Quantification of cutaneous pharmacological reactions: comparison of laser Doppler scanning, colorimetry, planimetry and skin temperature measurement

Stücker, Markus; Reuther, T.; Hoffmann, Klaus; Aicher, Bernhard; Altmeyer, Peter

doi:10.1111/j.1600-0846.1996.tb00048.x

Cited by 12 publications

(15 citation statements)

References 21 publications

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“…Our results for the skin tissue are in line with findings of previous studies where skin blood flow was examined via laserDoppler-scanning [14]. Stücker et al [31] described the effects on cutaneous blood circulation in detail for nonivamide, nicoboxil and the combination of both compounds.…”

Section: Discussionsupporting

confidence: 91%

“…However, tissue temperature can be influenced by several physiological parameters even at constant room temperature and is therefore not reliable for the estimation of skin blood flow [6]. Evidence was found for the effects of the nonivamide / nicoboxil cream on skin blood flow in 1996 via laser-Doppler-scanning in collaboration with colorimetry and skin temperature measurement [14]. Early radioactive tracer experiments indicated the increase of muscular blood flow through application of the nonivamide / nicoboxil combination [7,8,10,15].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of haemoglobin changes of skin and muscle tissue of the calf induced by topical application of a nonivamide / nicoboxil cream

et al. 2011

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Topical agents inducing hyperaemisation like nonivamide or nicoboxil increase cutaneous blood flow and temperature and induce erythema. It is not proven up to now whether there is also a hyperaemisation effect in skeletal muscle. This study has the objective to determine the effects of a nonivamide / nicoboxil cream on haemodynamics in skin and calf muscle via optical spectroscopy in the visible and near-infrared with a separation of changes for skin and muscle. Left and right calves of 14 healthy subjects were treated with a nonivamide / nicoboxil cream or mock administration, and cutaneous and muscle haemoglobin were measured using a combined NIRS / VIS sensor. The topical application of the cream increased the concentration of oxygenated haemoglobin and tissue oxygen saturation significantly in skin as well as in muscle of the treated legs already after 15 minutes, with stronger and faster effects in skin. In contrast, the change in deoxygenated haemoglobin was found to be small. The kinetic of all changes varied widely between the subjects. The found haemoglobin changes might explain the beneficial effect of hyperaemisation creams for the treatment of minor injuries.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Evaluation of haemoglobin changes of skin and muscle tissue of the calf induced by topical application of a nonivamide / nicoboxil cream

et al. 2011

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“…Skin temperature has been used in many studies as an indicator for subcutaneous blood flow, but this parameter does not provide reliable evidence for the estimation of skin blood flow (Plötze 1951;Hensel et al 1954;Symons 1955;Rosseau and Desrosiers 1958;Stücker et al 1996). In 1996, using laser-Doppler-scanning together with colorimetry and skin temperature measurement, evidence was found that the combination nonivamide-nicoboxil (N/N) cream affects skin blood flow .…”

Section: Introductionmentioning

confidence: 97%

Evaluation of changes in the haemoglobin of skin and muscle tissue of the calf, as induced by topical application of a nonivamide/nicoboxil cream

Warnecke

Wendt

Winkler

et al. 2014

Can. J. Physiol. Pharmacol.

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Topical agents like nonivamide and nicoboxil induce hyperaemisation and increase cutaneous blood flow and temperature. This study aimed to determine the effects of a nonivamide-nicoboxil cream on haemodynamics in the skin and calf muscle, via optical spectroscopy, discriminating between the changes for skin and muscle. Optical spectroscopy was applied in the visible (VIS) and near-infrared (NIR) wavelength range. The study determined the effect of the cream on changes in oxygenated (ΔoxyHb) and deoxygenated (ΔdeoxyHb) haemoglobin in skin and muscle, as well as on tissue oxygen saturation (SO2) in the skin of 14 healthy subjects. The left and right calves of the subjects were either treated with nonivamide-nicoboxil cream or were sham-administered. NIR spectroscopy allows noninvasive in-vivo examination of the oxygenation of human skeletal muscle. Topical administration of the nonivamide-nicoboxil cream significantly increased the concentration of oxygenated haemoglobin and tissue oxygen saturation in the skin, as well as the concentration of oxygenated haemoglobin in the muscle of the treated legs after 15 min, but with stronger and faster effects in the skin. The topical application of the nonivamide-nicoboxil cream increased blood flow in (smaller vessels of) the skin and muscle tissues.

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“…HR-LDI is useful for a variety of dermatological investigations, e.g. objective assessment of patch test results (14)(15)(16), pharmacological reactions (17,18) and some skin diseases (18). With the HR-LDI unit used in this study (12,13) a defined skin area can be scanned, making it possible to evaluate either individual erythematous spots or an entire field with multiple areas of erythema and intervening normal skin.…”

mentioning

confidence: 99%

Comparison of three techniques for evaluating skin erythemal response for determination of sun protection factors of sunscreens: high resolution laser Doppler imaging, colorimetry and visual scoring

Wilhelm

Kaspar²,

Funkel³

2001

Photoderm Photoimm Photomed

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Quantification of cutaneous pharmacological reactions: comparison of laser Doppler scanning, colorimetry, planimetry and skin temperature measurement

Abstract: In summary, in our test system, laser Doppler scanning, colorimetry and planimetry had the same ability to quantify cutaneous pharmacological reactions. Laser Doppler scanning, however, has the advantage that it can be used without any contact whatsoever with the skin.

Cited by 12 publications

References 21 publications

Evaluation of haemoglobin changes of skin and muscle tissue of the calf induced by topical application of a nonivamide / nicoboxil cream

Evaluation of haemoglobin changes of skin and muscle tissue of the calf induced by topical application of a nonivamide / nicoboxil cream

Evaluation of changes in the haemoglobin of skin and muscle tissue of the calf, as induced by topical application of a nonivamide/nicoboxil cream

Comparison of three techniques for evaluating skin erythemal response for determination of sun protection factors of sunscreens: high resolution laser Doppler imaging, colorimetry and visual scoring

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