Quantification of dermal and transdermal delivery of meloxicam gels in rabbits

Patel, Mayurkumar; Joshi, Abhay; Hassanzadeth, Hana; Juluru, Ravi; Stagni, Grazia

doi:10.3109/03639045.2010.534098

Cited by 18 publications

(9 citation statements)

References 15 publications

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“…It was used to enhance the transdermal permeation of both lipophilic and amphiphilic compounds while found ineffective with hydrophilic compounds [72]. One study compared transdermal drug delivery through rabbit skin using 5% menthol as a PE, emphasizing the impact of the addition of PE to formulations to enhance systemic drug delivery [73].…”

Section: Permeation Enhancers (Accelerants)mentioning

confidence: 99%

Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs

et al. 2019

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Nanoemulsions (NEs) are colloidal dispersions of two immiscible liquids, oil and water, in which one is dispersed in the other with the aid of a surfactant/co-surfactant mixture, either forming oil-in-water (o/w) or water-in-oil (w/o) nanodroplets systems, with droplets 20–200 nm in size. NEs are easy to prepare and upscale, and they show high variability in their components. They have proven to be very viable, non-invasive, and cost-effective nanocarriers for the enhanced transdermal delivery of a wide range of active compounds that tend to metabolize heavily or suffer from undesirable side effects when taken orally. In addition, the anti-microbial and anti-viral properties of NE components, leading to preservative-free formulations, make NE a very attractive approach for transdermal drug delivery. This review focuses on how NEs mechanistically deliver both lipophilic and hydrophilic drugs through skin layers to reach the blood stream, exerting the desired therapeutic effect. It highlights the mechanisms and strategies executed to effectively deliver drugs, both with o/w and w/o NE types, through the transdermal way. However, the mechanisms reported in the literature are highly diverse, to the extent that a definite mechanism is not conclusive.

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Section: Permeation Enhancers (Accelerants)mentioning

confidence: 99%

Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs

et al. 2019

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“…Many publications have already provided substantial evidence that terpenes are capable of enhancing percutaneous absorption [11,12,13,14,15,16].…”

Section: Skin Penetration Enhancement Effectmentioning

confidence: 99%

Natural Terpenes as Penetration Enhancers for Transdermal Drug Delivery

et al. 2016

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Abstract:The greatest hindrance for transdermal drug delivery (TDD) is the barrier property of skin, especially the stratum corneum (SC). Various methodologies have been investigated and developed to enhance the penetration of drugs through the skin. Among them, the most popular approach is the application of penetration enhancers (PEs), including natural terpenes, a very safe and effective class of PEs. In the present paper, we focused on terpenes as skin PEs for TDD. The mechanism of their action, the factors affecting their penetration enhancement effect, as well as their possible skin toxicity were discussed. Terpenes abundant in nature have great potential in the development of PEs. Compared to synthetic PEs, natural terpenes have been proved to possess higher enhancement activity. Interaction with SC intercellular lipids is the main mechanism of action for terpenes. The key factor affecting the enhancement effect is the lipophilicity of both terpenes and drug molecules. In addition, a lot of terpenes have also been proved to be much less toxic compared to azone, the classic synthetic PE. In summary, terpenes may be preferred over the chemically synthesized compounds as safe and effective PEs to promote the percutaneous absorption of drugs.

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“…75 Transdermal delivery of 0.3% meloxicam in various delivery vehicles has recently been reported in rabbits, suggesting that this route of administration can deliver therapeutically relevant amounts of meloxicam in vivo. 76 Tramadol Tramadol hydrochloride is an analgesic agent that has become very popular despite relatively minimal evidence as to its appropriate dosing and efficacy in small mammals. Tramadol is active at opiate, α-adrenergic, and serotonergic receptors.…”

Section: Meloxicammentioning

confidence: 99%