Does the Powder Mixture of Ibuprofen and Caffeine Attenuate the Solubility of Ibuprofen? Comparative Study for the Xanthine Derivatives to Recognize Their Intermolecular Interactions Using Fourier-Transform Infrared (FTIR) Spectra, Differential Scanning Calorimetry (DSC), and X-ray Powder Diffractometry (XRPD)

“…An exothermal signal was observed between the peaks at 445 and 459 K, indicating that the stable HD2 form of DCF melted and promptly transformed into a high-T m polymorph (or cocrystal with TPH). 56 The top of the IBP and DCF peaks decreased by 2−5 K depending on the mole fraction of TBR or XAT in the mixtures; however, the left intersections of these peaks remained constant (Figures 4e−h, and S1). Mixing DCF and TBR resulted in a T m value that marginally differed from that of pure.…”

“…Given that spectrometric data often exhibit co-occurrence (dependence) in individual signals due to intertwined absorptions (or emissions) from structural components, the SVD method efficiently accounts for this co-occurrence between similarity patterns. 59 SVD has been successfully applied to derivative spectra of various spectroscopic techniques, such as FTIR derivative spectra, 58 UV−visible spectra, 59,60 far-UV circular dichroism (CD) spectra, 61 powder X-ray diffractograms, [54][55][56]62 electron spin resonance (ESR), 63 fluorescence spectra, 64,65 and curves, 56 to quantify specific contributions of experimental conditions.…”